INT14447

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Context Info
Confidence 0.79
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 12.77
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F2) extracellular space (F2) extracellular region (F2)
plasma membrane (F2)
Anatomy Link Frequency
platelets 7
macrophages 1
blood 1
endothelial cells 1
lymphocytes 1
F2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 90 100.00 Very High Very High Very High
bradykinin 4 100.00 Very High Very High Very High
Neuropeptide 1 100.00 Very High Very High Very High
Serotonin 1 100.00 Very High Very High Very High
Inflammatory response 9 98.24 Very High Very High Very High
agonist 5 95.04 Very High Very High Very High
imagery 17 94.28 High High
substance P 6 93.68 High High
cva 132 90.08 High High
cytokine 38 87.80 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 100 100.00 Very High Very High Very High
Stroke 71 99.84 Very High Very High Very High
Thrombocytopenia 8 99.72 Very High Very High Very High
Neurogenic Inflammation 1 99.68 Very High Very High Very High
Diabetes Mellitus 82 99.40 Very High Very High Very High
Thrombophilia 188 99.38 Very High Very High Very High
Vasculitis 12 99.36 Very High Very High Very High
Abruptio Placentae 44 99.28 Very High Very High Very High
Thrombosis 111 99.20 Very High Very High Very High
Myocardial Infarction 74 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immune-mediated platelet activation results in thrombocytopenia, endothelial thrombin release and development of thrombosis, mainly venous.
Localization (release) of thrombin in platelet associated with thrombocytopenia and thrombosis
1) Confidence 0.79 Published 2005 Journal Hellenic journal of cardiology : HJC = Hell?nik? kardiologik? epithe?r?s? Section Abstract Doc Link 15981562 Disease Relevance 0.70 Pain Relevance 0.15
Approximately half the children presenting with AIS have a predisposing cause14 (symptomatic AIS) (fig 3), while the remainder were previously well (cryptogenic AIS); around 80% of both groups have abnormal arterial imaging.14 Intermediate risk factors include infections, hypertension, anaemia (including iron deficiency),14 25 hyperhomocysteinaemia26 and dyslipidaemias including elevated lipoprotein(a).27 Thrombophilias such as protein C deficiency, anticardiolipin antibodies and the factor V Leiden and prothrombin 20210 mutations are more frequent in ischaemic stroke populations than in controls27 but may be more commonly associated with VST rather than AIS,14 16 17 although some appear to be independent risk factors for recurrent cryptogenic AIS.22 23
Localization (frequent) of prothrombin associated with intracranial sinus thrombosis, anaemia, stroke, thrombophilia, hypertension, imagery and infection
2) Confidence 0.73 Published 2008 Journal Archives of Disease in Childhood Section Body Doc Link PMC2677268 Disease Relevance 1.84 Pain Relevance 0.08
In summary, our findings demonstrate that acute hyperglycemia in acute myocardial infarction patients without a previous history of diabetes is associated with increased thrombin generation and platelet activation at the site of vascular injury as well as greater resistance to fibrinolysis.
Localization (generation) of thrombin in platelet associated with hyperglycemia, diabetes mellitus, vasculitis and myocardial infarction
3) Confidence 0.61 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494657 Disease Relevance 1.00 Pain Relevance 0
The current study shows that elevated glucose levels are associated with significantly augmented thrombin formation and platelet protein secretion in response to vascular injury not only in patients with type 2 diabetes but also in those with no prior history of diabetes and hyperglycemia during acute myocardial infarction.
Localization (secretion) of thrombin in platelet associated with hyperglycemia, diabetes mellitus, vasculitis and myocardial infarction
4) Confidence 0.57 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494657 Disease Relevance 1.21 Pain Relevance 0.04
The authors review the available evidence linking these factors to the development of inflammatory lesions of the cerebral vasculature, emphasizing: 1) neurogenic inflammation due to massive release of sensory nerve neuropeptides; 2) hemoglobin from lysed erythrocytes, which creates functional lesions of endothelial and smooth muscle cells; 3) activity, expression and metabolites of lipoxygenases cyclooxygenases and nitric oxide synthases; 4) the possible role of endothelin-1 as a pro-inflammatory agent; 5) serotonin, histamine and bradykinin which are especially involved in blood-brain barrier disruption; 6) the prothrombotic and pro-inflammatory action of complement and thrombin towards endothelium; 7) the multiple actions of activated platelets, including platelet-derived growth factor production; 8) the presence of perivascular and intramural macrophages and granulocytes and their interaction with adhesion molecules; 9) the evolution, origins, and effects of pro-inflammatory cytokines, especially IL-1, TNF-alpha and IL-6.
Localization (release) of thrombin in platelets associated with inflammation, neuropeptide, neurogenic inflammation, bradykinin, serotonin, adhesions and cytokine
5) Confidence 0.38 Published 2002 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 11949877 Disease Relevance 1.28 Pain Relevance 0.76
In another study [63], the rate of the prothrombin mutation in 27 women with abruptio placentae was 18.5% compared to 3.2% in controls (OR 5.8; 95% CI 1.8–18.6), P = 0.01.
Localization (rate) of prothrombin mutation associated with abruptio placentae
6) Confidence 0.35 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305329 Disease Relevance 1.51 Pain Relevance 0
RESULTS: The immediate increase in prostacyclin release from thrombin or tryptase stimulated human bladder microvascular endothelial cells depended on the activation of membrane associated calcium independent phospholipase A2, resulting in an increase in arachidonic acid production.
Localization (release) of thrombin in bladder
7) Confidence 0.29 Published 2006 Journal J. Urol. Section Body Doc Link 16952710 Disease Relevance 0 Pain Relevance 0
Collectively, these results reveal the distinct distribution of FXa, prothrombin, and thrombin on thrombi formed under shear, and confirm the important role of exposed PS for fibrin formation under flow.


Localization (distribution) of prothrombin
8) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2861630 Disease Relevance 0.25 Pain Relevance 0
A dose-dependent prolongation of PT, activated partial thromboplastin time (aPTT), and HepTest to a similar extent to inhibition of FXa were seen, and it was suggested that the inhibition of the FXa activity of rivaroxaban can be monitored by these clotting tests or by measurement of FXa alone (Kubitza 2005a).
Localization (prolongation) of PT associated with coagulation disorder
9) Confidence 0.17 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597756 Disease Relevance 0.44 Pain Relevance 0.06
The inflammatory process promotes the release of serine protease by neutrophils, macrophages, lymphocytes, and endothelial cells.
Localization (release) of serine protease in endothelial cells associated with inflammation
10) Confidence 0.16 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872884 Disease Relevance 0.60 Pain Relevance 0.29
The therapeutic effects on systemic blood pressure and organ failure, however, could not be explained on the basis of its direct effect on thrombin.
Localization (effect) of thrombin in blood
11) Confidence 0.14 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.38 Pain Relevance 0.12
The commonest inherited thrombophilias are factor V Leiden (FVL) and prothrombin gene mutation (PGM).
Localization (mutation) of prothrombin gene associated with thrombophilia
12) Confidence 0.12 Published 2010 Journal PLoS Medicine Section Abstract Doc Link PMC2885985 Disease Relevance 1.37 Pain Relevance 0
Ambrisentan did not affect the Cmax or AUC of warfarin, although a small reduction in prothrombin time was observed (?
Localization (time) of prothrombin
13) Confidence 0.09 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.13 Pain Relevance 0.03
(no. 19) PI3K Reg Class 1A/p85 alpha, in addition to mediating megakaryocytic expansion, enhances thrombin-dependent alpha granule secretion in platelets [54].
Localization (secretion) of thrombin in platelets
14) Confidence 0.09 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958630 Disease Relevance 0 Pain Relevance 0.11
Activation with shear force, collagen, and low amount of calcium and thrombin (Group D) showed a significant increase in the release of VEGF (mean concentration 1264 pg/ml) as compared to the other methods using high calcium and thrombin (mean concentration 273 - 548 pg/ml), but the release of other growth factors were lowered (Fig. 1A).
Localization (release) of thrombin
15) Confidence 0.06 Published 2010 Journal The Journal of Advanced Prosthodontics Section Body Doc Link PMC2984511 Disease Relevance 0.07 Pain Relevance 0.05
The inflammatory process promotes the release of serine protease by neutrophils, macrophages, lymphocytes, and endothelial cells.
Localization (release) of serine protease in lymphocytes associated with inflammation
16) Confidence 0.06 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872884 Disease Relevance 0.60 Pain Relevance 0.29
The inflammatory process promotes the release of serine protease by neutrophils, macrophages, lymphocytes, and endothelial cells.
Localization (release) of serine protease in neutrophils associated with inflammation
17) Confidence 0.06 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872884 Disease Relevance 0.60 Pain Relevance 0.29
The inflammatory process promotes the release of serine protease by neutrophils, macrophages, lymphocytes, and endothelial cells.
Localization (release) of serine protease in macrophages associated with inflammation
18) Confidence 0.06 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872884 Disease Relevance 0.60 Pain Relevance 0.29
The enzyme, released from human platelets by thrombin, was purified to homogeneity by ammonium sulfate precipitation, followed by chromatography on an octyl-Sepharose column and chromatofocusing on PBE 94.
Localization (released) of thrombin in platelets
19) Confidence 0.04 Published 1990 Journal J. Biol. Chem. Section Abstract Doc Link 1694176 Disease Relevance 0 Pain Relevance 0.13
The ability of physiological stimuli (e.g. thrombin or collagen) to release the deamidase from platelets indicates that it may also be involved in the local metabolism of bioactive peptides.
Localization (release) of thrombin in platelets
20) Confidence 0.04 Published 1990 Journal J. Biol. Chem. Section Abstract Doc Link 1694176 Disease Relevance 0.10 Pain Relevance 0

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