INT144541

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.43
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Mecp2) embryo development (Mecp2) DNA binding (Mecp2)
protein complex (Mecp2) response to stress (Mecp2) cytoplasm (Mecp2)
Anatomy Link Frequency
visceral 2
Mecp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 48 100.00 Very High Very High Very High
Spinal cord 21 98.78 Very High Very High Very High
Inflammation 26 98.36 Very High Very High Very High
Raphe 3 97.20 Very High Very High Very High
nud 19 95.20 Very High Very High Very High
medulla 9 86.44 High High
projection neuron 3 84.48 Quite High
intrathecal 7 79.60 Quite High
Acupuncture 40 77.36 Quite High
Dorsal horn neuron 1 75.84 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 24 98.36 Very High Very High Very High
Dyspepsia 20 95.20 Very High Very High Very High
Stress 12 94.62 High High
Inflammatory Pain 8 75.00 Quite High
Pain 32 72.08 Quite High
Neuropathic Pain 2 70.56 Quite High
Hyperalgesia 10 65.32 Quite High
Targeted Disruption 2 56.88 Quite High
Hypertrophy 1 52.96 Quite High
Peptic Ulcer 1 52.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A decrease in expression of SIN3A, a corepressor in the MeCP2 silencing complex, was also found after inflammation.
Negative_regulation (decrease) of Gene_expression (expression) of MeCP2 associated with inflammation
1) Confidence 0.42 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17553988 Disease Relevance 0.86 Pain Relevance 0.76
Interestingly, there was no difference in the ratio of P-MeCP2 neurones expressing Zif268 at 1 h and 2 h (78% ± 5% and 76% ± 5%, respectively) whereas the number of P-MeCP2 neurones expressing Fos increased slightly with time (82% ± 2% at 1 h and 90% ± 1% at 2 h, P < 0.05).


Negative_regulation (number) of Gene_expression (expressing) of P-MeCP2
2) Confidence 0.37 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.10 Pain Relevance 0.16
We have previously reported that neonatal maternal separation stress led to visceral hyperalgesia, which was associated with increased serotonergic activities at SDH of spinal cord and dorsal raphe nucleus.12 On the other hand, serotonergic depletion of the lumbar spinal cord with 5,7-DHT (5,7 di-hydroxytryptamine) creatinine sulphate reduced expression of transcription factors for dorsal horn neurone sensitization (eg, Fos and Methyl-CpG-binding protein 2) and significantly attenuated mechanical sensitivity after injection of Complete Freund's Adjuvant.40 These findings suggested that heightened serotonergic activities at SDH of spinal cord and DRN are responsible for visceral hyperalgesia.
Negative_regulation (reduced) of Gene_expression (expression) of Methyl-CpG-binding protein 2 in visceral associated with stress, dorsal horn, nud, raphe and spinal cord
3) Confidence 0.32 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912124 Disease Relevance 0.47 Pain Relevance 0.98

General Comments

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