INT144696

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 2.96
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) aging (Bcl2) cell morphogenesis (Bcl2)
endoplasmic reticulum (Bcl2) intracellular (Bcl2) response to stress (Bcl2)
Anatomy Link Frequency
mononuclear cells 4
bone marrow 2
apoptotic cells 2
Bcl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 43 99.84 Very High Very High Very High
Inflammation 6 89.40 High High
Pain 7 76.28 Quite High
Morphine 3 50.00 Quite Low
ischemia 10 46.16 Quite Low
withdrawal 7 31.28 Quite Low
cytokine 11 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
nud 3 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 143 100.00 Very High Very High Very High
Death 40 97.68 Very High Very High Very High
Leukemia 26 95.08 Very High Very High Very High
Stress 7 92.44 High High
Glioblastoma 5 91.12 High High
INFLAMMATION 8 89.40 High High
Pain 7 76.28 Quite High
Pressure And Volume Under Development 8 75.92 Quite High
Toxicity 14 61.56 Quite High
Solid Tumor 18 59.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Developmental A1254 exposure had no effect on cortical or striatal levels of Bcl2 mRNA in either sex at PND7 (Figure 5A,C).
Neg (no) Regulation (effect) of Transcription (levels) of Bcl2
1) Confidence 0.44 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.12 Pain Relevance 0
Among the 8 patients, downregulation of bcl-2 mRNA in bone marrow was observed in 4 patients; bcl-2 mRNA was unchanged in 2 patients and increased in 2 patients.
Neg (unchanged) Regulation (unchanged) of Transcription (mRNA) of bcl-2 in bone marrow
2) Confidence 0.36 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376092 Disease Relevance 0.20 Pain Relevance 0
These same investigators assessed the relationship between clinical response, plasma and intracellular oblimersen levels, and changes in bcl-2 mRNA and Bcl-2 protein levels in bone marrow mononuclear cells in 22 elderly patients treated with oblimersen and chemotherapy for previously untreated acute myeloid leukemia (Marcucci et al 2005).
Regulation (changes) of Transcription (levels) of Bcl-2 in mononuclear cells associated with leukemia
3) Confidence 0.36 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376092 Disease Relevance 0.22 Pain Relevance 0
These same investigators assessed the relationship between clinical response, plasma and intracellular oblimersen levels, and changes in bcl-2 mRNA and Bcl-2 protein levels in bone marrow mononuclear cells in 22 elderly patients treated with oblimersen and chemotherapy for previously untreated acute myeloid leukemia (Marcucci et al 2005).
Regulation (changes) of Transcription (levels) of bcl-2 in mononuclear cells associated with leukemia
4) Confidence 0.36 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376092 Disease Relevance 0.22 Pain Relevance 0
Expressions of Bax and Bcl-2 at mRNA and protein levels were altered resulting in an increase in Bax : Bcl-2 ratio in apoptotic cells, which also exhibited overexpression of 80 kDa calpain and an increase in calpain-cleaved 145 kDa alpha-spectrin breakdown product.
Regulation (altered) of Transcription (mRNA) of Bcl-2 in apoptotic cells associated with apoptosis
5) Confidence 0.24 Published 2007 Journal Neurochem. Res. Section Abstract Doc Link 17570061 Disease Relevance 1.64 Pain Relevance 0.23
In the present study, 72-hour preincubation of PC12 cells with 1.2 mM lithium chloride reversed the effects of morphine on the mRNA expression of BAX and BCL-2.
Regulation (effects) of Transcription (expression) of BCL-2
6) Confidence 0.24 Published 2008 Journal Arch Iran Med Section Body Doc Link 18976035 Disease Relevance 0 Pain Relevance 0
Instead, Dex up-regulated the expression of Bcl-XL, IAP-2 and XIAP, while the transcript levels of the anti-apoptotic proteins Bcl-2, IAP-1, FLIPLong and FLIPShort were unaltered by Dex treatment.
Regulation (unaltered) of Transcription (levels) of anti-apoptotic proteins Bcl-2 associated with apoptosis and dexamethasone
7) Confidence 0.09 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.56 Pain Relevance 0.28

General Comments

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