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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.59
Pain Relevance 0.10

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unfolded protein binding (Hspa5) endoplasmic reticulum (Hspa5) nucleus (Hspa5)
Hspa5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 1 97.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Death 4 88.64 High High
Stress 4 84.16 Quite High
Toxicity 1 70.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
XBP1 signaling was observed with all three drugs and was associated with increased expression of GRP94 and GRP78 in GEN- and PAP-treated animals, but surprisingly not after CIS exposure. m-Calpain expression was increased after 7 days of CIS treatment, whereas it was decreased in PAP-treated rats.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of GRP78
1) Confidence 0.04 Published 2007 Journal Toxicol. Sci. Section Abstract Doc Link 17567590 Disease Relevance 0.59 Pain Relevance 0.10

General Comments

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