INT144646

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 53
Total Number 54
Disease Relevance 27.78
Pain Relevance 13.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Rela) nucleus (Rela) DNA binding (Rela)
protein complex (Rela) transcription factor binding (Rela) cytoplasm (Rela)
Anatomy Link Frequency
DRG 4
nucleus 3
microglia 2
dopaminergic neurons 2
lung 2
Rela (Mus musculus)
Pain Link Frequency Relevance Heat
Substantia nigra 407 100.00 Very High Very High Very High
Inflammatory mediators 33 100.00 Very High Very High Very High
Morphine 312 99.98 Very High Very High Very High
Inflammatory response 91 98.68 Very High Very High Very High
dorsal root ganglion 20 98.66 Very High Very High Very High
Inflammation 594 98.40 Very High Very High Very High
Spinal cord 29 98.28 Very High Very High Very High
cytokine 540 97.36 Very High Very High Very High
metalloproteinase 50 97.32 Very High Very High Very High
cINOD 67 97.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 708 100.00 Very High Very High Very High
Stress 107 99.98 Very High Very High Very High
Cancer 312 99.80 Very High Very High Very High
Apoptosis 245 99.52 Very High Very High Very High
Parkinson's Disease 354 99.28 Very High Very High Very High
Injury 237 99.28 Very High Very High Very High
Disease 621 99.20 Very High Very High Very High
Ganglion Cysts 37 98.66 Very High Very High Very High
Uveitis 43 98.56 Very High Very High Very High
Infection 172 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induction of DRG mGlu2 receptors in response to SAHA was associated with increased acetylation of p65/RelA on lysine 310, a process that enhances the transcriptional activity of p65/RelA at nuclear factor-kappaB-regulated genes.
Positive_regulation (enhances) of p65 in DRG associated with dorsal root ganglion
1) Confidence 0.67 Published 2009 Journal Mol. Pharmacol. Section Abstract Doc Link 19255242 Disease Relevance 0.65 Pain Relevance 0.94
Induction of DRG mGlu2 receptors in response to SAHA was associated with increased acetylation of p65/RelA on lysine 310, a process that enhances the transcriptional activity of p65/RelA at nuclear factor-kappaB-regulated genes.
Positive_regulation (acetylation) of p65 in DRG associated with dorsal root ganglion
2) Confidence 0.49 Published 2009 Journal Mol. Pharmacol. Section Abstract Doc Link 19255242 Disease Relevance 0.65 Pain Relevance 0.93
Induction of DRG mGlu2 receptors in response to SAHA was associated with increased acetylation of p65/RelA on lysine 310, a process that enhances the transcriptional activity of p65/RelA at nuclear factor-kappaB-regulated genes.
Positive_regulation (acetylation) of RelA in DRG associated with dorsal root ganglion
3) Confidence 0.49 Published 2009 Journal Mol. Pharmacol. Section Abstract Doc Link 19255242 Disease Relevance 0.65 Pain Relevance 0.93
Induction of DRG mGlu2 receptors in response to SAHA was associated with increased acetylation of p65/RelA on lysine 310, a process that enhances the transcriptional activity of p65/RelA at nuclear factor-kappaB-regulated genes.
Positive_regulation (activity) of RelA in DRG associated with dorsal root ganglion
4) Confidence 0.49 Published 2009 Journal Mol. Pharmacol. Section Abstract Doc Link 19255242 Disease Relevance 0.65 Pain Relevance 0.93
In addition, the levels of phospho-p65 were significantly increased in WT mice 24 h after IR injury, as demonstrated by western blot (Figure 2B).
Positive_regulation (increased) of p65 associated with injury
5) Confidence 0.43 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956702 Disease Relevance 0.36 Pain Relevance 0.10
Transcriptional upregulation of the p65 (RelA) subunit of NF-?
Positive_regulation (upregulation) of RelA
6) Confidence 0.43 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956702 Disease Relevance 0.54 Pain Relevance 0.21
Transcriptional upregulation of the p65 (RelA) subunit of NF-?
Positive_regulation (upregulation) of p65
7) Confidence 0.43 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956702 Disease Relevance 0.53 Pain Relevance 0.21
PEA attenuated the development of carrageenan-induced paw edema, we evaluated inhibitor kappaB-alpha (I kappa B-alpha) degradation and nuclear factor-kappaB (NF-kappaB) p65 activation in the cytosolic or nuclear extracts from spinal cord tissue.
Positive_regulation (activation) of p65 in spinal cord associated with pressure and volume under development and spinal cord
8) Confidence 0.38 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17565008 Disease Relevance 0.51 Pain Relevance 0.49
increased nuclear p65 (RelA) in dopaminergic neurons when compared to age
Positive_regulation (increased) of RelA in dopaminergic neurons
9) Confidence 0.37 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490815 Disease Relevance 0.68 Pain Relevance 0.51
increased nuclear p65 (RelA) in dopaminergic neurons when compared to age
Positive_regulation (increased) of p65 in dopaminergic neurons
10) Confidence 0.37 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490815 Disease Relevance 0.68 Pain Relevance 0.51
Buffering [Ca2+]i with BAPTA/AM significantly delays nuclear import, while artificially elevating Ca2+ by excessive (5 mM) Ca2+ outside the cell accelerates p65 (RelA) subunit trafficking into the nucleus.
Positive_regulation (accelerates) of RelA in nucleus
11) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.06 Pain Relevance 0.55
Buffering [Ca2+]i with BAPTA/AM significantly delays nuclear import, while artificially elevating Ca2+ by excessive (5 mM) Ca2+ outside the cell accelerates p65 (RelA) subunit trafficking into the nucleus.
Positive_regulation (accelerates) of p65 in nucleus
12) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.06 Pain Relevance 0.52
Chelating [Ca2+]i prevented Tat±morphine-induced p65/NF-?
Positive_regulation (induced) of p65 associated with morphine
13) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.20 Pain Relevance 0.94
R-/- mice produced no apparent accumulation of p65 (Figure 2A-H).
Neg (no) Positive_regulation (accumulation) of p65
14) Confidence 0.30 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0 Pain Relevance 0.04
B activation (p65 and p50) as well as a typical marker for neuroinflammation, intercellular adhesion molecule 1 (ICAM-1).
Positive_regulation (activation) of p65 associated with adhesions
15) Confidence 0.30 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0.19 Pain Relevance 0.28
The transcriptional activation of p65 and p50, the accumulation of p65 protein, and the induction of ICAM-1 were all attenuated in the Fc?
Positive_regulation (activation) of p65
16) Confidence 0.30 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0 Pain Relevance 0.03
In MPTP treated mice, there is also marked accumulation of p65 in microglia, and activation of NF-?
Positive_regulation (accumulation) of p65 in microglia associated with parkinson's disease
17) Confidence 0.30 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0.50 Pain Relevance 0.19
B p65 was decreased, rather than increased, in the Fc?
Positive_regulation (increased) of p65
18) Confidence 0.30 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0.22 Pain Relevance 0.16
R blocks the transcriptional induction of p65, p50, and ICAM-1, prevents microglial p65 accumulation.
Positive_regulation (induction) of p65
19) Confidence 0.28 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0.24 Pain Relevance 0.14
R blocks the transcriptional induction of p65, p50, and ICAM-1, prevents microglial p65 accumulation.
Positive_regulation (accumulation) of p65
20) Confidence 0.28 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0.25 Pain Relevance 0.14

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