INT144491

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.82
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Tnfsf11) extracellular space (Tnfsf11) extracellular region (Tnfsf11)
plasma membrane (Tnfsf11) intracellular (Tnfsf11) cytoplasm (Tnfsf11)
Anatomy Link Frequency
MC3T3-E1 4
Tnfsf11 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2 75.00 Quite High
Pain 2 39.32 Quite Low
Disease Link Frequency Relevance Heat
Osteoporosis 14 86.64 High High
INFLAMMATION 2 75.00 Quite High
Bone Fracture 2 40.00 Quite Low
Pain 2 39.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
U0126 (a MEK1/2 inhibitor) or LY294002 (a PI3K inhibitor) was added to ST2 and MC3T3-E1 cells, and was found to inhibit RANKL mRNA and RANKL protein expression in these cells.
Negative_regulation (inhibit) of Transcription (expression) of RANKL protein in MC3T3-E1
1) Confidence 0.42 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.41 Pain Relevance 0.04
U0126 (a MEK1/2 inhibitor) or LY294002 (a PI3K inhibitor) was added to ST2 and MC3T3-E1 cells, and was found to inhibit RANKL mRNA and RANKL protein expression in these cells.
Negative_regulation (inhibit) of Transcription (expression) of RANKL mRNA in MC3T3-E1
2) Confidence 0.42 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.41 Pain Relevance 0.04

General Comments

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