INT14450

Context Info Confidence 0.14 First Reported 1990 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 7 Total Number 7 Disease Relevance 5.10 Pain Relevance 0.50

small molecule metabolic process (NEU1) hydrolase activity, acting on glycosyl bonds (NEU1) cytoplasmic membrane-bounded vesicle (NEU1) plasma membrane (NEU1) lysosome (NEU1)

NEU1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 116 88.52 cytokine 75 87.12 Enkephalin 1 52.48 palliative 5 49.32 substance P 3 47.84 bradykinin 1 46.72 tolerance 10 5.00 Potency 10 5.00 ketamine 5 5.00 lidocaine 1 5.00

Disease Link Frequency Relevance Heat Immunization 30 100.00 Acne 410 99.88 Infection 106 99.36 Disease 46 98.96 Bacterial Pneumonia 5 98.20 Death 35 97.80 Influenza Virus Infection 5 97.24 Disorders Of Galactose Metabolism 1 90.00 Pressure And Volume Under Development 40 89.84 INFLAMMATION 106 88.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The effect of sialidase immunization on P. acnes growth was also explored.

sialidase Binding (immunization) of associated with immunization

1) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 0.61 Pain Relevance 0.06

This data suggests that mice immunized with sialidase produce antibody that can neutralize the cytotoxicity of P. acnes in vitro.

sialidase Binding (immunized) of

2) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 1.05 Pain Relevance 0.15

To assess the immunogenicity of sialidase, ICR mice were vaccinated with heat killed P. acnes for nine weeks.

sialidase Binding (immunogenicity) of

3) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 0.79 Pain Relevance 0

Immunogenicity in Mice Vaccinated with Recombinant Sialidase

Sialidase Binding (Immunogenicity) of

4) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 0.88 Pain Relevance 0

50843035) containing an LPXTG cell wall-anchoring motif in the C-terminal domain [6], [7] as a target for acne vaccine development.

sialidase Binding (target) of associated with acne

5) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 1.62 Pain Relevance 0.23

A more specific glycan analysis by sequential digestion with sialidase, fucosidase and mannosidases (Figure 3C) showed approximately 40% of the glycoforms were sialylated and 25% contained ?

sialidase Binding (digestion) of

6) Confidence 0.02 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.07 Pain Relevance 0

This protective protein complexes with beta-galactosidase and neuraminidase in lysosomes and is vitally important in maintaining their activity and stability.

neuraminidase Binding (complexes) of

7) Confidence 0.02 Published 1990 Journal J. Biol. Chem. Section Abstract Doc Link 1694176 Disease Relevance 0.09 Pain Relevance 0.05

General Comments

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