INT144415

Context Info Confidence 0.27 First Reported 2007 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.42 Pain Relevance 0.86

endosome (Egfr) cell morphogenesis (Egfr) intracellular (Egfr) enzyme binding (Egfr) cytoplasm (Egfr) signal transducer activity (Egfr)

Egfr (Rattus norvegicus)

Pain Link Frequency Relevance Heat bradykinin 4 99.68 metalloproteinase 5 99.52 ischemia 3 94.36 Opioid 1 93.20 Enkephalin 1 91.32 agonist 2 90.12 opioid receptor 2 89.80 MU agonist 1 25.00

Disease Link Frequency Relevance Heat Myocardial Infarction 1 96.32 Cv Unclassified Under Development 3 94.36 Infarction 1 92.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Cardioprotection of bradykinin at reperfusion involves transactivation of the epidermal growth factor receptor via matrix metalloproteinase-8.

Regulation (involves) of Positive_regulation (transactivation) of epidermal growth factor receptor associated with metalloproteinase and bradykinin

1) Confidence 0.27 Published 2009 Journal Acta Physiol (Oxf) Section Title Doc Link 19583703 Disease Relevance 0.10 Pain Relevance 0.46

In rabbit, this protection leads to phosphorylation of the pro-survival kinases Akt and extracellular signal-regulated kinase (ERK) and is dependent on transactivation of the epidermal growth factor receptor (EGFR).

Regulation (dependent) of Positive_regulation (transactivation) of EGFR

2) Confidence 0.26 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17545478 Disease Relevance 0.32 Pain Relevance 0.40

General Comments

This test has worked.