INT144432

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.36
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ccnd1) intracellular (Ccnd1) enzyme binding (Ccnd1)
cell cycle (Ccnd1) cell division (Ccnd1) kinase activity (Ccnd1)
Anatomy Link Frequency
acinar cell 2
epithelial cells 2
parathyroid 2
Ccnd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 13 97.60 Very High Very High Very High
Inflammation 7 88.64 High High
chemokine 1 75.04 Quite High
Inflammatory response 1 75.00 Quite High
cytokine 1 73.92 Quite High
Chronic pancreatitis 1 69.40 Quite High
fibrosis 1 65.64 Quite High
Pain 2 29.64 Quite Low
agonist 9 5.00 Very Low Very Low Very Low
depression 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 9 97.64 Very High Very High Very High
Parathyroid Cancer 40 97.24 Very High Very High Very High
Targeted Disruption 14 94.80 High High
Drug Induced Neurotoxicity 12 89.36 High High
Cancer 27 88.92 High High
INFLAMMATION 8 88.64 High High
Carcinoma 10 83.28 Quite High
Disease 63 71.44 Quite High
Apoptosis 14 69.44 Quite High
Pancreatitis 1 69.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, cyclin D1 mRNA and protein levels were significantly increased in lungs from CCSPrtTA/tetO-Sox17 mice just prior to the onset of proliferation, consistent with the concept that cyclin D1 contributes to the cell cycle reentry of mature respiratory epithelial cells following expression of Sox17.
Positive_regulation (increased) of Transcription (levels) of cyclin D1 in epithelial cells
1) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
A change in the expression of CD1 mRNA has been found during the progression from benign to malignant parathyroid tumor cells CD1 oncoprotein is overexpressed frequently in parathyroid carcinoma [5-7].
Positive_regulation (change) of Transcription (expression) of CD1 in parathyroid associated with malignant neoplastic disease and parathyroid cancer
2) Confidence 0.16 Published 2008 Journal Diagn Pathol Section Body Doc Link PMC2627811 Disease Relevance 1.57 Pain Relevance 0.03
-catenin degradation and thus, activating the transcription of Wnt target genes such as engrailed and cyclin-D1.
Positive_regulation (activating) of Transcription (transcription) of cyclin-D1
3) Confidence 0.14 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.23 Pain Relevance 0.34
At later timepoints, some mice showed focal areas of acinar cell damage with upregulated mRNA levels for Cyclin D1 and p16(INK4a).
Positive_regulation (upregulated) of Transcription (levels) of Cyclin D1 in acinar cell
4) Confidence 0.14 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17546589 Disease Relevance 0.55 Pain Relevance 0.26

General Comments

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