INT14453

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Context Info
Confidence 0.80
First Reported 1981
Last Reported 2009
Negated 2
Speculated 4
Reported most in Abstract
Documents 44
Total Number 48
Disease Relevance 2.46
Pain Relevance 14.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mme) plasma membrane (Mme)
Anatomy Link Frequency
brain 9
brainstem 3
striatum 2
globus pallidus 2
spinal cord 2
Mme (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 98 100.00 Very High Very High Very High
Neuropeptide 43 100.00 Very High Very High Very High
Endogenous opioid 2 100.00 Very High Very High Very High
medulla 49 99.96 Very High Very High Very High
Spinal cord 25 99.82 Very High Very High Very High
agonist 26 99.76 Very High Very High Very High
narcan 6 99.54 Very High Very High Very High
qutenza 19 99.48 Very High Very High Very High
amygdala 6 99.48 Very High Very High Very High
c fibre 8 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cough 93 95.64 Very High Very High Very High
Stress 7 94.64 High High
Pancreatitis 4 91.56 High High
Pain 9 91.32 High High
Injury 5 88.92 High High
INFLAMMATION 9 88.68 High High
Pressure Volume 2 Under Development 4 88.60 High High
Urological Neuroanatomy 10 82.08 Quite High
Diarrhoea 1 70.92 Quite High
Anxiety Disorder 3 70.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fluorescent histochemical localization of neutral endopeptidase-24.11 (enkephalinase) in the rat brainstem.
Localization (localization) of enkephalinase in brainstem associated with medulla and enkephalin
1) Confidence 0.80 Published 1990 Journal J. Comp. Neurol. Section Title Doc Link 1694188 Disease Relevance 0 Pain Relevance 0.39
The preliminary analysis of sections clearly showed a discrete localization of enkephalinase in enkephalin enriched regions, such as caudate nucleus, putamen, globus pallidus, and substantia nigra.
Localization (localization) of enkephalinase in putamen associated with substantia nigra and enkephalin
2) Confidence 0.80 Published 1984 Journal C. R. Acad. Sci. III, Sci. Vie Section Abstract Doc Link 6440665 Disease Relevance 0 Pain Relevance 0.19
Fluorescent histochemical localization of neutral endopeptidase-24.11 (enkephalinase) in the rat spinal cord.
Localization (localization) of enkephalinase in spinal cord associated with spinal cord
3) Confidence 0.80 Published 1989 Journal J. Comp. Neurol. Section Title Doc Link 2918102 Disease Relevance 0 Pain Relevance 0.21
The cellular localization of the rat brain neutral endopeptidase (NEP, EC 3.4.24.11) was investigated by quantitative autoradiography of the enzyme inhibitor [3H]N-[(2RS)-3-hydroxyaminocarbonyl-2-benzyl-1-oxopropyl]glycine ([3H]HACBO-Gly) after lesions of the striatum, nigrostriatal and corticostriatal pathways.
Spec (investigated) Localization (localization) of NEP in striatum
4) Confidence 0.78 Published 1987 Journal Brain Res. Section Abstract Doc Link 2829989 Disease Relevance 0 Pain Relevance 0.07
Localization of neprilysin (EC 3.4.24.11) mRNA in rat brain by in situ hybridization.
Localization (Localization) of neprilysin in brain associated with enkephalin
5) Confidence 0.78 Published 1993 Journal J. Neurosci. Res. Section Title Doc Link 8474144 Disease Relevance 0 Pain Relevance 0.20
[Regional distribution of enkephalinase in the rat brain by autoradiography].
Localization (distribution) of enkephalinase in brain
6) Confidence 0.75 Published 1984 Journal C. R. Acad. Sci. III, Sci. Vie Section Title Doc Link 6440665 Disease Relevance 0 Pain Relevance 0.16
At all spinal cord levels, enkephalinase was localized to discrete regions of the gray matter.
Localization (localized) of enkephalinase in gray matter associated with spinal cord
7) Confidence 0.75 Published 1989 Journal J. Comp. Neurol. Section Abstract Doc Link 2918102 Disease Relevance 0 Pain Relevance 0.22
In the lateral reticulated areas of lamina V, enkephalinase reaction product was localized to scattered medium-sized and large cells compressed against the white matter of axon bundles.
Localization (localized) of enkephalinase reaction product in lamina
8) Confidence 0.75 Published 1989 Journal J. Comp. Neurol. Section Abstract Doc Link 2918102 Disease Relevance 0 Pain Relevance 0.19
The antidiarrheal activity of enkephalinase inhibitors therefore seems attributable to protection of endogenous opioids, presumably outside the brain, and to reduction of intestinal secretion rather than transit.
Localization (secretion) of enkephalinase in brain associated with endogenous opioid
9) Confidence 0.75 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3481337 Disease Relevance 0.07 Pain Relevance 0.32
Immunoautoradiographic localisation of enkephalinase (EC 3.4.24.11) in rat gastrointestinal tract.
Localization (localisation) of enkephalinase associated with narcan
10) Confidence 0.74 Published 1991 Journal Neuropeptides Section Title Doc Link 1716743 Disease Relevance 0 Pain Relevance 0.14
Enkephalinase was localized by using a coupled enzyme assay based upon the sequential cleavage of the synthetic peptide substrate glutaryl-ala-ala-phe-4-methoxy-2-naphthylamide by enkephalinase and exogenous aminopeptidase M.
Localization (localized) of Enkephalinase in cleavage
11) Confidence 0.70 Published 1989 Journal J. Comp. Neurol. Section Abstract Doc Link 2918102 Disease Relevance 0 Pain Relevance 0.18
The localization of neutral endopeptidase-24.11 (E.C. 3.4.24.11; enkephalinase) in rat spinal cord was investigated by a novel fluorescent histochemical method.
Spec (investigated) Localization (localization) of enkephalinase in spinal cord associated with spinal cord
12) Confidence 0.70 Published 1989 Journal J. Comp. Neurol. Section Abstract Doc Link 2918102 Disease Relevance 0 Pain Relevance 0.15
We have developed a novel fluorescent histochemical method to localize the enzyme neutral endopeptidase-24.11 (NEP, E.C. 3.4.24.11, enkephalinase) in the rat brain in order to directly compare the relative distributions of the enzyme and its putative peptide substrate, the enkephalins.
Localization (localize) of enkephalinase in brain associated with enkephalin
13) Confidence 0.70 Published 1989 Journal J. Neurosci. Section Abstract Doc Link 2593007 Disease Relevance 0 Pain Relevance 0.17
Histochemical visualization of neutral endopeptidase-24.11 (enkephalinase) activity in rat brain: cellular localization and codistribution with enkephalins in the globus pallidus.
Localization (localization) of enkephalinase in globus pallidus associated with enkephalin
14) Confidence 0.70 Published 1989 Journal J. Neurosci. Section Title Doc Link 2593007 Disease Relevance 0.06 Pain Relevance 0.43
We have developed a novel fluorescent histochemical method to localize the enzyme neutral endopeptidase-24.11 (NEP, E.C. 3.4.24.11, enkephalinase) in the rat brain in order to directly compare the relative distributions of the enzyme and its putative peptide substrate, the enkephalins.
Localization (localize) of NEP in brain associated with enkephalin
15) Confidence 0.70 Published 1989 Journal J. Neurosci. Section Abstract Doc Link 2593007 Disease Relevance 0 Pain Relevance 0.17
Electron microscopic localization of immunoreactive enkephalinase (EC 3.4.24.11) in the neostriatum of the rat.
Localization (localization) of enkephalinase
16) Confidence 0.70 Published 1990 Journal J. Neurosci. Section Title Doc Link 2201754 Disease Relevance 0 Pain Relevance 0.04
The neuropeptides are degraded by peptidases, e.g., neutral endopeptidase (NEP) that is present in the nasal mucosa.
Localization (present) of NEP in nasal mucosa associated with neuropeptide
17) Confidence 0.70 Published 1998 Journal Am J Rhinol Section Abstract Doc Link 9578933 Disease Relevance 0 Pain Relevance 0.62
The cellular localization of the rat brain neutral endopeptidase (NEP, EC 3.4.24.11) was investigated by quantitative autoradiography of the enzyme inhibitor [3H]N-[(2RS)-3-hydroxyaminocarbonyl-2-benzyl-1-oxopropyl]glycine ([3H]HACBO-Gly) after lesions of the striatum, nigrostriatal and corticostriatal pathways.
Spec (investigated) Localization (localization) of neutral endopeptidase in striatum
18) Confidence 0.68 Published 1987 Journal Brain Res. Section Abstract Doc Link 2829989 Disease Relevance 0 Pain Relevance 0.07
This antibody was used to localize enkephalinase by autoradiographic and immunofluorescence techniques.
Localization (localize) of enkephalinase
19) Confidence 0.68 Published 1988 Journal Lab. Invest. Section Abstract Doc Link 3276960 Disease Relevance 0 Pain Relevance 0.09
At all levels of the brainstem, NEP was localized to cell bodies, cell processes or terminal-like fields and was localized to more than 90 distinct nuclei or subnuclei.
Localization (localized) of NEP in brainstem associated with medulla
20) Confidence 0.65 Published 1990 Journal J. Comp. Neurol. Section Abstract Doc Link 1694188 Disease Relevance 0 Pain Relevance 0.28

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