INT144534

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.62
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gem) plasma membrane (Gem) GTPase activity (Gem)
Anatomy Link Frequency
basal ganglia 1
T-cell 1
Gem (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 8 100.00 Very High Very High Very High
Inflammation 36 90.16 High High
Pain 1 86.60 High High
Central nervous system 15 80.12 Quite High
chemokine 3 46.16 Quite Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Demyelination 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Severe Combined Immunodeficiency 4 99.88 Very High Very High Very High
Cancer 46 99.72 Very High Very High Very High
Non-small-cell Lung Cancer 16 99.58 Very High Very High Very High
Apoptosis 60 91.28 High High
INFLAMMATION 39 90.16 High High
Repression 4 89.44 High High
Fatigue 1 87.08 High High
Pain 1 86.60 High High
Death 21 50.00 Quite Low
Infection 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 3A shows representative examples of Saa3, Lcn2 (N-GAL/24p3), Serpina3n, Gem, Cd83 and Tnfsf9 (4-1BBL) transcripts in the dorsal basal ganglia of mice that received saline injection, LPS or LPS/RU486; wherein the different pattern of expression is quite evident among transcripts.
Localization (examples) of Gem in basal ganglia
1) Confidence 0.37 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.09 Pain Relevance 0.04
Orthotopic growth of NSCLC tumors in SCID mice treated with GEM and PB chemotherapy
Localization (treated) of GEM associated with cancer, non-small-cell lung cancer and severe combined immunodeficiency
2) Confidence 0.30 Published 2006 Journal J Carcinog Section Body Doc Link PMC1665446 Disease Relevance 1.18 Pain Relevance 0
Blood samples were analysed for leukocyte subset cell counts, in vitro T-cell mitogen-stimulated cytokine production (IL-2, IL-4, IL-5, IL-6, IL-10, TNF-alpha and IFN-gamma) and in vitro monocyte cytokine release (IL-1beta, IL-6, IL-8, IL-10 and TNF-alpha) in response to increasing concentrations of LPS.
Localization (release) of T-cell mitogen-stimulated cytokine in T-cell associated with cytokine
3) Confidence 0.12 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17553664 Disease Relevance 0.35 Pain Relevance 0.37

General Comments

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