INT144735

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 8
Total Number 15
Disease Relevance 3.21
Pain Relevance 5.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DDC) small molecule metabolic process (DDC) lyase activity (DDC)
cellular nitrogen compound metabolic process (DDC) cellular amino acid metabolic process (DDC) cytoplasm (DDC)
Anatomy Link Frequency
neurons 7
spinal 1
serotonergic neurons 1
brain 1
nucleus 1
DDC (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 621 100.00 Very High Very High Very High
dopamine receptor 21 100.00 Very High Very High Very High
antagonist 20 100.00 Very High Very High Very High
Spinal cord 352 99.56 Very High Very High Very High
Serotonin 132 99.08 Very High Very High Very High
Dorsal horn 40 99.00 Very High Very High Very High
Morphine 18 98.60 Very High Very High Very High
Central nervous system 17 98.52 Very High Very High Very High
monoamine 37 97.12 Very High Very High Very High
agonist 41 95.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 46 96.84 Very High Very High Very High
Small Cell Lung Cancer 63 96.60 Very High Very High Very High
Parkinsonian Disorders 8 95.60 Very High Very High Very High
Poisoning 80 93.40 High High
Parkinson's Disease 292 92.84 High High
Galactorrhea 124 84.20 Quite High
Depression 10 80.60 Quite High
Psychosis 17 78.44 Quite High
Anxiety Disorder 3 76.92 Quite High
Osteoporosis 1 73.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The transcription factor Pet1 is expressed in serotonergic neurons and directly activates the transcription of genes that are involved in the synthesis (Tph and Aadc) and uptake (Sert) of serotonin.
Gene_expression (synthesis) of Aadc in serotonergic neurons associated with serotonin
1) Confidence 0.75 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0.56
These neurons do not express tryptophan hydroxylase (Tph) or dopa decarboxylase (Aadc), which are required for serotonin synthesis, or the catabolic enzymes monoamine oxidase A and B.
Gene_expression (express) of dopa decarboxylase in neurons associated with serotonin and monoamine
2) Confidence 0.75 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.07 Pain Relevance 0.38
These neurons do not express tryptophan hydroxylase (Tph) or dopa decarboxylase (Aadc), which are required for serotonin synthesis, or the catabolic enzymes monoamine oxidase A and B.
Gene_expression (express) of Aadc in neurons associated with serotonin and monoamine
3) Confidence 0.75 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.07 Pain Relevance 0.38
Furthermore, the biochemical profile of these cells (presence of L-dopa decarboxylase, neuroendocrine markers, bombesin-like immunoreactivity, neuron-specific enolase and high concentrations of brain isoenzyme of creatine kinase) was found to be identical to human SCLC tumors observed in patients.
Gene_expression (presence) of dopa decarboxylase in brain associated with cancer and small cell lung cancer
4) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.75 Pain Relevance 0
However, it cannot be ruled out that these neurons express AADC but at levels too low to be detected by immunohistochemistry, especially since the levels of AADC expression seemed variable [81] and may vary according to the circadian rhythm.
Gene_expression (express) of AADC in neurons
5) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954154 Disease Relevance 0 Pain Relevance 0.40
Thus, L-DOPA synthesis in these neurons as a final releasable product raises questions about their functional significance.
Gene_expression (synthesis) of L-DOPA in neurons
6) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954154 Disease Relevance 0 Pain Relevance 0.37
However, it cannot be ruled out that these neurons express AADC but at levels too low to be detected by immunohistochemistry, especially since the levels of AADC expression seemed variable [81] and may vary according to the circadian rhythm.
Gene_expression (expression) of AADC in neurons
7) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954154 Disease Relevance 0 Pain Relevance 0.39
The phenotypic characterization of A11 neurons showed that, although they are TH-immunopositive, they do not express DBH or AADC.
Neg (not) Gene_expression (express) of AADC in neurons
8) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954154 Disease Relevance 0 Pain Relevance 0.28
However, this apparently more simple approach could be more risky as there is no inherent feedback mechanism in the control of AADC activity and increased concentrations of AADC could lead to dopamine over production.
Gene_expression (production) of AADC associated with dopamine
9) Confidence 0.39 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626922 Disease Relevance 0.05 Pain Relevance 0.43
Detailed immunohistochemical analysis suggested that these FG-labeled A11 neurons are tyrosine hydroxylase-positive but dopa-decarboxylase and dopamine transporter-negative, suggestive of a L-DOPAergic nucleus.
Neg (negative) Gene_expression (negative) of dopa-decarboxylase in nucleus associated with dopamine
10) Confidence 0.37 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2954154 Disease Relevance 0.46 Pain Relevance 0.46
In spinal cord, we also found a few AADC-positive neurons strictly located in the dorsal horn, within Rexed laminae I to VI (Fig. 7C–E).
Gene_expression (neurons) of AADC-positive in dorsal horn associated with dorsal horn and spinal cord
11) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954154 Disease Relevance 0 Pain Relevance 0.23
Double fluorescent labeling was performed to determine the distribution of TH- and AADC-positive neurons, TH- and Calbindin-D28k-(CALB, using anti-CALB antibody, 1?
Gene_expression (neurons) of AADC-positive in neurons
12) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954154 Disease Relevance 0 Pain Relevance 0
The diencephalic A11 area could be the major source of L-DOPA in the NHP spinal cord, where it may play a role in the modulation of sensorimotor integration through D2 and D3 receptors either directly or indirectly via dopamine formation in spinal dopa-decarboxylase-positives cells.



Gene_expression (source) of L-DOPA in spinal associated with dopamine and spinal cord
13) Confidence 0.33 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2954154 Disease Relevance 0.39 Pain Relevance 0.35
The treatment did not alter DOPA decarboxylase and dopamine beta-hydroxylase expression, demonstrating the specificity of morphine actions.
Gene_expression (expression) of DOPA decarboxylase associated with dopamine and morphine
14) Confidence 0.11 Published 2008 Journal Addict Biol Section Abstract Doc Link 17573783 Disease Relevance 0 Pain Relevance 0.49
A large group of medications can raise prolactin levels (Table 2 and Figure 2): drugs variably able of impairing central nervous system (CNS) dopaminergic function, such as false dopamine precursors, inhibitors of L-aromatic aminoacids decarboxylase and dopamine receptor antagonists, drugs enhancing serotoninergic neurotransmission, such as serotoninergic precursors, direct and indirect serotonin agonists and blockers of serotonin reuptake, histamine H2 receptor antagonists (Steiner et al 1976; Polleri et al 1980; Muller et al 1983; Di Renzo et al 1989; Molitch 2005).
Gene_expression (antagonists) of L-aromatic aminoacids decarboxylase in central nervous system associated with dopamine, antagonist, dopamine receptor, agonist, central nervous system and serotonin
15) Confidence 0.08 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 1.43 Pain Relevance 0.58

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