INT144537

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Context Info
Confidence 0.59
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0.63
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TPMT) small molecule metabolic process (TPMT) methyltransferase activity (TPMT)
cytoplasm (TPMT)
TPMT (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 20 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 8 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Naproxen (K(i) = 52 microM), mefenamic acid (K(i) = 39 microM), and tolfenamic acid (K(i) = 50 microM) inhibited TPMT activity in a noncompetitive manner.
Negative_regulation (inhibited) of TPMT
1) Confidence 0.59 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17553913 Disease Relevance 0.15 Pain Relevance 0.39
Inhibition of human thiopurine S-methyltransferase by various nonsteroidal anti-inflammatory drugs in vitro: a mechanism for possible drug interactions.
Spec (possible) Negative_regulation (Inhibition) of S-methyltransferase associated with inflammation and cinod
2) Confidence 0.51 Published 2007 Journal Drug Metab. Dispos. Section Title Doc Link 17553913 Disease Relevance 0.19 Pain Relevance 0.40
The estimated K(i) values for the inhibition of TPMT by ketoprofen (K(i) = 172 microM) and ibuprofen (K(i) = 1043 microM) indicated that the propionic acid derivatives were relatively weak inhibitors of TPMT.
Negative_regulation (inhibitors) of TPMT
3) Confidence 0.51 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17553913 Disease Relevance 0.14 Pain Relevance 0.38
The estimated K(i) values for the inhibition of TPMT by ketoprofen (K(i) = 172 microM) and ibuprofen (K(i) = 1043 microM) indicated that the propionic acid derivatives were relatively weak inhibitors of TPMT.
Negative_regulation (inhibition) of TPMT
4) Confidence 0.38 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17553913 Disease Relevance 0.15 Pain Relevance 0.39

General Comments

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