INT14470

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Context Info
Confidence 0.67
First Reported 1990
Last Reported 2011
Negated 4
Speculated 2
Reported most in Abstract
Documents 83
Total Number 87
Disease Relevance 110.55
Pain Relevance 4.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 7
nodules 3
shell 1
hepatocytes 1
margins 1
HCC (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 108 100.00 Very High Very High Very High
Bile 111 99.64 Very High Very High Very High
palliative 47 99.46 Very High Very High Very High
imagery 414 99.36 Very High Very High Very High
Pain 37 97.88 Very High Very High Very High
Inflammation 122 96.76 Very High Very High Very High
fibrosis 191 96.16 Very High Very High Very High
abdominal pain 11 91.80 High High
alcohol 47 89.68 High High
agonist 113 87.28 High High
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 2690 100.00 Very High Very High Very High
Cancer 1881 100.00 Very High Very High Very High
Carcinoma 1056 100.00 Very High Very High Very High
Familial Adenomatous Polyposis 728 100.00 Very High Very High Very High
Hepatitis C Virus Infection 562 100.00 Very High Very High Very High
Cirrhosis 527 100.00 Very High Very High Very High
Metastasis 434 100.00 Very High Very High Very High
Hepatitis B Virus Infection 136 100.00 Very High Very High Very High
Hepatitis 131 100.00 Very High Very High Very High
Cleidocranial Dysplasia 16 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Early detection of HCC is a key factor in improving outcomes of therapies.
Gene_expression (detection) of HCC associated with hepatocellular cancer
1) Confidence 0.67 Published 2002 Journal J Vasc Interv Radiol Section Abstract Doc Link 12354833 Disease Relevance 0.88 Pain Relevance 0.14
Fifty per cent of patients diagnosed with HCC present with metastatic disease.
Gene_expression (present) of HCC associated with hepatocellular cancer and metastasis
2) Confidence 0.59 Published 2008 Journal Am Surg Section Abstract Doc Link 18453303 Disease Relevance 1.60 Pain Relevance 0.09
The patient was previously diagnosed with unresectable HCC and had undergone six cycles of chemoembolization therapy.
Gene_expression (diagnosed) of HCC associated with hepatocellular cancer
3) Confidence 0.59 Published 2008 Journal Am Surg Section Abstract Doc Link 18453303 Disease Relevance 1.72 Pain Relevance 0.12
Finally, Gilsanz et al [15] reported a case of a patient who had a mass in the gluteal region for three years that turned out to be a metastasis of HCC.
Gene_expression (metastasis) of HCC associated with hepatocellular cancer and metastasis
4) Confidence 0.59 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC1187929 Disease Relevance 1.13 Pain Relevance 0.09
The review of the literature revealed a few reports of metastases being the initial presentation of HCC.
Gene_expression (presentation) of HCC associated with hepatocellular cancer and metastasis
5) Confidence 0.59 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC1187929 Disease Relevance 0.96 Pain Relevance 0.16
To our knowledge, this is the first case with adrenal metastasis as first presentation and subsequent histological confirmation of a silent HCC.
Gene_expression (presentation) of HCC associated with hepatocellular cancer and metastasis
6) Confidence 0.59 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC1187929 Disease Relevance 1.09 Pain Relevance 0.06
Spontaneous regression of hepatocellular carcinoma (HCC) is a rare phenomenon.
Gene_expression (regression) of HCC associated with hepatocellular cancer
7) Confidence 0.58 Published 2005 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 15740500 Disease Relevance 0.53 Pain Relevance 0.06
Historically, the prognosis for patients with HCC has been poor; however, improved surveillance and radiologic imaging techniques have led to earlier detection of HCC and an increased opportunity to treat patients.
Gene_expression (detection) of HCC associated with hepatocellular cancer and imagery
8) Confidence 0.58 Published 2004 Journal Clin J Oncol Nurs Section Abstract Doc Link 15354926 Disease Relevance 1.15 Pain Relevance 0.12
The spontaneous and durable regression of the HCC and the persistent peripheral enhancing rim could be explained by a strong and persistent activation of the immune system directed against the neoplastic cells.
Gene_expression (regression) of HCC in immune system
9) Confidence 0.58 Published 2009 Journal Dig Liver Dis Section Abstract Doc Link 18420472 Disease Relevance 0.44 Pain Relevance 0.20
This article discusses the recent innovative strategies to interfere with the progression of HCC, including novel gene therapy strategies.
Gene_expression (progression) of HCC associated with hepatocellular cancer
10) Confidence 0.58 Published 2002 Journal Expert Opin Biol Ther Section Abstract Doc Link 11849113 Disease Relevance 0.76 Pain Relevance 0.09
Locoregional therapies are useful as bridging therapy for patients awaiting liver transplantation and as palliative therapies in patient with unresectable HCC.
Gene_expression (unresectable) of HCC in liver associated with hepatocellular cancer and palliative
11) Confidence 0.58 Published 2009 Journal Minerva Med. Section Abstract Doc Link 19277004 Disease Relevance 1.38 Pain Relevance 0.10
A 61-year-old man with an unresectable HCC, which had been detected on spontaneous rupture, complained of a severe neck pain and numbness of both arms.
Gene_expression (detected) of HCC in arms associated with pain, hypesthesia, spontaneous rupture, neck pain and hepatocellular cancer
12) Confidence 0.53 Published 1990 Journal Gan No Rinsho Section Abstract Doc Link 1694902 Disease Relevance 1.48 Pain Relevance 0.26
In our patient, HCC with direct invasion to the diaphragm was seen and was resected with clear margins, and intrahepatic recurrence was controlled by local ablation.
Gene_expression (resected) of HCC in margins associated with hepatocellular cancer and recurrence
13) Confidence 0.53 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2491653 Disease Relevance 2.21 Pain Relevance 0.03
However, there are cases in which PEIT becomes difficult because the HCC could not be detected by ultrasonography or the tumor is located in an area where it is impossible to perform PEIT.
Neg (not) Gene_expression (detected) of HCC associated with cancer
14) Confidence 0.52 Published 2002 Journal Int. J. Oncol. Section Abstract Doc Link 11788887 Disease Relevance 0.47 Pain Relevance 0.05
Most HCC patients present with large and poorly differentiated tumors; they have a short survival time.
Gene_expression (present) of HCC associated with cancer and hepatocellular cancer
15) Confidence 0.47 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1617093 Disease Relevance 1.05 Pain Relevance 0.05
To investigate its role in hepatocarcinogenesis, we examined the expression of TRPV2 in human hepatocellular carcinoma (HCC) samples and analyzed the association of TRPV2 expression with its clinical significance.
Spec (examined) Gene_expression (expression) of HCC associated with hepatocellular cancer
16) Confidence 0.43 Published 2010 Journal Cancer Genet. Cytogenet. Section Abstract Doc Link 20113837 Disease Relevance 0.84 Pain Relevance 0.14
In this study, we first tested the sensitivity of Mcl-1 expressing HCC cells to a panel of chemotherapeutic drugs.
Gene_expression (expressing) of HCC associated with carcinoma
17) Confidence 0.37 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.89 Pain Relevance 0
However, since p53 mutations are frequently found in HCC, Mcl-1-Bak interaction might be more stable in HCC, resulting in a stabilization of mitochondria.
Gene_expression (found) of HCC associated with carcinoma
18) Confidence 0.37 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.75 Pain Relevance 0
TRPV2 expression in 55 HCC patients was examined by immunohistochemistry, and the correlation between TRPV2 levels and clinicopathologic parameters was analyzed.
Spec (examined) Gene_expression (expression) of HCC associated with hepatocellular cancer
19) Confidence 0.37 Published 2010 Journal Cancer Genet. Cytogenet. Section Abstract Doc Link 20113837 Disease Relevance 0.96 Pain Relevance 0.13
Local recurrence, response rates, and mortality from RFA rival surgical resection in HCC less than 3 cm.
Gene_expression (resection) of HCC
20) Confidence 0.34 Published 2010 Journal Cancer Control Section Body Doc Link 20404792 Disease Relevance 0.07 Pain Relevance 0

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