INT144535

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Context Info
Confidence 0.73
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 4.33
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (CES1)
Anatomy Link Frequency
cervical vertebra 1
T-cell 1
CES1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 5 100.00 Very High Very High Very High
Inflammation 3 85.52 High High
Pain 5 81.96 Quite High
alcohol 12 67.04 Quite High
Cervicogenic headache 4 50.00 Quite Low
epidural 3 50.00 Quite Low
Glutamate 6 34.92 Quite Low
cocaine 6 5.00 Very Low Very Low Very Low
lidocaine 6 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 263 99.92 Very High Very High Very High
Coronary Artery Disease 33 98.84 Very High Very High Very High
Chronic Disease 26 97.16 Very High Very High Very High
Death 18 93.80 High High
Cancer 28 93.56 High High
Emergencies 15 87.76 High High
Poisoning 7 86.32 High High
INFLAMMATION 3 85.52 High High
Dislocations 7 83.12 Quite High
Fatigue 1 82.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other key functional residues for human CES1 and CES2 have been retained by the opossum CES2 like enzymes, including the 'Z-site' (Gly356 for human CES1), which functions in cholesterol binding; the 'side door' residues at 424Val.Met425.Phe426; and the 'gate' residue 551Phe (for human CES1), both of which have either been retained or have undergone conservative substitution.
Localization (retained) of CES1
1) Confidence 0.73 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
Locations for Opossum CES1, CES2 and CES6 'Like' Genes on Chromosome 1
Localization (Locations) of CES1
2) Confidence 0.73 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
Other key functional residues for human CES1 and CES2 have been retained by the opossum CES2 like enzymes, including the 'Z-site' (Gly356 for human CES1), which functions in cholesterol binding; the 'side door' residues at 424Val.Met425.Phe426; and the 'gate' residue 551Phe (for human CES1), both of which have either been retained or have undergone conservative substitution.
Localization (retained) of CES1
3) Confidence 0.73 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
Other key functional residues for human CES1 and CES2 have been retained by the opossum CES2 like enzymes, including the 'Z-site' (Gly356 for human CES1), which functions in cholesterol binding; the 'side door' residues at 424Val.Met425.Phe426; and the 'gate' residue 551Phe (for human CES1), both of which have either been retained or have undergone conservative substitution.
Localization (retained) of CES1
4) Confidence 0.73 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
As mentioned previously, the N-glycosylation site reported for human CES1 (79–81: NAT) is retained for the opossum CES1 (NTT) and CES2.1 (NAT) sequences, but is absent from other opossum and human CES gene products, whereas opossum CES1 (2), CES2.1 (4), CES2.2 (1) and CES2.3 (1) have other potential glycosylation sites (Figure 3).
Localization (retained) of CES1
5) Confidence 0.64 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
As mentioned previously, the N-glycosylation site reported for human CES1 (79–81: NAT) is retained for the opossum CES1 (NTT) and CES2.1 (NAT) sequences, but is absent from other opossum and human CES gene products, whereas opossum CES1 (2), CES2.1 (4), CES2.2 (1) and CES2.3 (1) have other potential glycosylation sites (Figure 3).
Localization (retained) of CES1
6) Confidence 0.64 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Continuous epidural block of the cervical vertebra for patients with CEH is effective for at least six months.
Localization (block) of CEH in cervical vertebra
7) Confidence 0.63 Published 2009 Journal Chin. Med. J. Section Body Doc Link 19302749 Disease Relevance 0 Pain Relevance 0
Although it would not be appropriate to use neighbourhood SES solely to distinguish which CAD patients should be screened for other chronic diseases, we demonstrate that neighbourhood SES indices improved risk prediction for chronic disease mortality in these patients.
Localization (use) of SES associated with coronary artery disease and chronic disease
8) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2606022 Disease Relevance 1.38 Pain Relevance 0.03
Relationship between SES, gender, and types of childhood injuries
Localization (Relationship) of SES associated with injury
9) Confidence 0.57 Published 2006 Journal BMC Pediatr Section Body Doc Link PMC1687186 Disease Relevance 1.89 Pain Relevance 0
While it is notably difficult to comprehensively define SES, several studies commonly utilize proxies for SES, such as economically disadvantaged, limited education and social support.
Localization (support) of SES
10) Confidence 0.13 Published 2007 Journal The California Journal of Emergency Medicine Section Body Doc Link PMC2859736 Disease Relevance 0.73 Pain Relevance 0
Blood samples were analysed for leukocyte subset cell counts, in vitro T-cell mitogen-stimulated cytokine production (IL-2, IL-4, IL-5, IL-6, IL-10, TNF-alpha and IFN-gamma) and in vitro monocyte cytokine release (IL-1beta, IL-6, IL-8, IL-10 and TNF-alpha) in response to increasing concentrations of LPS.
Localization (release) of monocyte cytokine in T-cell associated with cytokine
11) Confidence 0.00 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17553664 Disease Relevance 0.33 Pain Relevance 0.35

General Comments

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