INT14450

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Context Info
Confidence 0.14
First Reported 1990
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.10
Pain Relevance 0.50

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small molecule metabolic process (NEU1) hydrolase activity, acting on glycosyl bonds (NEU1) cytoplasmic membrane-bounded vesicle (NEU1)
plasma membrane (NEU1) lysosome (NEU1)
NEU1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 116 88.52 High High
cytokine 75 87.12 High High
Enkephalin 1 52.48 Quite High
palliative 5 49.32 Quite Low
substance P 3 47.84 Quite Low
bradykinin 1 46.72 Quite Low
tolerance 10 5.00 Very Low Very Low Very Low
Potency 10 5.00 Very Low Very Low Very Low
ketamine 5 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunization 30 100.00 Very High Very High Very High
Acne 410 99.88 Very High Very High Very High
Infection 106 99.36 Very High Very High Very High
Disease 46 98.96 Very High Very High Very High
Bacterial Pneumonia 5 98.20 Very High Very High Very High
Death 35 97.80 Very High Very High Very High
Influenza Virus Infection 5 97.24 Very High Very High Very High
Disorders Of Galactose Metabolism 1 90.00 High High
Pressure And Volume Under Development 40 89.84 High High
INFLAMMATION 106 88.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of sialidase immunization on P. acnes growth was also explored.
sialidase Binding (immunization) of associated with immunization
1) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 0.61 Pain Relevance 0.06
This data suggests that mice immunized with sialidase produce antibody that can neutralize the cytotoxicity of P. acnes in vitro.
sialidase Binding (immunized) of
2) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 1.05 Pain Relevance 0.15
To assess the immunogenicity of sialidase, ICR mice were vaccinated with heat killed P. acnes for nine weeks.
sialidase Binding (immunogenicity) of
3) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 0.79 Pain Relevance 0
Immunogenicity in Mice Vaccinated with Recombinant Sialidase
Sialidase Binding (Immunogenicity) of
4) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 0.88 Pain Relevance 0
50843035) containing an LPXTG cell wall-anchoring motif in the C-terminal domain [6], [7] as a target for acne vaccine development.
sialidase Binding (target) of associated with acne
5) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 1.62 Pain Relevance 0.23
A more specific glycan analysis by sequential digestion with sialidase, fucosidase and mannosidases (Figure 3C) showed approximately 40% of the glycoforms were sialylated and 25% contained ?
sialidase Binding (digestion) of
6) Confidence 0.02 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.07 Pain Relevance 0
This protective protein complexes with beta-galactosidase and neuraminidase in lysosomes and is vitally important in maintaining their activity and stability.
neuraminidase Binding (complexes) of
7) Confidence 0.02 Published 1990 Journal J. Biol. Chem. Section Abstract Doc Link 1694176 Disease Relevance 0.09 Pain Relevance 0.05

General Comments

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