INT144618

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.57
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL11A2) cell adhesion (COL11A2) structural molecule activity (COL11A2)
protein binding, bridging (COL11A2)
Anatomy Link Frequency
ganglion cell 1
TEK 1
COL11A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 12 100.00 Very High Very High Very High
Analgesic 1 25.00 Low Low
antagonist 7 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
spinal inflammation 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Opioid 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 124 98.76 Very High Very High Very High
Apoptosis 77 98.60 Very High Very High Very High
Breast Cancer 46 97.84 Very High Very High Very High
Ganglion Cysts 2 97.36 Very High Very High Very High
Disease 13 80.56 Quite High
Spinal Cord Diseases 2 76.24 Quite High
Death 22 74.96 Quite High
Heterotopic Ossification 15 70.84 Quite High
Ductal Carcinoma 2 56.92 Quite High
Malignant Neoplastic Disease 4 53.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blotting techniques showed that SNP caused a significant decrease in photoreceptor-specific markers (RET-P1, rhodopsin kinase), an increase in cleaved caspase-3, Bcl-2, and cleaved PARP proteins that are associated with apoptosis and no change in the ganglion cell specific marker, neurofilament (NF-L).
Gene_expression (decrease) of PARP in ganglion cell associated with ganglion cysts and apoptosis
1) Confidence 0.65 Published 2007 Journal Brain Res. Bull. Section Abstract Doc Link 17562394 Disease Relevance 0.28 Pain Relevance 0
On the other hand, right branch shows overexpression areas with genes such as CASP 10, CD30-L, and CD-40-L (TNF family), ras-like small, FGF 3 and 5, TDGF1, ERK5, MIF, IFNGR2, MIG, IFN-alpha, beta, gamma, IL-3, -4, -9 and -13, IP-10, HPRT, DCC, TEK, netrin-2, cadherins 4, 8, 12 and 13 [33], MMP3, 8, 10, 12 and 13 (metalloproteinase), COL11A2, CCNG1, CDC-6, ATM, N-MYC, and p53.
Gene_expression (overexpression) of COL11A2 in TEK associated with metalloproteinase
2) Confidence 0.55 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.89 Pain Relevance 0.05
In this group, we found some overexpressed genes; of these, COL11A2 and netrin-2 had not been previously associated with breast cancer.
Gene_expression (overexpressed) of COL11A2 associated with breast cancer
3) Confidence 0.55 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 1.11 Pain Relevance 0
Therefore, multiple rather than single, dominant genes, including COL11, BMP-2, TGF-?
Gene_expression (including) of COL11
4) Confidence 0.31 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.30 Pain Relevance 0

General Comments

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