INT144649

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Context Info
Confidence 0.26
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 8.27
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Rela) nucleus (Rela) DNA binding (Rela)
protein complex (Rela) transcription factor binding (Rela) cytoplasm (Rela)
Anatomy Link Frequency
macrophage 2
spinal cord 2
microglia 2
Rela (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 2 98.28 Very High Very High Very High
Inflammation 141 97.88 Very High Very High Very High
metalloproteinase 25 97.32 Very High Very High Very High
dopaminergic neurodegeneration 11 95.84 Very High Very High Very High
Inflammatory response 14 95.08 Very High Very High Very High
Substantia nigra 74 94.96 High High
cINOD 27 94.32 High High
cytokine 50 90.48 High High
agonist 6 85.40 High High
cerebral cortex 2 84.96 Quite High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 6 99.90 Very High Very High Very High
Parkinson's Disease 132 99.70 Very High Very High Very High
Stress 39 99.60 Very High Very High Very High
INFLAMMATION 161 97.88 Very High Very High Very High
Myocardial Infarction 27 97.00 Very High Very High Very High
Aging 26 96.24 Very High Very High Very High
Disease 110 95.92 Very High Very High Very High
Cancer 114 94.92 High High
Apoptosis 69 94.56 High High
Hypertrophy 10 92.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
R blocks the transcriptional induction of p65, p50, and ICAM-1, prevents microglial p65 accumulation.
Negative_regulation (prevents) of Positive_regulation (accumulation) of p65
1) Confidence 0.26 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0.25 Pain Relevance 0.14
In MPTP treated mice, there is also marked accumulation of p65 in microglia, and activation of NF-?
Negative_regulation (there) of Positive_regulation (accumulation) of p65 in microglia associated with parkinson's disease
2) Confidence 0.26 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0.50 Pain Relevance 0.19
PEA attenuated the development of carrageenan-induced paw edema, we evaluated inhibitor kappaB-alpha (I kappa B-alpha) degradation and nuclear factor-kappaB (NF-kappaB) p65 activation in the cytosolic or nuclear extracts from spinal cord tissue.
Negative_regulation (evaluated) of Positive_regulation (activation) of p65 in spinal cord associated with pressure and volume under development and spinal cord
3) Confidence 0.23 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17565008 Disease Relevance 0.53 Pain Relevance 0.56
B kinase inhibitor, leading to downstream loss of NFkB activation, marginally improved left ventricular function and reduced matrix metalloproteinase activity 28 days later [56].
Negative_regulation (loss) of Positive_regulation (activation) of NFkB associated with metalloproteinase
4) Confidence 0.15 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 0.75 Pain Relevance 0.10
In the present study, we found that LPS-induced COX-2 expression and p65 activation was inhibited by pretreatment with CoPP and CO-RM2, suggesting that induction of HO-1/CO inhibits LPS-induced COX-2 by inhibition of NF-?
Negative_regulation (inhibited) of Positive_regulation (activation) of p65
5) Confidence 0.11 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.30 Pain Relevance 0.12
Activated GC receptors (GRs) are able to interfere with the transactivation potential of the p65 NF-?
Negative_regulation (interfere) of Positive_regulation (potential) of p65
6) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.42 Pain Relevance 0.28
Moreover curcumin suppresses the activation of several transcription factors that are implicated in carcinogenesis: it suppresses the activation of nuclear factor kappa B (NFkB), activator protein 1 (AP-1), and at least two of the signal transducer and activator of transcription proteins (STAT3, STAT5).
Negative_regulation (suppresses) of Positive_regulation (activation) of nuclear factor kappa B
7) Confidence 0.06 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 1.27 Pain Relevance 0.06
Moreover curcumin suppresses the activation of several transcription factors that are implicated in carcinogenesis: it suppresses the activation of nuclear factor kappa B (NFkB), activator protein 1 (AP-1), and at least two of the signal transducer and activator of transcription proteins (STAT3, STAT5).
Negative_regulation (suppresses) of Positive_regulation (activation) of NFkB
8) Confidence 0.04 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 1.27 Pain Relevance 0.06
In their study, Idris and co [64] reported the ability of HCT1026 to inhibit receptor activator of NFkB (RANKL), as well as RANKL-induced activation of NFkB and ERK pathway in LPS-stimulated macrophage cultures.
Negative_regulation (inhibit receptor activator) of Positive_regulation (activation) of NFkB in macrophage
9) Confidence 0.03 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.24 Pain Relevance 0.36
Interestingly, the dose–effect relationship between level of oxidative stress and NFkB exhibits a biphasic profile: while moderate levels of oxidative stress activate NFkB through an IkB kinase independent mechanism, extremely high levels of oxidative stress have been shown to inhibit NFkB activation by blocking IkB?
Negative_regulation (inhibit) of Positive_regulation (activation) of NFkB associated with stress
10) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2910505 Disease Relevance 1.37 Pain Relevance 0
phosphorylation, thereby resulting in a decline in NFkB activation.
Negative_regulation (decline) of Positive_regulation (activation) of NFkB
11) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2910505 Disease Relevance 1.37 Pain Relevance 0

General Comments

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