INT144500

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Context Info
Confidence 0.77
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 1.62
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (CCL3, Tnfsf11) cytoplasm (CCL3, Tnfsf11) extracellular space (CCL3, Tnfsf11)
extracellular region (CCL3, Tnfsf11) cell differentiation (Tnfsf11) cell-cell signaling (CCL3)
Anatomy Link Frequency
osteoclasts 4
stromal cells 3
osteoblasts 1
CCL3 (Homo sapiens)
Tnfsf11 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 4 79.84 Quite High
Inflammation 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Osteoporosis 28 91.32 High High
Bone Fracture 4 80.52 Quite High
Pain 4 79.84 Quite High
INFLAMMATION 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, our group investigated the mechanism by which RANKL expression is induced by MIP-1alpha and the effects of MIP-1alpha on the activation of osteoclasts.
MIP-1alpha Positive_regulation (induced) of Gene_expression (expression) of RANKL in osteoclasts
1) Confidence 0.77 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.33 Pain Relevance 0.12
The findings of this investigation suggested that activation of the MEK/ERK and the PI3K/Akt pathways and inhibition of p38MAPK pathway were involved in RANKL expression induced by MIP-1alpha in bone-marrow stromal cells and osteoblasts.
MIP-1alpha Positive_regulation (induced) of Gene_expression (expression) of RANKL in stromal cells
2) Confidence 0.55 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.48 Pain Relevance 0.04
In the present study, our group investigated the mechanism by which RANKL expression is induced by MIP-1alpha and the effects of MIP-1alpha on the activation of osteoclasts.
MIP-1alpha Positive_regulation (induced) of Gene_expression (expression) of RANKL in osteoclasts
3) Confidence 0.51 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.33 Pain Relevance 0.12
The findings of this investigation suggested that activation of the MEK/ERK and the PI3K/Akt pathways and inhibition of p38MAPK pathway were involved in RANKL expression induced by MIP-1alpha in bone-marrow stromal cells and osteoblasts.
MIP-1alpha Positive_regulation (induced) of in osteoblasts Gene_expression (expression) of RANKL in stromal cells
4) Confidence 0.19 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.48 Pain Relevance 0.04

General Comments

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