INT144607

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Context Info
Confidence 0.61
First Reported 2007
Last Reported 2009
Negated 3
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 2.09
Pain Relevance 2.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Mapk7) cytosol (Mapk7) nucleus (Mapk7)
cell cycle (Mapk7) cytoplasm (Mapk7)
Anatomy Link Frequency
spinal cord 6
dorsal horn 4
spinal 2
paw 2
neuronal 1
Mapk7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 27 100.00 Very High Very High Very High
intrathecal 12 100.00 Very High Very High Very High
Spinal cord 10 100.00 Very High Very High Very High
Dorsal horn 3 100.00 Very High Very High Very High
Spontaneous pain 1 100.00 Very High Very High Very High
Hyperalgesia 5 98.24 Very High Very High Very High
sodium channel 1 97.72 Very High Very High Very High
Thermal hyperalgesia 3 95.68 Very High Very High Very High
glial activation 1 88.08 High High
Neuropathic pain 9 50.00 Quite Low
Disease Link Frequency Relevance Heat
Pain 14 100.00 Very High Very High Very High
Nociception 6 98.76 Very High Very High Very High
Hyperalgesia 8 98.24 Very High Very High Very High
Pressure And Volume Under Development 1 98.16 Very High Very High Very High
Neuropathic Pain 9 66.72 Quite High
Complex Regional Pain Syndromes 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CCI significantly increased the expression of pERK5 neurons in the ipsilateral spinal dorsal horn to injury, not in the contralateral spinal dorsal horn.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of pERK5 in dorsal horn
1) Confidence 0.61 Published 2009 Journal Neurol. Res. Section Body Doc Link 19426589 Disease Relevance 0.07 Pain Relevance 0
CCI significantly increased the expression of pERK5 neurons in the laminae I and II of ipsilateral spinal dorsal horn to injury, not in the contralateral spinal dorsal horn.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of pERK5 in dorsal horn
2) Confidence 0.61 Published 2009 Journal Neurol. Res. Section Body Doc Link 19426589 Disease Relevance 0.05 Pain Relevance 0
Suppression by intrathecal BmK IT2 on rat spontaneous pain behaviors and spinal c-Fos expression induced by formalin.
Positive_regulation (induced) of Gene_expression (Suppression) of BmK in spinal associated with pain, spontaneous pain and intrathecal
3) Confidence 0.50 Published 2007 Journal Brain Res. Bull. Section Title Doc Link 17562390 Disease Relevance 0.20 Pain Relevance 0.52
Intrathecal injection AS-ODN markedly suppressed the increase of CCI-induced pERK5, pCREB expression in the spinal cord.
Positive_regulation (induced) of Gene_expression (expression) of pERK5 in spinal cord
4) Confidence 0.44 Published 2009 Journal Neurol. Res. Section Body Doc Link 19426589 Disease Relevance 0 Pain Relevance 0
Intrathecal injection of l-NAME could also partially inhibit BmK venom-induced c-Fos expression in lumbar spinal cord at 2 h.
Positive_regulation (-) of Gene_expression (expression) of BmK in spinal cord associated with spinal cord and intrathecal
5) Confidence 0.20 Published 2008 Journal Toxicon Section Abstract Doc Link 18606430 Disease Relevance 0.42 Pain Relevance 0.63
Intrathecal injection of l-NAME could also partially inhibit BmK venom-induced c-Fos expression in lumbar spinal cord at 2 h.
Positive_regulation (induced) of Gene_expression (expression) of BmK in spinal cord associated with spinal cord and intrathecal
6) Confidence 0.14 Published 2008 Journal Toxicon Section Abstract Doc Link 18606430 Disease Relevance 0.42 Pain Relevance 0.63
The results showed that the number of neuronal NO synthase (nNOS) positive neurons significantly increased in superficial (I-II), deep (V-VI) dorsal horn laminae and the ventral gray laminae (VII-X), but not in the nucleus proprius (III and IV) of bilateral L4-L5 lumbar spinal cord after unilateral intraplantar injection of BmK venom from 2h to 7d.
Neg (not) Positive_regulation (increased) of in neurons Gene_expression (injection) of BmK in neuronal associated with dorsal horn and spinal cord
7) Confidence 0.13 Published 2008 Journal Toxicon Section Abstract Doc Link 18606430 Disease Relevance 0.34 Pain Relevance 0.44
Moreover, minocycline partially inhibited BmK venom-induced spinal c-Fos expression but lack of effects on BmK venom-induced paw edema.
Positive_regulation (induced) of Gene_expression (expression) of BmK in paw associated with pressure and volume under development
8) Confidence 0.11 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19782067 Disease Relevance 0.60 Pain Relevance 0.61

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