INT144539

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Context Info
Confidence 0.82
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 13
Disease Relevance 6.18
Pain Relevance 6.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Mecp2) embryo development (Mecp2) DNA binding (Mecp2)
protein complex (Mecp2) response to stress (Mecp2) cytoplasm (Mecp2)
Anatomy Link Frequency
dorsal horn 4
projection neurons 2
paw 2
joint 1
lamina 1
Mecp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 199 99.96 Very High Very High Very High
Dorsal horn 369 99.84 Very High Very High Very High
projection neuron 6 99.48 Very High Very High Very High
Serotonin 66 98.20 Very High Very High Very High
Pain 186 97.52 Very High Very High Very High
intrathecal 77 94.40 High High
Arthritis 11 90.52 High High
Central nervous system 11 90.24 High High
IPN 61 89.96 High High
medulla 33 89.04 High High
Disease Link Frequency Relevance Heat
Arthritis 33 99.96 Very High Very High Very High
INFLAMMATION 177 99.92 Very High Very High Very High
Repression 24 98.56 Very High Very High Very High
Nociception 22 98.00 Very High Very High Very High
Pain 178 97.52 Very High Very High Very High
Injury 22 94.36 High High
Inflammatory Pain 61 89.96 High High
Hypersensitivity 33 89.04 High High
Retts Disease 11 86.08 High High
Targeted Disruption 13 76.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylation of MeCP2 regulates activity-dependent gene transcription, and crucially we found that MeCP2 was phosphorylated in lamina I projection neurons 1 h after induction of peripheral inflammation.
Phosphorylation (phosphorylated) of MeCP2 in projection neurons associated with inflammation and projection neuron
1) Confidence 0.82 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17553988 Disease Relevance 0.91 Pain Relevance 0.81
Phosphorylation of MeCP2 regulates activity-dependent gene transcription, and crucially we found that MeCP2 was phosphorylated in lamina I projection neurons 1 h after induction of peripheral inflammation.
Phosphorylation (Phosphorylation) of MeCP2 in projection neurons associated with inflammation and projection neuron
2) Confidence 0.82 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17553988 Disease Relevance 0.89 Pain Relevance 0.78
Phosphorylation of MeCP2 has been shown to de-repress BDNF expression [27], an increase in BDNF mRNA has been found in the dorsal horn after CFA injection [28] and intrathecal BDNF challenge has been shown to induce the transcription of c-fos within 90 min [29].


Phosphorylation (Phosphorylation) of MeCP2 in dorsal horn associated with dorsal horn and intrathecal
3) Confidence 0.80 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.25 Pain Relevance 0.36
We have previously reported that, after induction of peripheral joint inflammation, MeCP2 was phosphorylated in rat superficial dorsal horn and lamina I/III projection neurones, and that expression of SGK1, a protein under transcriptional repression by MeCP2, also expressed in lamina I/III projection neurones, increased in the superficial dorsal horn in an inflammatory pain state [7].
Phosphorylation (phosphorylated) of MeCP2 in joint associated with inflammation, ipn, repression, dorsal horn and arthritis
4) Confidence 0.80 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.73 Pain Relevance 0.63
We recently showed that MeCP2 was phosphorylated in the rat superficial dorsal horn after induction of peripheral joint inflammation, leading to an increase in expression of a family of genes under transcriptional control by MeCP2.
Phosphorylation (phosphorylated) of MeCP2 in dorsal horn associated with inflammation, dorsal horn and arthritis
5) Confidence 0.80 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.47 Pain Relevance 0.59
We found that phosphorylation of MeCP2 that follows CFA injection was decreased by serotonin depletion.
Phosphorylation (phosphorylation) of MeCP2 associated with serotonin
6) Confidence 0.80 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.61 Pain Relevance 0.51
In vitro, phosphorylation of MeCP2 at S421 was shown to lead to the displacement of MeCP2 from the BDNF promoter resulting in an increase in BDNF expression [6].
Phosphorylation (phosphorylation) of MeCP2
7) Confidence 0.62 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.35 Pain Relevance 0.48
Here, we describe how descending controls regulate MeCP2 phosphorylation (P-MeCP2), known to relieve transcriptional repression by MeCP2, and Zif268 and Fos expression in the rat superficial dorsal horn, after CFA injection into the hind paw.
Phosphorylation (phosphorylation) of P-MeCP2 in paw associated with repression and dorsal horn
8) Confidence 0.62 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2553762 Disease Relevance 0.48 Pain Relevance 0.50
MeCP2 phosphorylation after CFA injection in the hind paw is maximum in lamina I-II and 1 h after CFA injection
Phosphorylation (phosphorylation) of MeCP2 in lamina
9) Confidence 0.62 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0 Pain Relevance 0.07
The phosphorylation of MeCP2 in dorsal horn neurones following CFA was surprisingly slow compared to other transcription regulators such as cAMP response element-binding (CREB) and extracellular signal-regulated kinase (ERK) which are phosphorylated in dorsal horn neurones within 5 min of peripheral nociceptive stimulation [15,16].
Phosphorylation (phosphorylation) of MeCP2 in dorsal horn associated with nociception and dorsal horn
10) Confidence 0.62 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.27 Pain Relevance 0.29
However, the time course of phosphorylation of MeCP2 closely paralleled that of Zif268 and Fos expression, suggesting a common time course of regulation of gene expression for these 3 transcription factors.
Phosphorylation (phosphorylation) of MeCP2
11) Confidence 0.62 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.25 Pain Relevance 0.20
Here, we describe how descending controls regulate MeCP2 phosphorylation (P-MeCP2), known to relieve transcriptional repression by MeCP2, and Zif268 and Fos expression in the rat superficial dorsal horn, after CFA injection into the hind paw.
Phosphorylation (phosphorylation) of MeCP2 in paw associated with repression and dorsal horn
12) Confidence 0.62 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2553762 Disease Relevance 0.48 Pain Relevance 0.47
Descending serotonergic controls regulate inflammation-induced mechanical sensitivity and methyl-CpG-binding protein 2 phosphorylation in the rat superficial dorsal horn

Background

Phosphorylation (phosphorylation) of methyl-CpG-binding protein 2 in dorsal horn associated with inflammation and dorsal horn
13) Confidence 0.54 Published 2008 Journal Mol Pain Section Title Doc Link PMC2553762 Disease Relevance 0.49 Pain Relevance 0.51

General Comments

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