INT144522

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Context Info
Confidence 0.76
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 27
Total Number 31
Disease Relevance 3.31
Pain Relevance 3.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpc3)
Anatomy Link Frequency
heart 3
neurons 2
aorta 1
cerebrum 1
skeletal muscle 1
Trpc3 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 193 100.00 Very High Very High Very High
Hippocampus 45 100.00 Very High Very High Very High
member 8 6 99.32 Very High Very High Very High
TRP channel 1002 95.44 Very High Very High Very High
Calcium channel 10 91.56 High High
calcitonin gene related peptide 11 85.28 High High
Neuropeptide 6 84.00 Quite High
mu opioid receptor 4 83.68 Quite High
Spinal cord 6 74.64 Quite High
trigeminal ganglion 75 57.72 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 345 99.36 Very High Very High Very High
Ganglion Cysts 135 82.40 Quite High
Nociception 3 80.24 Quite High
Disease 40 79.04 Quite High
Coronary Heart Disease 53 70.24 Quite High
Targeted Disruption 98 66.24 Quite High
Cancer 2 63.76 Quite High
INFLAMMATION 28 50.00 Quite Low
Natriuresis 5 50.00 Quite Low
Repression 7 45.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of TRPC3 (canonical-type transient receptor potential cation channel type 3) is tightly regulated during skeletal muscle cell differentiation, and a functional interaction between TRPC3 and RyR1 [(ryanodine receptor type 1), an SR (sarcoplasmic reticulum) Ca2+-release channel] regulates the gain of SR Ca2+ release during EC (excitation-contraction) coupling.
Gene_expression (expression) of TRPC3 in skeletal muscle cell associated with member 8
1) Confidence 0.76 Published 2008 Journal Biochem. J. Section Abstract Doc Link 18215135 Disease Relevance 0 Pain Relevance 0.10
Trpc3 is overexpressed in vestibular organs of TrkbPLC/PLC mutants and may lead to the fiber misdirection
Gene_expression (overexpressed) of Trpc3
2) Confidence 0.73 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2964534 Disease Relevance 0 Pain Relevance 0
Here we show that TRPC3 is overexpressed in vestibular neurons of TrkBPLC point mutants.
Gene_expression (overexpressed) of TRPC3 in neurons
3) Confidence 0.73 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2964534 Disease Relevance 0 Pain Relevance 0.05
Overexpression of the Trpc3 channel has been reported to interfere with the cellular calcium homeostasis both in vitro and in vivo [32,33], this could explain the misdirection of fibers observed in the TrkbPLC/PLC mutants.
Gene_expression (Overexpression) of Trpc3
4) Confidence 0.73 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2964534 Disease Relevance 0 Pain Relevance 0.04
We found TRPV4 expression almost as high as that of the most abundant TRPC member, TRPC3.
Gene_expression (expression) of TRPC3
5) Confidence 0.69 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0.08 Pain Relevance 0.07
TRPC3 and TRPV4 expression was even exceeded by TRPM5 and TRPM7 (Fig. 3).
Gene_expression (expression) of TRPC3
6) Confidence 0.69 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0.08 Pain Relevance 0.06
In addition, TRPC3 expression was obviously present in many other tissues such as liver, lung, kidney, ovary and testis.
Gene_expression (expression) of TRPC3 in kidney
7) Confidence 0.69 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0
However, compared to the TRPC transcripts, TRPV2 and 4 mRNAs were expressed at much lower levels reaching only 3–10% of those of TRPC3 and TRPC4 (Fig. 2B and 3).
Gene_expression (expressed) of TRPC3
8) Confidence 0.60 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.03
The tested brain regions were consistently positive for TRPC3 and 6 as well as for TRPV2 and 4 mRNAs.
Gene_expression (positive) of TRPC3 in brain
9) Confidence 0.60 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.28
For TRPC3, C5 and TRPC6 positive reactions were observed in the cytoplasm of neuronal cells in the C2 area of the hippocampus without any strong variation of expression levels (Fig. 4A).
Gene_expression (expression) of TRPC3 in neuronal associated with hippocampus
10) Confidence 0.60 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.15
Muscle tissues, aorta (col 13), heart (col 15) uterus (col 10) and skeletal muscle (col 5) were positive for few TRP mRNAs, in particular TRPC3 and TRPV4, but the signals were relatively weak.
Gene_expression (positive) of TRPC3 in Muscle tissues
11) Confidence 0.60 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.26
Cellular localization of TRPC3, TRPC5 and TRPC6 mRNAs
Gene_expression (mRNAs) of TRPC3
12) Confidence 0.60 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.16
Since TRPC3/6, but not TRPC1, has been shown to be essential in the guidance of nerve growth cones by BDNF [11], we examined the expression of Trpc3 in the vestibular organ of TrkbPLC/PLC mutants and control (Trkb+/+ and the TrkbWT/WT) mice.
Gene_expression (expression) of Trpc3 in growth cones
13) Confidence 0.56 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2964534 Disease Relevance 0.08 Pain Relevance 0
As shown in Fig. 8C, Trpc3 was overexpressed in the TrkbPLC/PLC mutants compared to controls (one-way ANOVA, p = 0.02).
Gene_expression (overexpressed) of Trpc3
14) Confidence 0.56 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2964534 Disease Relevance 0.08 Pain Relevance 0
Epididymis revealed strong expression of TRPC3 in the epithelium of the Ductuli epididymis and Ductuli efferentes testes while the other cell types were negative.
Gene_expression (expression) of TRPC3
15) Confidence 0.53 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0.06 Pain Relevance 0.09
However, TRPC3, C6, TRPM7, M3, TRPV2 and V4 expression showed marked differences in the three tested mouse strains.
Gene_expression (expression) of TRPC3 associated with sprains and strains
16) Confidence 0.53 Published 2006 Journal BMC Genomics Section Abstract Doc Link PMC1557673 Disease Relevance 0.25 Pain Relevance 0.19
On this basis, TRPC3 expression was higher in some tissues, e.g. in cerebrum, skeletal muscle and heart of C57Bl/10 mice while TRPC6 expression was lower in the same tissues (Fig. 5).
Gene_expression (expression) of TRPC3 in heart
17) Confidence 0.53 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0.64 Pain Relevance 0.10
As TRPC3 and C6 are expressed at significant levels in mouse heart, these two channels have the potential to form several Ca2+ conducting non selective cation channels in myocytes and contribute to cardiac Ca2+ homeostasis.
Gene_expression (expressed) of TRPC3 in heart
18) Confidence 0.53 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0.13 Pain Relevance 0
TRPC3/C6 channels are involved in the calcium responses of adult myocytes to Ang II
Gene_expression (channels) of TRPC3 in myocytes
19) Confidence 0.52 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0 Pain Relevance 0
Tissue preparation, the in situ hybridization (ISH) procedure, and the probes for TRPM8, TRPV1, Mrgprc11, CGRP, Mrgprd, TRPC3, P2X3, Mrgpra3, Mrgprb4, TrkA, SCG10, DRASIC, Ret, and GluR5/Grik1, have been described previously [14,24,41].
Gene_expression (probes) of TRPC3
20) Confidence 0.51 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.06 Pain Relevance 0

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