INT144490

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Context Info
Confidence 0.58
First Reported 2001
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 14.09
Pain Relevance 2.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Tnfsf11) extracellular space (Tnfsf11) extracellular region (Tnfsf11)
plasma membrane (Tnfsf11) intracellular (Tnfsf11) cytoplasm (Tnfsf11)
Anatomy Link Frequency
osteoblasts 5
stromal cells 3
osteoclast 2
T cells 2
Tnfsf11 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 209 99.96 Very High Very High Very High
Inflammation 217 99.68 Very High Very High Very High
withdrawal 1 99.32 Very High Very High Very High
cytokine 169 99.16 Very High Very High Very High
Arthritis 161 92.40 High High
imagery 2 92.12 High High
Inflammatory marker 2 90.96 High High
cva 4 88.56 High High
antagonist 17 82.28 Quite High
chemokine 23 57.72 Quite High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 56 99.98 Very High Very High Very High
Rheumatoid Arthritis 209 99.96 Very High Very High Very High
INFLAMMATION 225 99.68 Very High Very High Very High
Calcification 121 99.20 Very High Very High Very High
Postmenopausal Osteoporosis 4 98.12 Very High Very High Very High
Osteoporosis 121 97.64 Very High Very High Very High
Bone Cancer 38 97.48 Very High Very High Very High
Syndrome 14 96.60 Very High Very High Very High
Hypercalcemia 173 96.36 Very High Very High Very High
Arthritis 190 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, canonical Wnt signaling was recently shown to modulate RANKL and OPG expression in osteoblasts in vitro, resulting in inhibition of osteoclastogenesis [34].
Regulation (modulate) of Gene_expression (expression) of OPG in osteoblasts
1) Confidence 0.58 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924519 Disease Relevance 1.00 Pain Relevance 0.11
The findings of this investigation suggested that activation of the MEK/ERK and the PI3K/Akt pathways and inhibition of p38MAPK pathway were involved in RANKL expression induced by MIP-1alpha in bone-marrow stromal cells and osteoblasts.
Regulation (involved) of Gene_expression (expression) of RANKL in stromal cells
2) Confidence 0.45 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.48 Pain Relevance 0.04
Interestingly, canonical Wnt signaling was recently shown to modulate RANKL and OPG expression in osteoblasts in vitro, resulting in inhibition of osteoclastogenesis [34].
Regulation (modulate) of Gene_expression (expression) of RANKL in osteoblasts
3) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924519 Disease Relevance 1.00 Pain Relevance 0.11
Nevertheless, OPG and sRANKL serum levels have been
Regulation (been) of Gene_expression (levels) of OPG
4) Confidence 0.42 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2248226 Disease Relevance 1.75 Pain Relevance 0.09
On the other hand, its effects on the expression of OPG further support the postulated bone protective property of VIP.
Regulation (effects) of Gene_expression (expression) of OPG
5) Confidence 0.36 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.67 Pain Relevance 0.28
Nevertheless, OPG and sRANKL serum levels have been
Regulation (been) of Gene_expression (levels) of sRANKL
6) Confidence 0.36 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2248226 Disease Relevance 1.75 Pain Relevance 0.09
Importantly, expression of RANKL is regulated by pro-inflammatory cytokines such as TNF?
Regulation (regulated) of Gene_expression (expression) of RANKL associated with inflammation and cytokine
7) Confidence 0.28 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860063 Disease Relevance 0.89 Pain Relevance 0.45
For example, hormones, drugs or antibodies could be used (or have been applied) to regulate the expression of RANK-L and OPG, or binding of RANK-L to RANK (reviewed in [37] and discussed in [38]).
Regulation (regulate) of Gene_expression (expression) of OPG
8) Confidence 0.23 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 1.19 Pain Relevance 0.04
Mechanisms involved in this process operate by modulating the expression of RANK, RANKL and OPG.
Regulation (modulating) of Gene_expression (expression) of OPG
9) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.98 Pain Relevance 0.40
This positive effect of IL-6 on osteoclastogenesis and bone loss appears to be independent of RANKL expression and is probably a result of a direct stimulatory effect on osteoclast precursors [40,47].
Neg (independent) Spec (appears) Regulation (independent) of Gene_expression (expression) of RANKL in osteoclast
10) Confidence 0.16 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128900 Disease Relevance 0.68 Pain Relevance 0.26
The findings of this investigation suggested that activation of the MEK/ERK and the PI3K/Akt pathways and inhibition of p38MAPK pathway were involved in RANKL expression induced by MIP-1alpha in bone-marrow stromal cells and osteoblasts.
Regulation (involved) of in osteoblasts Gene_expression (expression) of RANKL in stromal cells
11) Confidence 0.15 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.48 Pain Relevance 0.04
From our HIV-infected cohort, elevated OPG levels, rather than CRP, IL-1?
Regulation (infected) of Gene_expression (levels) of OPG associated with acquired immune deficiency syndrome or hiv infection
12) Confidence 0.14 Published 2010 Journal J Int AIDS Soc Section Body Doc Link PMC2859852 Disease Relevance 1.85 Pain Relevance 0.11
Since the expression of RANKL/RANK can be controlled by sex hormones, it is possible to speculate that this system may control gender specific differences in immunity and could be involved in the higher incidence of autoimmune diseases and osteoporosis in women.
Regulation (controlled) of Gene_expression (expression) of RANKL associated with autoimmune disease and osteoporosis
13) Confidence 0.14 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1308846 Disease Relevance 0.67 Pain Relevance 0.09
RANKL is normally expressed in osteoblasts and stromal cells, but in pro-inflammatory environments, as in RA, RANKL expression is elevated and spreads, particularly to activated T cells [139,143,144].
Regulation (elevated) of Gene_expression (expression) of RANKL in T cells associated with inflammation and rheumatoid arthritis
14) Confidence 0.12 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 0.63 Pain Relevance 0.28
Serum levels of OPG and RANKL were not changed.
Neg (not) Regulation (changed) of Gene_expression (levels) of OPG
15) Confidence 0.00 Published 2007 Journal J. Rheumatol. Section Body Doc Link 17610317 Disease Relevance 0.05 Pain Relevance 0

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