INT144677

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.59
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hspa5) endoplasmic reticulum (Hspa5) nucleus (Hspa5)
Hspa5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 1 97.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Death 4 88.64 High High
Stress 4 84.16 Quite High
Toxicity 1 70.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
XBP1 signaling was observed with all three drugs and was associated with increased expression of GRP94 and GRP78 in GEN- and PAP-treated animals, but surprisingly not after CIS exposure. m-Calpain expression was increased after 7 days of CIS treatment, whereas it was decreased in PAP-treated rats.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of GRP78
1) Confidence 0.04 Published 2007 Journal Toxicol. Sci. Section Abstract Doc Link 17567590 Disease Relevance 0.59 Pain Relevance 0.10

General Comments

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