INT144617

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Context Info
Confidence 0.75
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 1.74
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (RHO) plasma membrane (RHO) signal transducer activity (RHO)
Anatomy Link Frequency
embryos 1
ganglion cell 1
T cells 1
RHO (Homo sapiens)
RHO - P347S (1)
Pain Link Frequency Relevance Heat
Glutamate 88 99.76 Very High Very High Very High
Cannabinoid receptor 2 81.08 Quite High
cINOD 1 65.60 Quite High
Cholecystokinin 7 37.20 Quite Low
Somatostatin 18 29.36 Quite Low
chemokine 33 28.48 Quite Low
Pain 3 27.00 Quite Low
Analgesic 1 25.00 Low Low
Neuropeptide 26 5.00 Very Low Very Low Very Low
Glutamate receptor 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 159 99.34 Very High Very High Very High
Targeted Disruption 4 98.56 Very High Very High Very High
Retina Disease 13 98.44 Very High Very High Very High
Apoptosis 4 95.92 Very High Very High Very High
Ganglion Cysts 7 94.68 High High
Stress 5 92.32 High High
Disease 20 91.88 High High
INFLAMMATION 1 65.36 Quite High
Retinal Diseases 9 27.92 Quite Low
Pain 3 27.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The archaebacteria that express halorhodopsins typically live in environments with very high chloride concentrations (e.g., 1–5 M), and use halorhodopsin to pump chloride into the cell (even against the membrane potential) in order to maintain osmotic balance and accordingly reduce energy expenditure.
Gene_expression (express) of rhodopsin
1) Confidence 0.75 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1808431 Disease Relevance 0 Pain Relevance 0
Western blotting techniques showed that SNP caused a significant decrease in photoreceptor-specific markers (RET-P1, rhodopsin kinase), an increase in cleaved caspase-3, Bcl-2, and cleaved PARP proteins that are associated with apoptosis and no change in the ganglion cell specific marker, neurofilament (NF-L).
Gene_expression (decrease) of rhodopsin in ganglion cell associated with ganglion cysts and apoptosis
2) Confidence 0.65 Published 2007 Journal Brain Res. Bull. Section Abstract Doc Link 17562394 Disease Relevance 0.27 Pain Relevance 0
Finally, we demonstrated that pomalidomide was able to regulate the activity of Rho GTPases and the formation of F-actin in primary human T cells as it did in monocytes and showed that the activation of RhoA was essential for pomalidomide-induced interleukin-2 expression in T cells.
Gene_expression (activity) of Rho in T cells
3) Confidence 0.65 Published 2009 Journal Blood Section Abstract Doc Link 19417207 Disease Relevance 0.16 Pain Relevance 0.07
Structural Innovations in the Ciona LDLRR/LGR-like/GLHR Rhodopsin cluster
Gene_expression (cluster) of Rhodopsin
4) Confidence 0.39 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2396169 Disease Relevance 0 Pain Relevance 0.08
It is also interesting to note that the proteins in the Rhodopsin family ?
Gene_expression (family) of Rhodopsin
5) Confidence 0.32 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1472694 Disease Relevance 0.14 Pain Relevance 0
The chicken GPCR dataset was divided into Adhesion, Frizzled, Glutamate, Secretin, Rhodopsin, and Taste 2 families based on the human dataset.
Gene_expression (families) of Rhodopsin associated with glutamate and adhesions
6) Confidence 0.32 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1472694 Disease Relevance 0.10 Pain Relevance 0.05
 ; 69.2 (Rhodopsin ?)
Gene_expression (69.2) of Rhodopsin
7) Confidence 0.32 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1472694 Disease Relevance 0.17 Pain Relevance 0.05
The large Rhodopsin family was further subdivided into ?
Gene_expression (family) of Rhodopsin
8) Confidence 0.32 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1472694 Disease Relevance 0.10 Pain Relevance 0.05
 ; 77.3 (Rhodopsin ?)
Gene_expression (77.3) of Rhodopsin
9) Confidence 0.32 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1472694 Disease Relevance 0.17 Pain Relevance 0.05
The Rhodopsin family can be divided in four main groups (?
Gene_expression (family) of Rhodopsin
10) Confidence 0.20 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2246102 Disease Relevance 0.09 Pain Relevance 0.04
The Rhodopsin family of GPCRs constitutes the largest family of GPCRs in vertebrates (Fig. 3).
Gene_expression (family) of Rhodopsin
11) Confidence 0.20 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2246102 Disease Relevance 0 Pain Relevance 0
The retinal degeneration patterns observed in aggregation embryos created from normal and mutant mice expressing mutant rhodopsin (Pro347Ser) [51] and in hemizygous transgenic female rds?
Gene_expression (expressing) of rhodopsin (P347S) in embryos associated with targeted disruption and retina disease
12) Confidence 0.04 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1463903 Disease Relevance 0.56 Pain Relevance 0
Within the GPCR super-family, bovine rhodopsin has 18% sequence identity to the human adrenergic ?
Gene_expression (has) of rhodopsin
13) Confidence 0.04 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0

General Comments

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