INT144524

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Context Info
Confidence 0.64
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 1.05
Pain Relevance 2.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mrgpra3) plasma membrane (Mrgpra3) molecular_function (Mrgpra3)
cellular_component (Mrgpra3) biological_process (Mrgpra3) signal transducer activity (Mrgpra3)
Anatomy Link Frequency
neurons 3
spinal nerve 1
epidermis 1
Mrgpra3 (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 11 98.56 Very High Very High Very High
nociceptor 398 94.64 High High
Pain 105 94.28 High High
Inflammation 71 93.84 High High
Spinal cord 19 90.84 High High
superficial lamina 5 89.08 High High
medulla 1 87.96 High High
qutenza 5 80.88 Quite High
primary afferent fibers 1 80.16 Quite High
Neuropeptide 5 78.56 Quite High
Disease Link Frequency Relevance Heat
Pain 122 94.28 High High
INFLAMMATION 71 93.84 High High
Pruritus 5 89.64 High High
Nociception 4 73.00 Quite High
Cancer 5 63.76 Quite High
Inflammatory Pain 95 62.16 Quite High
Neuropathic Pain 240 55.56 Quite High
Ganglion Cysts 1 41.76 Quite Low
Hyperalgesia 35 34.16 Quite Low
Targeted Disruption 112 26.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, expression of several Mrgpr class GPCRs (Mrgpra3, Mrgprb4, and Mrgprc11), which was eliminated in E-CKO mice [14,24], was fully "restored" in L-CKO mice (Fig. 1C).
Gene_expression (expression) of Mrgpra3
1) Confidence 0.64 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0 Pain Relevance 0.36
The second one is observed in neurons expressing Mrgpra3, b4, and c11.
Gene_expression (expressing) of Mrgpra3 in neurons
2) Confidence 0.56 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0 Pain Relevance 0.60
Similarly, Runx1-transient neurons consist of IB4-;TrkA+ and IB4+; Mrgpra3/b4/c11+ neurons [23,24,31].
Gene_expression (neurons) of Mrgpra3 in neurons
3) Confidence 0.56 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.11 Pain Relevance 0.98
Tissue preparation, the in situ hybridization (ISH) procedure, and the probes for TRPM8, TRPV1, Mrgprc11, CGRP, Mrgprd, TRPC3, P2X3, Mrgpra3, Mrgprb4, TrkA, SCG10, DRASIC, Ret, and GluR5/Grik1, have been described previously [14,24,41].
Gene_expression (probes) of Mrgpra3
4) Confidence 0.56 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.06 Pain Relevance 0
Another program B gene Mrgprc11 is expressed in both Mrgpra3+ and Mrgprb4+ neurons [24].
Gene_expression (expressed) of Mrgpra3 in neurons
5) Confidence 0.49 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.20 Pain Relevance 0.14
Expression of rat MrgC and MrgA is down regulated in DRG following spinal nerve ligation provided additional evidence that these receptors are somehow functionally linked to pain [4].
Gene_expression (Expression) of MrgA in spinal nerve associated with pain and eae
6) Confidence 0.23 Published 2008 Journal Mol Pain Section Body Doc Link PMC2242784 Disease Relevance 0.67 Pain Relevance 0.72
GFR/Ret signaling, in turn, autoregulates expression of both GFRalpha1 and GFRalpha2 and promotes expression of TrpA1, MrgA1, MrgA3, and MrgB4, acquisition of normal neuronal size, axonal innervation of the epidermis, and postnatal extinction of the NGF receptor TrkA.
Gene_expression (expression) of MrgA3 in epidermis
7) Confidence 0.08 Published 2007 Journal Neuron Section Abstract Doc Link 17553423 Disease Relevance 0 Pain Relevance 0

General Comments

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