INT144483

Context Info Confidence 0.68 First Reported 2007 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 2.48 Pain Relevance 0.49

nucleus (Tfdp1) cell cycle (Tfdp1) DNA binding (Tfdp1) transcription factor binding (Tfdp1)

Anatomy Link Frequency plaques 2 neurons 1 Tfdp1 (Mus musculus)

Pain Link Frequency Relevance Heat Spinal cord 2 99.48 Inflammation 5 93.68 cINOD 2 71.92 allodynia 1 56.00 Hyperalgesia 1 55.44 cytokine 3 25.00

Disease Link Frequency Relevance Heat Alzheimer's Dementia 22 99.76 Amyloid Plaque 6 98.20 Nociception 1 95.72 INFLAMMATION 7 93.68 Neuropathic Pain 1 56.00 Hyperalgesia 1 55.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The localization of the PGD2 receptors DP1 and CRTH in spinal cord neurons, particularly in neurons of lamina I and II involved in the processing of nociceptive stimuli, supports a role of PGD2 under inflammatory conditions.

Localization (localization) of DP1 in neurons associated with nociception, inflammation and spinal cord

1) Confidence 0.68 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18028337 Disease Relevance 0.39 Pain Relevance 0.28

In the brain of Tg2576 mice, a model of AD, HPGDS and DP1 proteins were mainly localized immunocytochemically in microglia and astrocytes in the plaques, and the levels of their mRNAs increased in parallel with amyloid beta deposition.

Localization (localized) of DP1 in plaques associated with alzheimer's dementia

2) Confidence 0.39 Published 2007 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 17549007 Disease Relevance 1.04 Pain Relevance 0.11

In situ hybridization studies revealed that DP1 mRNA was specifically localized in microglia and reactive astrocytes within senile plaques of AD brains.

Localization (localized) of DP1 in plaques associated with alzheimer's dementia and amyloid plaque

3) Confidence 0.37 Published 2007 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 17549007 Disease Relevance 1.05 Pain Relevance 0.09

General Comments

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