INT144427

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 7.89
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ccnd1) intracellular (Ccnd1) enzyme binding (Ccnd1)
cell cycle (Ccnd1) cell division (Ccnd1) kinase activity (Ccnd1)
Anatomy Link Frequency
parathyroid 2
MDA-MB-468 1
acinar cell 1
epithelial cells 1
Ccnd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 26 97.60 Very High Very High Very High
agonist 31 93.36 High High
antagonist 8 88.92 High High
Inflammation 55 88.64 High High
ischemia 1 77.92 Quite High
chemokine 3 75.04 Quite High
Inflammatory response 8 75.00 Quite High
cytokine 23 73.92 Quite High
Chronic pancreatitis 1 68.72 Quite High
cINOD 28 68.40 Quite High
Disease Link Frequency Relevance Heat
Cancer 354 98.80 Very High Very High Very High
Parathyroid Cancer 80 98.60 Very High Very High Very High
Malignant Neoplastic Disease 23 97.64 Very High Very High Very High
Repression 9 96.32 Very High Very High Very High
Apoptosis 97 94.48 High High
Targeted Disruption 37 94.12 High High
Death 16 91.20 High High
Breast Cancer 101 91.12 High High
Ovarian Cancer 1 90.40 High High
Adenoma 9 89.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, cyclin D1 mRNA and protein levels were significantly increased in lungs from CCSPrtTA/tetO-Sox17 mice just prior to the onset of proliferation, consistent with the concept that cyclin D1 contributes to the cell cycle reentry of mature respiratory epithelial cells following expression of Sox17.
Transcription (levels) of cyclin D1 in epithelial cells
1) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
However, Stat3 promotes proliferation primarily by stimulating transcription of cyclinB1, cdc2, c-myc and cyclinD1 [55,65,66], along with the induction of the immediate early genes c-jun and c-fos [67] and repression of the cell cycle inhibitor p21 [68].
Transcription (transcription) of cyclinD1 associated with repression
2) Confidence 0.29 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.25 Pain Relevance 0.04
A change in the expression of CD1 mRNA has been found during the progression from benign to malignant parathyroid tumor cells CD1 oncoprotein is overexpressed frequently in parathyroid carcinoma [5-7].
Transcription (expression) of CD1 in parathyroid associated with malignant neoplastic disease and parathyroid cancer
3) Confidence 0.25 Published 2008 Journal Diagn Pathol Section Body Doc Link PMC2627811 Disease Relevance 1.56 Pain Relevance 0.03
Parathyroid carcinoma cells showed a variable staining with the probe used: Cells strongly positive from CD1 mRNA varied with only weakly stained tumor cells.
Transcription (positive) of CD1 in Parathyroid associated with cancer and parathyroid cancer
4) Confidence 0.24 Published 2008 Journal Diagn Pathol Section Body Doc Link PMC2627811 Disease Relevance 0.92 Pain Relevance 0
of CDK4 in G1, by depletion of cyclin D1 mRNA resulting in a
Transcription (resulting) of cyclin D1
5) Confidence 0.22 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559918 Disease Relevance 1.17 Pain Relevance 0.12
At later timepoints, some mice showed focal areas of acinar cell damage with upregulated mRNA levels for Cyclin D1 and p16(INK4a).
Transcription (levels) of Cyclin D1 in acinar cell
6) Confidence 0.20 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17546589 Disease Relevance 0.55 Pain Relevance 0.25
-catenin degradation and thus, activating the transcription of Wnt target genes such as engrailed and cyclin-D1.
Transcription (transcription) of cyclin-D1
7) Confidence 0.20 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.23 Pain Relevance 0.34
Preliminary data evaluating cyclin D1 levels in MDA-MB-468 cells after celecoxib treatment were inconclusive (data not shown) and more thorough analysis is needed.
Transcription (levels) of cyclin D1 in MDA-MB-468
8) Confidence 0.11 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1175053 Disease Relevance 0.84 Pain Relevance 0.07
Caveolin-1 contains a caveolin scaffolding domain that inhibits activation extracellular signal-regulated kinase-1/2, represses cyclin D1 transcription, and induces CIP-dependent G0/G1 arrest [11].
Transcription (transcription) of cyclin D1
9) Confidence 0.11 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.74 Pain Relevance 0.08
-catenin, as well as the transcription of Wnt target genes en-1 and cyclin-D1 [115].
Transcription (transcription) of cyclin-D1
10) Confidence 0.07 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.63 Pain Relevance 0.12

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