INT14442

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Context Info
Confidence 0.31
First Reported 1981
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 19
Total Number 20
Disease Relevance 9.09
Pain Relevance 5.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GBE1) generation of precursor metabolites and energy (GBE1) small molecule metabolic process (GBE1)
transferase activity, transferring glycosyl groups (GBE1) carbohydrate metabolic process (GBE1)
Anatomy Link Frequency
neutrophils 3
neuronal 2
plasma 2
macrophages 1
blood 1
GBE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 18 99.84 Very High Very High Very High
Enkephalin 9 99.58 Very High Very High Very High
Cholecystokinin 17 99.40 Very High Very High Very High
cytokine 4 98.72 Very High Very High Very High
Inflammation 105 98.30 Very High Very High Very High
imagery 19 97.72 Very High Very High Very High
Angina 28 97.56 Very High Very High Very High
Bile 3 97.56 Very High Very High Very High
substance P 3 94.00 High High
ischemia 41 81.80 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 213 99.84 Very High Very High Very High
Pancreatitis 18 99.84 Very High Very High Very High
Acute Coronary Syndrome 46 99.40 Very High Very High Very High
Coronary Artery Disease 43 98.82 Very High Very High Very High
Cicatrix 45 98.54 Very High Very High Very High
INFLAMMATION 110 98.30 Very High Very High Very High
Angina 25 97.56 Very High Very High Very High
Hyponatremia 2 96.40 Very High Very High Very High
Infarction 35 96.30 Very High Very High Very High
Stress 23 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hydrolysis of enkephalins by human converting enzyme and localization of the enzyme in neuronal components of the brain.
Localization (localization) of enzyme in neuronal associated with enkephalin
1) Confidence 0.31 Published 1982 Journal Adv. Biochem. Psychopharmacol. Section Title Doc Link 6289625 Disease Relevance 0 Pain Relevance 0.46
Hydrolysis of enkephalins by human converting enzyme and localization of the enzyme in neuronal components of the brain.
Localization (localization) of enzyme in neuronal associated with enkephalin
2) Confidence 0.31 Published 1982 Journal Adv. Biochem. Psychopharmacol. Section Title Doc Link 6289625 Disease Relevance 0 Pain Relevance 0.46
The temporal characteristics of enzyme changes described are (i) the time lag from onset of chest pain until increasing enzyme concentrations occur, (ii) the time of maximum concentrations, and (iii) the period during which enzyme is released into blood.
Localization (released) of enzyme in blood associated with angina
3) Confidence 0.28 Published 1981 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 7256192 Disease Relevance 0.35 Pain Relevance 0.10
Functional capacity of pancreatic enzyme secretion remained elevated for 3 months after treatment.
Localization (secretion) of enzyme
4) Confidence 0.06 Published 1981 Journal Digestion Section Abstract Doc Link 6260564 Disease Relevance 0.16 Pain Relevance 0.20
D-Penicillamine did not affect enzyme release with either stimulus and interfered in the superoxide assay.
Localization (release) of enzyme
5) Confidence 0.02 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 3038127 Disease Relevance 0.14 Pain Relevance 0.15
Quinacrine inhibited superoxide production equally well with both stimuli but inhibited enzyme release only with fMet-Leu-Phe.
Localization (release) of enzyme
6) Confidence 0.02 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 3038127 Disease Relevance 0.18 Pain Relevance 0.16
In the postprandial state, peaks of enzyme secretion occurred at a frequency of about 1 peak/150 min.
Localization (secretion) of enzyme
7) Confidence 0.02 Published 1997 Journal Pancreas Section Abstract Doc Link 9260205 Disease Relevance 0.70 Pain Relevance 0.72
BACKGROUND/AIMS: The existence of a negative-feedback mechanism between pancreatic enzyme secretion and intraduodenal proteases and the role of cholecystokinin in its mediation in humans is debatable.
Localization (secretion) of enzyme associated with cholecystokinin
8) Confidence 0.02 Published 2000 Journal Hepatogastroenterology Section Abstract Doc Link 10919050 Disease Relevance 0.31 Pain Relevance 0.55
To further define intracellular enzyme release, creatine kinase levels were measured.
Localization (release) of enzyme
9) Confidence 0.02 Published 2004 Journal Plast. Reconstr. Surg. Section Abstract Doc Link 15318060 Disease Relevance 0.48 Pain Relevance 0.07
Myeloperoxidase: A New Biomarker of Inflammation in Ischemic Heart Disease and Acute Coronary Syndromes

Myeloperoxidase (MPO) is an enzyme stored in azurophilic granules of polymorphonuclear neutrophils and macrophages and released into extracellular fluid in the setting of inflammatory process.

Localization (released) of enzyme in macrophages associated with acute coronary syndrome, coronary artery disease, inflammation and urological neuroanatomy
10) Confidence 0.01 Published 2008 Journal Mediators of Inflammation Section Title Doc Link PMC2276594 Disease Relevance 0.85 Pain Relevance 0.15
a well-known enzyme, mainly released by activated neutrophils, characterised by
Localization (released) of enzyme in neutrophils
11) Confidence 0.01 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276594 Disease Relevance 1.09 Pain Relevance 0.11
The study does not support the hypothesis of a trypsin-mediated negative feedback control of human pancreatic enzyme secretion.
Localization (secretion) of enzyme
12) Confidence 0.01 Published 1988 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 3227303 Disease Relevance 0.17 Pain Relevance 0.28
The severely reduced enzyme secretion in chronic pancreatitis did not influence the basal or oleic acid-stimulated concentrations of the hormones in plasma.
Localization (secretion) of enzyme in plasma associated with chronic pancreatitis
13) Confidence 0.01 Published 1988 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 3227303 Disease Relevance 0.18 Pain Relevance 0.30
The concentrations of secretin and CCK in plasma and the pancreatic enzyme and volume secretions were unaffected by the addition of trypsin, but the initial bile acid output and the bicarbonate secretion in the period after gallbladder emptying were reduced during perfusion with trypsin.
Localization (secretions) of enzyme in plasma associated with bile and cholecystokinin
14) Confidence 0.01 Published 1988 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 3227303 Disease Relevance 0.18 Pain Relevance 0.29
The enzyme, released from human platelets by thrombin, was purified to homogeneity by ammonium sulfate precipitation, followed by chromatography on an octyl-Sepharose column and chromatofocusing on PBE 94.
Localization (released) of enzyme in platelets
15) Confidence 0.01 Published 1990 Journal J. Biol. Chem. Section Abstract Doc Link 1694176 Disease Relevance 0 Pain Relevance 0.10
Our results are in accord with prior observations that scar size is smaller in Non-Q STEMI, ejection fraction is higher and cardiac enzyme release is less than in Q-STEMI [7,8].
Localization (release) of enzyme associated with cicatrix
16) Confidence 0.01 Published 2008 Journal J Cardiovasc Magn Reson Section Body Doc Link PMC2584062 Disease Relevance 0.98 Pain Relevance 0.15
The aims of the current analyses were to 1) determine whether enzyme-determined infarct size would correlate to the degree of infarction measured by single-photon emission computed tomography (SPECT) imaging and to left ventricular ejection fraction (LVEF) measured by LV angiography, and 2) assess whether the amount of enzyme released could be used to predict clinical outcomes in patients treated with thrombolysis.
Spec (whether) Localization (released) of enzyme associated with infarction and imagery
17) Confidence 0.01 Published 2005 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC1236947 Disease Relevance 0.37 Pain Relevance 0.05
There were also no statistical differences between the trials with respect to CK and CK-MB data (Table 1); therefore, the trials were combined for further analysis of enzyme release.
Localization (release) of enzyme
18) Confidence 0.01 Published 2005 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC1236947 Disease Relevance 0.40 Pain Relevance 0.04
PDE4 inhibitors have a variety of anti-inflammatory effects on neutrophils, including inhibition of chemotaxis [73], suppression of proteolytic enzyme release, inhibition of proinflammatory cytokine release, particularly IL-8 and leukotriene B4 [74,75], and inhibition of CD11b integrin expression [73].
Localization (release) of enzyme in neutrophils associated with inflammation and cytokine
19) Confidence 0.01 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2873624 Disease Relevance 1.69 Pain Relevance 0.55
Myeloperoxidase: A New Biomarker of Inflammation in Ischemic Heart Disease and Acute Coronary Syndromes

Myeloperoxidase (MPO) is an enzyme stored in azurophilic granules of polymorphonuclear neutrophils and macrophages and released into extracellular fluid in the setting of inflammatory process.

Localization (released) of enzyme in polymorphonuclear neutrophils associated with acute coronary syndrome, coronary artery disease, inflammation and urological neuroanatomy
20) Confidence 0.00 Published 2008 Journal Mediators of Inflammation Section Title Doc Link PMC2276594 Disease Relevance 0.85 Pain Relevance 0.15

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