INT144697

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Context Info
Confidence 0.37
First Reported 2002
Last Reported 2010
Negated 5
Speculated 4
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 9.50
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax)
cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)
Anatomy Link Frequency
liver 4
brain 2
apoptotic cells 2
Bax (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 39 90.32 High High
ischemia 95 88.96 High High
Pain 2 77.20 Quite High
cva 1 73.88 Quite High
dexamethasone 41 67.32 Quite High
Pyramidal cell 24 61.40 Quite High
anesthesia 14 55.60 Quite High
cytokine 7 54.48 Quite High
Mechanotransduction 1 22.76 Low Low
depression 1 20.72 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 353 100.00 Very High Very High Very High
Cancer 5 100.00 Very High Very High Very High
Status Epilepticus 57 99.72 Very High Very High Very High
Death 54 98.40 Very High Very High Very High
Middle Cerebral Artery Infarction 1 95.32 Very High Very High Very High
Diabetes Mellitus 9 93.40 High High
Stress 67 93.36 High High
Glioblastoma 5 92.04 High High
INFLAMMATION 51 90.32 High High
Pancreatitis 39 89.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The observation that neither the Bax:Bcl-2 nor the Bax:Bcl-xL ratios are regulated at a time when apoptosis is already detectable (3 h) suggests that Bcl-2-related family members are not associated with early cell death following I/R.
Neg (neither) Regulation (regulated) of Gene_expression (ratios) of Bax associated with apoptosis and death
1) Confidence 0.37 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.56 Pain Relevance 0.07
The observation that neither the Bax:Bcl-2 nor the Bax:Bcl-xL ratios are regulated at a time when apoptosis is already detectable (3 h) suggests that Bcl-2-related family members are not associated with early cell death following I/R.
Neg (neither) Regulation (regulated) of Gene_expression (ratios) of Bax associated with apoptosis and death
2) Confidence 0.37 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.56 Pain Relevance 0.07
To further investigate whether arsenic exposure affects the expression of Bcl-2 and Bax at the mRNA levels, transcription levels of Bcl-2 and Bax were checked in the liver tissue of the experimental rats.
Spec (whether) Regulation (affects) of Gene_expression (expression) of Bax in liver
3) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.68 Pain Relevance 0
We analyzed the changes in neurological severity scores, infarct volume, number of apoptotic neurons, and the expression of G-CSF receptor, phosphorylated signal transducer and activator of transcription 3 (pSTAT3), cellular inhibitor of apoptosis protein 2 (cIAP2), Bcl-2, and Bax in the brain tissue.
Spec (analyzed) Regulation (changes) of Gene_expression (expression) of Bax in brain associated with apoptosis
4) Confidence 0.33 Published 2008 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 18832793 Disease Relevance 1.95 Pain Relevance 0.17
other techniques to determine the protein expressions of Bax, Bcl-2, and NF-?
Spec (determine) Regulation (determine) of Spec (determine) Gene_expression (expressions) of Bax
5) Confidence 0.31 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234334 Disease Relevance 0.62 Pain Relevance 0.12
No significant change in the expression of Bax and Bcl-2 proteins was observed with Os treatment as compared to control IR in the present study.
Neg (No) Regulation (change) of Gene_expression (expression) of Bax
6) Confidence 0.27 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1397864 Disease Relevance 0.55 Pain Relevance 0.07
Cell death after exposure to different NO-donors such as SNP has been to date established through the expression of tumor suppressor gene p53 and pro-apoptotic genes such as bax, cyclin-dependent kinase inhibitor p21, the inhibited expression of anti-apoptotic protein bcl-2, the inhibited NF-?
Regulation (through) of Gene_expression (expression) of bax associated with cancer, apoptosis and death
7) Confidence 0.26 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC516785 Disease Relevance 0.68 Pain Relevance 0
Expression of apoptosis-related molecules, such as Bcl-xS, Bax, and caspase-3, seems to be little regulated in the early stage of this vessel remodeling process.


Neg (little) Regulation (regulated) of Gene_expression (Expression) of Bax associated with apoptosis
8) Confidence 0.26 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC119850 Disease Relevance 0.74 Pain Relevance 0
The contribution of non-apoptotic mechanisms in the CA1 region after SE is also corroborated by our recent finding that the expression of Bax and caspase-3 proteins remained unchanged after SE in P21 rats [23].
Neg (unchanged) Regulation (unchanged) of Gene_expression (expression) of Bax associated with status epilepticus and apoptosis
9) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.88 Pain Relevance 0.06
Expressions of Bax and Bcl-2 at mRNA and protein levels were altered resulting in an increase in Bax : Bcl-2 ratio in apoptotic cells, which also exhibited overexpression of 80 kDa calpain and an increase in calpain-cleaved 145 kDa alpha-spectrin breakdown product.
Regulation (altered) of Gene_expression (Expressions) of Bax in apoptotic cells associated with apoptosis
10) Confidence 0.25 Published 2007 Journal Neurochem. Res. Section Abstract Doc Link 17570061 Disease Relevance 1.65 Pain Relevance 0.23
In liver, arsenic also markedly enhances cellular Bax and reduces Bcl-2 mRNA levels and therefore probably regulates Bax and Bcl-2 expression by both transcriptional and post-transcriptional levels.
Spec (probably) Regulation (regulates) of Gene_expression (expression) of Bax in liver
11) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.62 Pain Relevance 0

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