INT14448

Context Info Confidence 0.67 First Reported 1990 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 34 Total Number 34 Disease Relevance 17.35 Pain Relevance 2.85

extracellular region (COL5A2) molecular_function (COL5A2)

Anatomy Link Frequency cartilage 3 cleavage 3 joint 3 extracellular matrix 3 capsule 1 COL5A2 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 275 99.98 Osteoarthritis 457 99.36 Inflammation 187 99.18 aspirin 83 98.88 Arthritis 167 98.60 Potency 20 97.76 fibrosis 23 94.92 rheumatoid arthritis 203 93.24 cytokine 107 90.44 chemokine 9 76.40

Disease Link Frequency Relevance Heat Cancer 295 99.86 Osteoarthritis 91 99.36 Uterine Fibroids 361 99.32 Severe Combined Immunodeficiency 2 99.32 INFLAMMATION 191 99.18 Apoptosis 93 98.76 Arthritis 238 98.60 Arthropathy 27 98.44 Necrosis 29 98.20 Keloid Scars 103 98.02

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Fibrilar types I, II and III collagen maintain tissue architecture and rigidity16, while type V and XI proteins regulate the diameter of collagen fibrils.17–21

Localization (diameter) of collagen

1) Confidence 0.67 Published 2008 Journal Clinics Section Body Doc Link PMC2664193 Disease Relevance 0.50 Pain Relevance 0.04

The stromal cells secrete an extracellular matrix composed mainly of collagen fibrils arranged in orthogonal lamellae, and proteoglycans [8].

Localization (secrete) of collagen in extracellular matrix

2) Confidence 0.65 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533033 Disease Relevance 0.09 Pain Relevance 0

The inflammatory process is negligible in diseased tendons, where type I collagen is found in minor proportion, diffusely distributed, and grossly surrounded by type III fibrils.

Localization (found) of collagen in tendons associated with inflammation

3) Confidence 0.58 Published 2008 Journal Clinics Section Body Doc Link PMC2664193 Disease Relevance 0.36 Pain Relevance 0.05

In conclusion, the data here presented indicate a marked decrease in proteoglycan synthesis and changes in corneal collagen organization 24 h after in vitro LASIK surgery in human cornea.

Localization (organization) of collagen in cornea

4) Confidence 0.57 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533033 Disease Relevance 0.15 Pain Relevance 0

The original area of the collagen gels was the area (2 cm2) of a well of a 24 well plate, before release from the sides of the wells.

Localization (release) of collagen

5) Confidence 0.28 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0 Pain Relevance 0

The process of collagen cleavage and denaturation of the triple helical molecule exposes certain protein sequences, termed neoepitopes, within the collagen molecule.

Localization (cleavage) of collagen in cleavage

6) Confidence 0.24 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716783 Disease Relevance 0.08 Pain Relevance 0.04

The type II collagen biomarkers indicative of degradation fall into three groups according to the localization of the particular epitope within the collagen molecule: cleavage neoepitopes localized to the collagenase cleavage site; denaturation neoepitopes localized to the triple-helical domain and made accessible to the detection reagents by unwinding of the triple helix; and epitopes localized to the mature ends or telopeptides of the molecule (Table 2).

Localization (localized) of collagen in cleavage

7) Confidence 0.22 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716783 Disease Relevance 0.09 Pain Relevance 0.05

Together with AH9, the sandwich ELISA assay has been used to monitor the release of amino- and carboxy-terminal fragments of type II collagen from cartilage explants treated with IL-1alpha (Croucher and Hollander, 1999).

Localization (release) of collagen in cartilage

8) Confidence 0.22 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716783 Disease Relevance 0.17 Pain Relevance 0.03

The type II collagen biomarkers indicative of degradation fall into three groups according to the localization of the particular epitope within the collagen molecule: cleavage neoepitopes localized to the collagenase cleavage site; denaturation neoepitopes localized to the triple-helical domain and made accessible to the detection reagents by unwinding of the triple helix; and epitopes localized to the mature ends or telopeptides of the molecule (Table 2).

Localization (localized) of collagen in cleavage

9) Confidence 0.20 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716783 Disease Relevance 0.10 Pain Relevance 0.05

The present protocol was established with primary human hip joint capsule MFs by varying cell numbers, collagen gel volumes and concentrations, time points of detachment, and different concentrations of TGF-?

Localization (concentrations) of collagen in capsule

10) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875629 Disease Relevance 0.09 Pain Relevance 0.11

Based on the present case and on those previously reported in the literature, STMF is characterized by: 1) exclusive incidence in the male sex; 2) variable immunoreactivity of the neoplastic cells for desmin, probably reflecting an origin from a peculiar subset of myofibroblasts, or, alternatively, a further myoid differentiation; 3) variable abundance of (hyalinized) collagen; 4) presence of amianthoid fibers.

Localization (abundance) of collagen

11) Confidence 0.12 Published 1997 Journal Tumori Section Abstract Doc Link 9428923 Disease Relevance 0.64 Pain Relevance 0.07

Osteochondral explants were fixed and decalcified for 4 weeks and subsequently embedded in paraffin, while collagen gel samples were fixed overnight in a phosphate-buffered solution of 4% Para formaldehyde and embedded in paraffin. 5 ?

Localization (samples) of collagen

12) Confidence 0.10 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2921357 Disease Relevance 0.05 Pain Relevance 0.03

This means that these enzymes dissolve basement membranes, an organization of collagen and extracellular matrices, enabling cancer cells to infiltrate and destroy adjacent normal tissues.

Localization (organization) of collagen in basement membranes associated with cancer

13) Confidence 0.10 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693571 Disease Relevance 1.62 Pain Relevance 0

That is, cancer cells releases collagenase and dissove collagen between cells/tissues.

Localization (releases) of collagen associated with cancer

14) Confidence 0.09 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693571 Disease Relevance 1.61 Pain Relevance 0

Depending on the individual gene expression level in each patient, gene expression variances in regulatory pathways may lead to enhanced inflammation [53,54], angiogenesis [71,72], enhanced collagen synthesis and secretion [9], and/or a reduced rate of apoptosis [73], thus potentially contributing to hyperplasia of the SM [74], collagen-dependent fibrosis of the joints [64], and a prolonged life span of activated synovial cells in RA [73,75].

Localization (secretion) of collagen in synovial cells associated with fibrosis, inflammation, rheumatoid arthritis, apoptosis and hyperplasia

15) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575612 Disease Relevance 1.77 Pain Relevance 0.49

With a decrease in soluble collagen secretion, we hypothesized that the expression of individual ECM components known to be disrupted in leiomyomas may also be regulated by ATRA.

Localization (secretion) of collagen associated with uterine fibroids

16) Confidence 0.06 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.81 Pain Relevance 0

Leiomyomas are characterized by excessive collagen production in the ECM.7,16 We therefore evaluated the effect of ATRA treatment on collagen production in leiomyoma cell cultures by measuring salt soluble collagen secreted into the media after 24 h of ATRA treatment, prior to one cycle of cell division.

Localization (secreted) of collagen associated with uterine fibroids

17) Confidence 0.06 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.87 Pain Relevance 0

As shown in Fig. 2, leiomyoma cells demonstrated a decrease in collagen secretion with increasing ATRA exposure.

Localization (secretion) of collagen associated with uterine fibroids

18) Confidence 0.06 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.84 Pain Relevance 0

In this study, we report that bortezomib used alone and in combination with a glucocorticoid as front-line treatment in previously untreated, bisphosphonate-naïve patients stimulates bone formation not only as shown by an increase in bALP but also through the use of a novel bone marker, pro-collagen type I N-terminal propeptide (PINP) that is released as collagen is deposited and becomes insoluble during the formation of the organic bone matrix (34) and may, therefore, be a better marker for ongoing bone formation.

Localization (released) of collagen

19) Confidence 0.06 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0.34 Pain Relevance 0

The epinephrine-collagen cartridge (EPI-COLL) is sensitive to aspirin and can be used for the detection of aspirin resistance [6].

Localization (cartridge) of collagen in EPI associated with aspirin

20) Confidence 0.06 Published 2005 Journal Thromb J Section Body Doc Link PMC1192820 Disease Relevance 0.06 Pain Relevance 0.21

General Comments

This test has worked.