INT144486

Context Info Confidence 0.38 First Reported 2007 Last Reported 2008 Negated 0 Speculated 0 Reported most in Title Documents 4 Total Number 4 Disease Relevance 3.15 Pain Relevance 0.13

nucleus (Tfdp1) cell cycle (Tfdp1) DNA binding (Tfdp1) transcription factor binding (Tfdp1)

Anatomy Link Frequency B cells 1 brains 1 astrocytes 1 microglia 1 Tfdp1 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 1 79.56 Inflammatory response 5 64.92 Inflammation 64 53.08 cINOD 3 48.00 cytokine 9 47.28 chemokine 2 5.00 aspirin 1 5.00 abdominal pain 1 5.00

Disease Link Frequency Relevance Heat Alzheimer's Dementia 33 99.84 Amyloid Plaque 9 98.56 Apoptosis 11 78.32 Targeted Disruption 16 77.48 INFLAMMATION 73 64.52 Infection 10 20.00 Superinfection 8 8.96 Peritonitis 14 5.00 Adhesions 6 5.00 Injury 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

While the mechanism of PGD2-dependent B-cell clearance is unknown, a Toll-like receptor (TLR)–mediated transient down-regulation of integrins and CD9 on B1 cells was shown to be required for detachment of these cells from the local peritoneal matrix and their subsequent efflux from the inflamed cavity.28 Whether BW245C alters CD9 expression needs further investigation, but given that B cells disappear concomitantly with PGD2 synthesis, it is possible that DP1 activation may play a role in regulating this pathway of B1 cell detachment and efflux.

Positive_regulation (activation) of DP1 in B cells

1) Confidence 0.38 Published 2008 Journal Blood Section Body Doc Link PMC2602590 Disease Relevance 0.29 Pain Relevance 0.07

Here, we report that the level of the mRNA of the receptor for PGD2 (DP1) was increased in AD brains compared with the level in non-AD brains.

Positive_regulation (increased) of DP1 in brains associated with alzheimer's dementia

2) Confidence 0.34 Published 2007 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 17549007 Disease Relevance 1.00 Pain Relevance 0

Hematopoietic prostaglandin D synthase and DP1 receptor are selectively upregulated in microglia and astrocytes within senile plaques from human patients and in a mouse model of Alzheimer disease.

Positive_regulation (upregulated) of DP1 in microglia associated with alzheimer's dementia and amyloid plaque

3) Confidence 0.34 Published 2007 Journal J. Neuropathol. Exp. Neurol. Section Title Doc Link 17549007 Disease Relevance 0.93 Pain Relevance 0.03

Hematopoietic prostaglandin D synthase and DP1 receptor are selectively upregulated in microglia and astrocytes within senile plaques from human patients and in a mouse model of Alzheimer disease.

Positive_regulation (upregulated) of DP1 in astrocytes associated with alzheimer's dementia and amyloid plaque

4) Confidence 0.12 Published 2007 Journal J. Neuropathol. Exp. Neurol. Section Title Doc Link 17549007 Disease Relevance 0.93 Pain Relevance 0.03

General Comments

This test has worked.