INT144415

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Context Info
Confidence 0.27
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.42
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Egfr) cell morphogenesis (Egfr) intracellular (Egfr)
enzyme binding (Egfr) cytoplasm (Egfr) signal transducer activity (Egfr)
Egfr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 4 99.68 Very High Very High Very High
metalloproteinase 5 99.52 Very High Very High Very High
ischemia 3 94.36 High High
Opioid 1 93.20 High High
Enkephalin 1 91.32 High High
agonist 2 90.12 High High
opioid receptor 2 89.80 High High
MU agonist 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 1 96.32 Very High Very High Very High
Cv Unclassified Under Development 3 94.36 High High
Infarction 1 92.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cardioprotection of bradykinin at reperfusion involves transactivation of the epidermal growth factor receptor via matrix metalloproteinase-8.
Regulation (involves) of Positive_regulation (transactivation) of epidermal growth factor receptor associated with metalloproteinase and bradykinin
1) Confidence 0.27 Published 2009 Journal Acta Physiol (Oxf) Section Title Doc Link 19583703 Disease Relevance 0.10 Pain Relevance 0.46
In rabbit, this protection leads to phosphorylation of the pro-survival kinases Akt and extracellular signal-regulated kinase (ERK) and is dependent on transactivation of the epidermal growth factor receptor (EGFR).
Regulation (dependent) of Positive_regulation (transactivation) of EGFR
2) Confidence 0.26 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17545478 Disease Relevance 0.32 Pain Relevance 0.40

General Comments

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