INT144700

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 12.28
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Kras) mitochondrion (Kras) plasma membrane (Kras)
GTPase activity (Kras)
Anatomy Link Frequency
L929 5
fibroblasts 2
cardiac myocytes 1
Kras (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 1 100.00 Very High Very High Very High
Glutamate receptor 1 94.52 High High
Neurotransmitter 2 81.84 Quite High
Inflammation 85 73.68 Quite High
cINOD 16 58.64 Quite High
ischemia 9 55.28 Quite High
fibrosis 8 54.32 Quite High
aspirin 6 54.24 Quite High
Limbic system 1 28.96 Quite Low
Opioid 1 20.96 Low Low
Disease Link Frequency Relevance Heat
Aging 134 99.96 Very High Very High Very High
Chromosomal Instability 15 99.44 Very High Very High Very High
Insulin Resistance 22 99.36 Very High Very High Very High
Sarcoma 1 99.24 Very High Very High Very High
Colon Cancer 64 98.96 Very High Very High Very High
Cleidocranial Dysplasia 10 97.74 Very High Very High Very High
Polyps 193 97.30 Very High Very High Very High
Familial Adenomatous Polyposis 256 97.20 Very High Very High Very High
Cancer 380 96.56 Very High Very High Very High
Skin Cancer 9 95.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genetic alterations such as the p16(INK4a) deletion, melanocortin 1 receptor (MC1R), RAS, and v-raf murine sarcoma viral oncogene homolog B1 (BRAF) may be indicative of a predisposition to melanoma development.
Gene_expression (deletion) of RAS associated with sarcoma, melanocortin 1 receptor and skin cancer
1) Confidence 0.41 Published 2007 Journal Mol. Carcinog. Section Abstract Doc Link 17570501 Disease Relevance 0.80 Pain Relevance 0.10
Relatively large numbers of guanine nucleotide-binding protein (G protein) isoforms and Ras subfamily of GTPases were identified; G(s)?
Gene_expression (subfamily) of Ras
2) Confidence 0.20 Published 2007 Journal Proteome Sci Section Body Doc Link PMC2045652 Disease Relevance 0.05 Pain Relevance 0.12
Several important genes have been characterised as being involved in the Chromosomal Instability pathway, namely the APC, k-ras, p53 genes and mutations in the TGF-?
Gene_expression (genes) of ras associated with chromosomal instability
3) Confidence 0.09 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.32 Pain Relevance 0
Several important genes have been characterised as being involved in the Chromosomal Instability pathway, namely the APC, k-ras, p53 genes and mutations in the TGF-?
Gene_expression (mutations) of ras associated with chromosomal instability
4) Confidence 0.09 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.33 Pain Relevance 0
In their model, it was suggested that mutation of the k-ras proto-oncogene leading to activation of the oncogene as well as mutational inactivation of tumour suppressor genes existing on chromosomes 5q (APC), 7p (p53) and 18q (SMAD4) were the key initiators of colorectal carcinogenesis.
Gene_expression (proto) of ras associated with cancer
5) Confidence 0.09 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.33 Pain Relevance 0
K-ras mutations
Gene_expression (mutations) of ras
6) Confidence 0.09 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.26 Pain Relevance 0
They also showed that 90% of serrated polyps that showed dysplasia had mutations in BRAF or k-ras and that these acquired mutations were mutually exclusive, i.e. either BRAF or k-ras was present.
Gene_expression (present) of ras associated with cleidocranial dysplasia and polyps
7) Confidence 0.08 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.70 Pain Relevance 0
Activation mutations in Ras result in the
Gene_expression (result) of Ras
8) Confidence 0.08 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.99 Pain Relevance 0.14
K-Ras mutation is found
Gene_expression (mutation) of Ras
9) Confidence 0.07 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 1.05 Pain Relevance 0.05
The immunoblot presented in Figure 5b shows that L929 cells expressing caRas exhibited higher degrees of Erk1/2 phosphorylation than control-transfected cells when grown in the absence of VPA (Figure 5b, lanes 2 and 1).
Gene_expression (expressing) of caRas in L929
10) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0
Cells expressing caRas did not move significantly faster than control-transfected cells when grown in the absence of VPA (Figure 5c).
Gene_expression (expressing) of caRas
11) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0
Figure 5a shows micrographs of L929 cells not expressing or expressing caRas and grown in the presence or absence of VPA.
Neg (not) Gene_expression (expressing) of caRas in L929
12) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0
These results demonstrate that exposure to VPA reversed the effects of caRas expression on L929 cell morphology and the degree of Erk1/2 phosphorylation.
Gene_expression (expression) of caRas in L929
13) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0
To determine whether VPA modulated the MAPK pathway upstream or downstream of Ras, the effects of VPA were investigated in L929 cells expressing constitutively active Ras (caRas).
Gene_expression (expressing) of caRas in L929
14) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0
However, VPA caused equally strong inhibition of Erk1/2 phosphorylation in control- and caRas-transfected cells (Figure 5b, lanes 3 and 4).
Gene_expression (transfected) of caRas
15) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0
Figure 5a shows micrographs of L929 cells not expressing or expressing caRas and grown in the presence or absence of VPA.
Neg (not) Gene_expression (expressing) of caRas in L929
16) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0
However, exposure of caRas-expressing cells to VPA caused them to adopt a phenotype similar to control-transfected cells treated with VPA (Figure 5a, two rightmost images).
Gene_expression (expressing) of caRas
17) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0
Control-transfected cells adopted a stellate phenotype with an increased area when treated with VPA (Figure 5a, two leftmost images), whereas caRas-expressing cells were more round and loosely attached (Figure 5a, two topmost images), a typical phenotype of Ras-transformed cells [22].
Gene_expression (expressing) of caRas
18) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0
Dyslipidemia and increased production of free oxygen radicals48,49 may cause metabolic alterations to the genetic transcription factors and coding.50,51 The result of these alterations is a modification in the translation of nucleoprotein genes, such as RAS and insulin-like growth factor 1 (IGF-1), responsible for the myocardial substrate and myocardial fiber structure and also for the maintenance of a normal myocardial compliance.52,53 Accordingly, increased expression of the early cardiopathology-related gene RAS predisposes to insulin resistance, whereas the IGF-1 increases myocardial contractility through an increase of the intracellular calcium accumulation and by intensifying the sensitivity of the cardiac myofibers to the circulatory calcium concentration. 54 IGF-1 is present in the cardiac myocytes, and its expression is augmented by decreased insulin concentration, increased mechanical stress, and increased peripheral vascular resistance.
Gene_expression (expression) of RAS in cardiac myocytes associated with stress and insulin resistance
19) Confidence 0.02 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2964943 Disease Relevance 0.96 Pain Relevance 0.08
Employing a more systematic approach, we compared the transcriptional profiles of aged murine stroma measured in this study (considering a false discovery rate of <25% and including those transcripts also found in leukocytes), with previously determined transcriptional profiles of human prostate fibroblasts induced to senesce by different means (H2O2, Bleomycin, replicative senescence, overexpression of p16 and overexpression of oncogenic RAS [11] and unpublished data).
Gene_expression (overexpression) of oncogenic RAS in fibroblasts associated with aging
20) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0.69 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox