INT14455

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Context Info
Confidence 0.72
First Reported 1989
Last Reported 2005
Negated 0
Speculated 2
Reported most in Abstract
Documents 17
Total Number 20
Disease Relevance 2.13
Pain Relevance 4.95

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methyltransferase activity (Pnmt) cytoplasm (Pnmt)
Anatomy Link Frequency
chromaffin cells 11
VLM 2
Pnmt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 2 99.88 Very High Very High Very High
Enkephalin 27 99.72 Very High Very High Very High
medulla 32 99.22 Very High Very High Very High
substance P 4 98.52 Very High Very High Very High
Clonidine 6 97.56 Very High Very High Very High
Morphine 10 96.48 Very High Very High Very High
cva 10 95.68 Very High Very High Very High
Catecholamine 17 94.72 High High
5HT 6 87.88 High High
Serotonin 8 87.68 High High
Disease Link Frequency Relevance Heat
Toxocariasis 10 99.22 Very High Very High Very High
Cv General 3 Under Development 8 95.68 Very High Very High Very High
Stress 11 88.48 High High
Attention Deficit Hyperactivity Disorder 2 76.76 Quite High
Cancer 4 75.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ontogenic expression of proenkephalin A (ProEnk A) mRNA and phenylethanolamine N-methyltransferase (PNMT) mRNA was examined in the foetal sheep adrenal medulla by the use of specific oligodeoxyribonucleotide probes.
Spec (examined) Transcription (expression) of phenylethanolamine N-methyltransferase in adrenal medulla associated with medulla
1) Confidence 0.72 Published 1989 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 2816486 Disease Relevance 0 Pain Relevance 0.12
Ether inhalation increased adrenal tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) mRNA expression as well as adrenal epinephrine (E) concentration in control rats but not in prenatally morphine-exposed (PM) animals.
Transcription (expression) of PNMT associated with morphine
2) Confidence 0.69 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15896472 Disease Relevance 0.31 Pain Relevance 0.69
Adrenal phenylethanolamine N-methyl-transferase (PNMT) mRNA levels were increased 4 h after both the PH and laparotomy and declined within 24 h.
Transcription (levels) of PNMT
3) Confidence 0.69 Published 1999 Journal Endocr Regul Section Body Doc Link 10700082 Disease Relevance 0 Pain Relevance 0
In vivo, PNMT and tyrosine hydroxylase (TH) mRNA levels increase in rat adrenal medulla after a single injection of clonidine.
Transcription (levels) of PNMT in adrenal medulla associated with medulla and clonidine
4) Confidence 0.69 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7643129 Disease Relevance 0 Pain Relevance 0.50
Ether inhalation increased adrenal tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) mRNA expression as well as adrenal epinephrine (E) concentration in control rats but not in prenatally morphine-exposed (PM) animals.
Transcription (expression) of phenylethanolamine N-methyltransferase associated with morphine
5) Confidence 0.69 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15896472 Disease Relevance 0.31 Pain Relevance 0.70
Using Northern blot analysis, adrenal phenylethanolamine N-methyltransferase (PNMT) mRNA expression was found to be reduced (P<0.005) fivefold in the cortisol infused foetuses when compared with the controls, as was the relative area of the adrenal medulla which stained positively with anti-PNMT (28.1+/-2.5% vs 44.8+/-4.8%, P<0.007).
Transcription (expression) of phenylethanolamine N-methyltransferase in adrenal medulla associated with medulla
6) Confidence 0.69 Published 1999 Journal J. Neuroendocrinol. Section Abstract Doc Link 10444314 Disease Relevance 0 Pain Relevance 0.09
The expression of proenkephalin A (ProEnk A) mRNA and phenylethanolamine N-methyltransferase (PNMT) mRNA in response to cAMP analogues, forskolin and phorbol esters was examined in cultures of bovine adrenal chromaffin cells.
Spec (examined) Transcription (expression) of phenylethanolamine N-methyltransferase in chromaffin cells
7) Confidence 0.63 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1850068 Disease Relevance 0.07 Pain Relevance 0
Developmental expression of proenkephalin A mRNA and phenylethanolamine N-methyltransferase mRNA in foetal sheep adrenal medulla.
Transcription (expression) of phenylethanolamine N-methyltransferase in adrenal medulla associated with medulla and enkephalin
8) Confidence 0.53 Published 1989 Journal Int. J. Dev. Neurosci. Section Title Doc Link 2816486 Disease Relevance 0 Pain Relevance 0.38
The aims of this study were, first to validate the utility of real-time RT-PCR SYBR Green assay for quantitation of mRNA expression levels of neuromessengers in small site-specific neuronal populations in the VLM, and second to compare the basal mRNA levels of the adrenaline-synthesizing enzyme phenylethanolamine-N-methyltransferase (PNMT), neuropeptide Y (NPY) and preproenkephalin (ENK) in the three regions and third to examine the effects of haemorrhage on the expression of these three genes.
Transcription (levels) of PNMT in VLM associated with medulla, neuropeptide and cva
9) Confidence 0.52 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12782392 Disease Relevance 0.64 Pain Relevance 0.53
Glucocorticoids decrease phenylethanolamine N-methyltransferase mRNA expression in the immature foetal sheep adrenal.
Transcription (expression) of phenylethanolamine N-methyltransferase associated with enkephalin
10) Confidence 0.51 Published 1999 Journal J. Neuroendocrinol. Section Title Doc Link 10444314 Disease Relevance 0 Pain Relevance 0.18
The effects of histamine on the regulation of proenkephalin A (ProEnk A) and phenylethanolamine N-methyltransferase (PNMT) mRNA expression were examined in cultures of bovine adrenal chromaffin cells.
Transcription (expression) of phenylethanolamine N-methyltransferase in chromaffin cells
11) Confidence 0.48 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2767138 Disease Relevance 0 Pain Relevance 0.07
The expression of proenkephalin A (ProEnk A) mRNA and phenylethanolamine N-methyltransferase (PNMT) mRNA in response to cAMP analogues, forskolin and phorbol esters was examined in cultures of bovine adrenal chromaffin cells.
Transcription (mRNA) of phenylethanolamine N-methyltransferase in chromaffin cells
12) Confidence 0.47 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1850068 Disease Relevance 0.08 Pain Relevance 0
Adrenal phenylethanolamine N-methyl-transferase (PNMT) mRNA levels were increased 4 h after both the PH and laparotomy and declined within 24 h.
Transcription (levels) of phenylethanolamine N-methyl-transferase
13) Confidence 0.44 Published 1999 Journal Endocr Regul Section Body Doc Link 10700082 Disease Relevance 0 Pain Relevance 0
The aims of this study were, first to validate the utility of real-time RT-PCR SYBR Green assay for quantitation of mRNA expression levels of neuromessengers in small site-specific neuronal populations in the VLM, and second to compare the basal mRNA levels of the adrenaline-synthesizing enzyme phenylethanolamine-N-methyltransferase (PNMT), neuropeptide Y (NPY) and preproenkephalin (ENK) in the three regions and third to examine the effects of haemorrhage on the expression of these three genes.
Transcription (levels) of adrenaline-synthesizing enzyme phenylethanolamine-N-methyltransferase in VLM associated with medulla, neuropeptide and cva
14) Confidence 0.43 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12782392 Disease Relevance 0.63 Pain Relevance 0.52
Histamine activates proenkephalin A mRNA but not phenylethanolamine N-methyltransferase mRNA expression in cultured bovine adrenal chromaffin cells.
Transcription (expression) of phenylethanolamine N-methyltransferase in chromaffin cells associated with enkephalin
15) Confidence 0.35 Published 1989 Journal Eur. J. Pharmacol. Section Title Doc Link 2767138 Disease Relevance 0 Pain Relevance 0.34
The effects of glucocorticoids on the expression of phenylethanolamine N-methyltransferase (PNMT) mRNA and proenkephalin A (ProEnk A) mRNA in cultures of bovine adrenal chromaffin cells were examined.
Transcription (expression) of phenylethanolamine N-methyltransferase in chromaffin cells
16) Confidence 0.26 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2767137 Disease Relevance 0 Pain Relevance 0.11
The effects of glucocorticoids on the expression of phenylethanolamine N-methyltransferase (PNMT) mRNA and proenkephalin A (ProEnk A) mRNA in cultures of bovine adrenal chromaffin cells were examined.
Transcription (mRNA) of phenylethanolamine N-methyltransferase in chromaffin cells
17) Confidence 0.25 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2767137 Disease Relevance 0 Pain Relevance 0.12
Long-term, gene transcription of phenylethanolamine-N-methyltransferase (PNMT) is exerted by glucocorticoids, and gene transcription of Proenkephalin-A by agents such as histamine, angiotensin II and VIP that increase cyclic AMP (cAMP).
Transcription (transcription) of phenylethanolamine-N-methyltransferase
18) Confidence 0.23 Published 1990 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 1694230 Disease Relevance 0.09 Pain Relevance 0.49
We have demonstrated that there are differential changes in the levels of tyrosine hydroxylase (TH), phenylethanolamine N-methyltransferase (PNMT), and proenkephalin A (Pro Enk A) mRNA in the fetal sheep adrenal during late gestation.
Transcription (levels) of phenylethanolamine N-methyltransferase
19) Confidence 0.23 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9648889 Disease Relevance 0 Pain Relevance 0
Induction of phenylethanolamine N-methyltransferase mRNA expression by glucocorticoids in cultured bovine adrenal chromaffin cells.
Transcription (expression) of phenylethanolamine N-methyltransferase in chromaffin cells
20) Confidence 0.20 Published 1989 Journal Eur. J. Pharmacol. Section Title Doc Link 2767137 Disease Relevance 0 Pain Relevance 0.12

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