INT144683

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Context Info
Confidence 0.26
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.88
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Rtn4r) plasma membrane (Rtn4r)
Anatomy Link Frequency
pyramidal neurons 1
astrocytes 1
oligodendrocyte 1
Rtn4r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pyramidal cell 1 99.96 Very High Very High Very High
Spinal cord 25 91.44 High High
amygdala 6 82.72 Quite High
antagonist 9 73.28 Quite High
corticosteroid 98 50.00 Quite Low
dexamethasone 3 37.44 Quite Low
Pain 2 25.00 Low Low
Central nervous system 12 9.56 Low Low
Hippocampus 18 5.00 Very Low Very Low Very Low
Glutamate 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Spinal Cord Injury 63 99.24 Very High Very High Very High
Cicatrix 23 98.00 Very High Very High Very High
Frailty 4 91.20 High High
Neurodegenerative Disease 4 90.40 High High
Overactive Bladder 1 73.20 Quite High
Shock 8 50.80 Quite High
Injury 50 20.72 Low Low
Stress 46 5.00 Very Low Very Low Very Low
Apoptosis 15 5.00 Very Low Very Low Very Low
Depression 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Notably, membrane-associated immunoreactive nGR sites were observed in or near membranes covering the dendrites and somata of pyramidal neurons; nGR immunoreactivity was also seen in the vicinity of the Golgi complex.
Regulation (immunoreactivity) of nGR in pyramidal neurons associated with pyramidal cell
1) Confidence 0.26 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0 Pain Relevance 0.09
Blocking a novel Nogo receptor interacting mechanism and/or effects of EGFR inhibition on astrocytes may underlie these effects.
Regulation (effects) of Nogo receptor in astrocytes
2) Confidence 0.20 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17567803 Disease Relevance 0.41 Pain Relevance 0.15
All these studies highlight the role of myelin/oligodendrocyte inhibitory molecules in inhibition of regeneration in axons and the importance of targeting the NgR when dealing with SCI.


Regulation (targeting) of NgR in oligodendrocyte associated with spinal cord injury
3) Confidence 0.05 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3019362 Disease Relevance 0.47 Pain Relevance 0.12

General Comments

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