INT144538

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.87
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Mecp2) embryo development (Mecp2) DNA binding (Mecp2)
protein complex (Mecp2) response to stress (Mecp2) cytoplasm (Mecp2)
Anatomy Link Frequency
projection neurons 2
paw 2
dorsal horn 2
Mecp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 40 100.00 Very High Very High Very High
Dorsal horn 69 99.04 Very High Very High Very High
Pain 37 97.52 Very High Very High Very High
projection neuron 3 95.80 Very High Very High Very High
medulla 6 89.04 High High
IPN 13 75.00 Quite High
Dorsal horn neuron 1 71.28 Quite High
Spinal cord 4 60.24 Quite High
Hyperalgesia 1 59.76 Quite High
Thermal hyperalgesia 6 44.48 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 36 100.00 Very High Very High Very High
Repression 5 98.20 Very High Very High Very High
Pain 33 97.52 Very High Very High Very High
Injury 4 94.72 High High
Inflammatory Pain 13 75.00 Quite High
Neuropathic Pain 3 66.00 Quite High
Targeted Disruption 3 64.00 Quite High
Hyperalgesia 7 59.76 Quite High
Arthritis 6 5.00 Very Low Very Low Very Low
Hypersensitivity 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylation of MeCP2 regulates activity-dependent gene transcription, and crucially we found that MeCP2 was phosphorylated in lamina I projection neurons 1 h after induction of peripheral inflammation.
Regulation (regulates) of Phosphorylation (Phosphorylation) of MeCP2 in projection neurons associated with inflammation and projection neuron
1) Confidence 0.45 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17553988 Disease Relevance 0.89 Pain Relevance 0.79
Here, we describe how descending controls regulate MeCP2 phosphorylation (P-MeCP2), known to relieve transcriptional repression by MeCP2, and Zif268 and Fos expression in the rat superficial dorsal horn, after CFA injection into the hind paw.
Regulation (regulate) of Phosphorylation (phosphorylation) of MeCP2 in paw associated with repression and dorsal horn
2) Confidence 0.27 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2553762 Disease Relevance 0.48 Pain Relevance 0.47
Descending serotonergic controls regulate inflammation-induced mechanical sensitivity and methyl-CpG-binding protein 2 phosphorylation in the rat superficial dorsal horn

Background

Regulation (regulate) of Phosphorylation (phosphorylation) of methyl-CpG-binding protein 2 in dorsal horn associated with inflammation and dorsal horn
3) Confidence 0.23 Published 2008 Journal Mol Pain Section Title Doc Link PMC2553762 Disease Relevance 0.49 Pain Relevance 0.51

General Comments

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