INT144523

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.04
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.47
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gfra2)
Anatomy Link Frequency
sympathetic 2
epidermis 2
Gfra2 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 58 99.84 Very High Very High Very High
TRP channel 14 76.24 Quite High
nociceptor 44 49.00 Quite Low
Calcitonin gene-related peptide 44 39.76 Quite Low
Nav1.9 2 36.48 Quite Low
sodium channel 6 36.20 Quite Low
tetrodotoxin 6 32.20 Quite Low
Action potential 2 27.80 Quite Low
Dopamine 2 24.96 Low Low
noradrenaline 10 22.88 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 28 85.24 High High
Ganglion Cysts 132 77.60 Quite High
Apoptosis 16 5.00 Very Low Very Low Very Low
Death 14 5.00 Very Low Very Low Very Low
Sprains And Strains 12 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 12 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Hyperalgesia 2 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Data on the coexpression of GFRalpha receptors differ between studies (Bennett et al. 1998; Kashiba et al. 2003).Expression of GFRalpha1 and GFRalpha2, but not GFRalpha3, depends on NGF, as shown in newborn NGF/Bax double-mutant mice where GFRalpha1 is undetectable and GFRalpha2 expression is strongly reduced (Luo et al. 2007).
Regulation (depends) of Gene_expression (.Expression) of GFRalpha2 associated with nerve growth factor
1) Confidence 0.04 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.17
The expression of mRNAs for GFRalpha1, GFRalpha2, GFRalpha3 and ret is dynamically regulated in mouse sympathetic ganglia during embryogenesis (Nishino et al. 1999; Enomoto et al. 2001).
Regulation (regulated) of Gene_expression (expression) of GFRalpha2 in sympathetic
2) Confidence 0.03 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.47 Pain Relevance 0.04
GFR/Ret signaling, in turn, autoregulates expression of both GFRalpha1 and GFRalpha2 and promotes expression of TrpA1, MrgA1, MrgA3, and MrgB4, acquisition of normal neuronal size, axonal innervation of the epidermis, and postnatal extinction of the NGF receptor TrkA.
Regulation (autoregulates) of Gene_expression (expression) of GFRalpha2 in epidermis
3) Confidence 0.00 Published 2007 Journal Neuron Section Abstract Doc Link 17553423 Disease Relevance 0 Pain Relevance 0
Here, we show that expression of Ret and its coreceptors GFRalpha1 and GFRalpha2 is dependent on NGF.
Regulation (dependent) of Gene_expression (expression) of GFRalpha2
4) Confidence 0.00 Published 2007 Journal Neuron Section Abstract Doc Link 17553423 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox