INT144434

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Context Info
Confidence 0.16
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.60
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Erbb2) plasma membrane (Erbb2) nucleus (Erbb2)
kinase activity (Erbb2) cytoplasm (Erbb2)
Anatomy Link Frequency
acinar cells 2
Erbb2 (Mus musculus)
ras (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 3 97.84 Very High Very High Very High
cytokine 1 97.40 Very High Very High Very High
chemokine 1 96.88 Very High Very High Very High
Inflammatory response 1 75.00 Quite High
Chronic pancreatitis 1 51.96 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 3 97.84 Very High Very High Very High
Targeted Disruption 3 93.80 High High
Pancreatitis 1 51.96 Quite High
Pancreatic Cancer 1 50.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that overexpression of ErbB2 in acinar cells leads to increased RAS activity without cell cycle progression and mediates inflammation via NF-kappaB.
Gene_expression (overexpression) of ErbB2 in acinar cells Positive_regulation (increased) of RAS associated with inflammation
1) Confidence 0.16 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17546589 Disease Relevance 0.60 Pain Relevance 0.28

General Comments

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