INT144542

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Context Info
Confidence 0.68
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.43
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Mecp2) embryo development (Mecp2) DNA binding (Mecp2)
protein complex (Mecp2) response to stress (Mecp2) cytoplasm (Mecp2)
Anatomy Link Frequency
projection neurons 2
dorsal horn 2
Mecp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 36 100.00 Very High Very High Very High
Inflammation 23 100.00 Very High Very High Very High
projection neuron 3 100.00 Very High Very High Very High
Pain 21 90.64 High High
Central nervous system 1 83.20 Quite High
IPN 8 75.00 Quite High
Hyperalgesia 1 71.20 Quite High
Hippocampus 2 71.04 Quite High
addiction 1 67.32 Quite High
Dorsal horn neuron 1 67.20 Quite High
Disease Link Frequency Relevance Heat
Arthritis 3 100.00 Very High Very High Very High
INFLAMMATION 21 99.40 Very High Very High Very High
Pain 17 90.64 High High
Retts Disease 1 79.04 Quite High
Targeted Disruption 2 75.44 Quite High
Inflammatory Pain 8 75.00 Quite High
Hyperalgesia 4 71.20 Quite High
Neuropathic Pain 2 61.92 Quite High
Repression 3 5.00 Very Low Very Low Very Low
Hypersensitivity 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We recently showed that MeCP2 was phosphorylated in the rat superficial dorsal horn after induction of peripheral joint inflammation, leading to an increase in expression of a family of genes under transcriptional control by MeCP2.
Positive_regulation (leading) of Phosphorylation (phosphorylated) of MeCP2 in dorsal horn associated with inflammation, dorsal horn and arthritis
1) Confidence 0.68 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.49 Pain Relevance 0.62
Phosphorylation of MeCP2 regulates activity-dependent gene transcription, and crucially we found that MeCP2 was phosphorylated in lamina I projection neurons 1 h after induction of peripheral inflammation.
Positive_regulation (induction) of Phosphorylation (phosphorylated) of MeCP2 in projection neurons associated with inflammation and projection neuron
2) Confidence 0.50 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17553988 Disease Relevance 0.94 Pain Relevance 0.88

General Comments

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