INT144738

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Context Info
Confidence 0.60
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 0
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CYP2D6) small molecule metabolic process (CYP2D6) oxidoreductase activity (CYP2D6)
endoplasmic reticulum (CYP2D6)
CYP2D6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 24 99.44 Very High Very High Very High
narcan 4 99.06 Very High Very High Very High
Dextromethorphan 120 95.28 Very High Very High Very High
antidepressant 4 86.80 High High
Dopamine 2 86.72 High High
opiate 2 55.68 Quite High
fluoxetine 4 21.96 Low Low
Disease Link Frequency Relevance Heat
Sprains And Strains 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endogenous morphine signaling via nitric oxide regulates the expression of CYP2D6 and COMT: autocrine/paracrine feedback inhibition.
Regulation (regulates) of Gene_expression (expression) of CYP2D6 associated with narcan and morphine
1) Confidence 0.60 Published 2008 Journal Addict Biol Section Title Doc Link 17573783 Disease Relevance 0 Pain Relevance 0.66
The analysis showed similar changes in the expression of CYP2D6 and COMT mRNA.
Regulation (changes) of Gene_expression (expression) of CYP2D6
2) Confidence 0.44 Published 2008 Journal Addict Biol Section Abstract Doc Link 17573783 Disease Relevance 0 Pain Relevance 0.69
CYP2D6 is a peripheral membrane-bound protein and is one of the most important CYPs in humans, being involved in the metabolism of about 30% of the currently marketed drugs, including ?
Regulation (peripheral) of Gene_expression (protein) of CYP2D6
3) Confidence 0.44 Published 2007 Journal J Biol Inorg Chem Section Body Doc Link PMC2099460 Disease Relevance 0 Pain Relevance 0.04
Moreover, the inability of the electrochemical approach to generate any amount of reduced enzyme in its active form, which is otherwise observed in dithionite-reduced protein samples, suggests that CYP2D6 inactivation is triggered by the application of potentials between ?
Regulation (triggered) of Gene_expression (inactivation) of CYP2D6
4) Confidence 0.44 Published 2007 Journal J Biol Inorg Chem Section Body Doc Link PMC2099460 Disease Relevance 0 Pain Relevance 0
4) regions of SERRS spectra of CYP2D6 on MUA-coated Ag electrodes at ?
Regulation (regions) of Gene_expression (spectra) of CYP2D6
5) Confidence 0.44 Published 2007 Journal J Biol Inorg Chem Section Body Doc Link PMC2099460 Disease Relevance 0 Pain Relevance 0.05
An additional but less pronounced feature observed in the SERRS spectrum of the CYP2D6–imidazole complex is the intensity decrease in the region around 1,630 cm?
Regulation (observed) of Gene_expression (spectrum) of CYP2D6
6) Confidence 0.44 Published 2007 Journal J Biol Inorg Chem Section Body Doc Link PMC2099460 Disease Relevance 0 Pain Relevance 0

General Comments

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