INT144461

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.03
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SSTR2) cell-cell signaling (SSTR2) cytoplasm (SSTR2)
signal transducer activity (SSTR2)
SSTR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 107 100.00 Very High Very High Very High
opioid receptor 11 100.00 Very High Very High Very High
Cannabinoid receptor 1 100.00 Very High Very High Very High
mu opioid receptor 1 90.84 High High
agonist 5 87.68 High High
Opioid 1 79.60 Quite High
imagery 6 5.00 Very Low Very Low Very Low
Dopamine 5 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 87 98.96 Very High Very High Very High
Adenocarcinoma 3 96.68 Very High Very High Very High
Apoptosis 9 89.68 High High
Chondrosarcoma 1 88.16 High High
Diarrhoea 10 50.32 Quite High
Neuroendocrine Cancer 11 50.00 Quite Low
Disease 22 43.44 Quite Low
Somatostatinoma 4 41.92 Quite Low
Achlorhydria 1 28.20 Quite Low
Gallstones 1 26.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The loss of SSTR 2 may consequently promote tumour growth and make it clear the therapeutic inefficacy of SST analogues in such kind of neoplasia.
Negative_regulation (loss) of SSTR 2 associated with cancer and somatostatin
1) Confidence 0.49 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 1.03 Pain Relevance 0.24
In addition, we demonstrated the interaction of M6a with a number of other G protein-coupled receptors (GPCRs) such as the delta-opioid receptor, cannabinoid receptor CB1, and somatostatin receptor sst2A, suggesting that M6a might play a general role in the regulation of certain GPCRs.
Negative_regulation (number) of somatostatin receptor sst2A associated with cannabinoid receptor, somatostatin and opioid receptor
2) Confidence 0.04 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17548356 Disease Relevance 0 Pain Relevance 0.73

General Comments

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