INT144701

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Context Info
Confidence 0.75
First Reported 2006
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 8.42
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Cdkn2a) aging (Cdkn2a) DNA binding (Cdkn2a)
protein complex (Cdkn2a) cytoplasm (Cdkn2a) nucleolus (Cdkn2a)
Anatomy Link Frequency
lungs 1
Cdkn2a (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 61 99.92 Very High Very High Very High
Arthritis 108 98.40 Very High Very High Very High
tolerance 10 88.16 High High
rheumatoid arthritis 54 87.84 High High
cytokine 34 53.24 Quite High
Inflammation 59 52.84 Quite High
Inflammatory response 2 43.44 Quite Low
fibrosis 20 20.64 Low Low
metalloproteinase 11 18.80 Low Low
agonist 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 423 100.00 Very High Very High Very High
Aging 129 99.92 Very High Very High Very High
Melanoma 28 98.48 Very High Very High Very High
Arthritis 112 98.40 Very High Very High Very High
Targeted Disruption 92 98.16 Very High Very High Very High
Sarcoma 19 97.76 Very High Very High Very High
Apoptosis 122 96.76 Very High Very High Very High
Skin Cancer 154 95.16 Very High Very High Very High
Impaired Glucose Tolerance 14 88.80 High High
Rheumatoid Arthritis 54 87.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Melan-a cells are functionally Ink4a-Arf null, expressing neither p16INK4A nor ARF proteins (Sviderskaya et al., 2002).


Neg (neither) Gene_expression (expressing) of p16INK4A
1) Confidence 0.75 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0.15 Pain Relevance 0
Studying cells at different phases of transformation, we could show that an early event during transformation was the loss of expression of the CDKN2A locus, followed by inactivation of p53 and overexpression of c-myc.
Gene_expression (expression) of CDKN2A
2) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.58 Pain Relevance 0
Notably, hypermethylation of the CDKN2A promoter region has been shown to lead to loss of p16 expression in 19% of primary and 33% metastatic melanomas.[59] DNA methyltransferase(DNMT) inhibitors namely 5-azacytidine, 5-aza-20-deoxycytidine(decitabine), fazarabine, and dihydro-5-azacytidine have been extensively studied.
Gene_expression (expression) of p16 associated with melanoma
3) Confidence 0.58 Published 2010 Journal Journal of Carcinogenesis Section Body Doc Link PMC2862505 Disease Relevance 0.84 Pain Relevance 0
Sequencing of p16ink4a, k-ras and Rb cDNA
Gene_expression (cDNA) of p16ink4a
4) Confidence 0.58 Published 2006 Journal J Carcinog Section Body Doc Link PMC1559682 Disease Relevance 0.67 Pain Relevance 0
Two pathways are known to induce cell cycle arrest and senescence: the P16-Rb and P53-P21 pathways.
Gene_expression (pathways) of P16 associated with aging
5) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.87 Pain Relevance 0
Lack of p16 did not rescue the angiogenic defect of irradiated rings (data not shown), consistent with the absence of induction of P16 protein in irradiated HUVEC.
Neg (Lack) Gene_expression (Lack) of p16
6) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.14 Pain Relevance 0
This gene (also known as p15Ink4b) lies adjacent to the tumor suppressor gene CDKN2A and encodes a cyclin-dependent kinase.
Gene_expression (lies) of CDKN2A associated with cancer
7) Confidence 0.51 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2883590 Disease Relevance 0.54 Pain Relevance 0
Further, while expression of p19 was variably decreased in lungs from CCSPrtTA/tetO-Sox17 mice maintained on Dox for 2 days, no differences in the expression of p16 or p27 were observed after expression of Sox17 for 1–3 days (data not shown).
Gene_expression (expression) of p16 in lungs
8) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
Silencing of p19ARF, an upstream regulator of p53, facilitates reprogramming as well [105].
Gene_expression (Silencing) of p19ARF
9) Confidence 0.32 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.83 Pain Relevance 0
Genetic alterations such as the p16(INK4a) deletion, melanocortin 1 receptor (MC1R), RAS, and v-raf murine sarcoma viral oncogene homolog B1 (BRAF) may be indicative of a predisposition to melanoma development.
Gene_expression (deletion) of p16 associated with sarcoma, melanocortin 1 receptor and skin cancer
10) Confidence 0.28 Published 2007 Journal Mol. Carcinog. Section Abstract Doc Link 17570501 Disease Relevance 0.80 Pain Relevance 0.10
However, over-expression of Tert in the background of enhanced cancer resistance (enhanced expression of p53, p16 and p19ARF) increased lifespan in Sp53/Sp16/SArf/TgTert transgenic mice [50].
Gene_expression (expression) of p19ARF associated with targeted disruption, aging and cancer
11) Confidence 0.26 Published 2011 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC3001304 Disease Relevance 0.78 Pain Relevance 0.07
However, over-expression of Tert in the background of enhanced cancer resistance (enhanced expression of p53, p16 and p19ARF) increased lifespan in Sp53/Sp16/SArf/TgTert transgenic mice [50].
Gene_expression (expression) of p16 associated with targeted disruption, aging and cancer
12) Confidence 0.26 Published 2011 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC3001304 Disease Relevance 0.78 Pain Relevance 0.07
Melan-a cells are functionally Ink4a-Arf null, expressing neither p16INK4A nor ARF proteins (Sviderskaya et al., 2002).


Gene_expression (null) of Ink4a-Arf
13) Confidence 0.21 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0.15 Pain Relevance 0
It has been shown that HDACs inhibitors can selectively induce the expression of less than 10% of genes, some of which are involved in the inhibition of tumor growth (e.g., p21WAF1, p27Kip and p16ink4a) [19, 26, 38].
Gene_expression (expression) of p16ink4a associated with cancer
14) Confidence 0.14 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3004414 Disease Relevance 0.51 Pain Relevance 0
Other molecules that have been demonstrated to play a role in arthritis using gene transfer in various in vitro or animal models are Csk, cathepsin L, fibronectin, galectin-1, p16INK4A, p21Cip1, SOCS3, soluble CR1, superoxide dismutase and catalase, Ras, and prothymosin ?
Gene_expression (fibronectin) of p16INK4A associated with arthritis
15) Confidence 0.12 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2275302 Disease Relevance 0.78 Pain Relevance 0.29

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