INT144755

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.09
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (INSR) endosome (INSR) plasma membrane (INSR)
nucleus (INSR) carbohydrate metabolic process (INSR)
Anatomy Link Frequency
blood 1
B cells 1
INSR (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 5 99.24 Very High Very High Very High
Central nervous system 4 98.24 Very High Very High Very High
Multiple sclerosis 65 97.72 Very High Very High Very High
rheumatoid arthritis 1 82.48 Quite High
Inflammation 8 81.80 Quite High
Chronic pancreatitis 2 50.00 Quite Low
tolerance 3 37.28 Quite Low
depression 4 32.64 Quite Low
headache 1 28.00 Quite Low
cytokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Weight Loss 4 100.00 Very High Very High Very High
Diabetes Mellitus 20 98.82 Very High Very High Very High
Multiple Sclerosis 69 97.72 Very High Very High Very High
Xerostomia 3 93.64 High High
Insulin Resistance 7 85.64 High High
Apoptosis 6 84.20 Quite High
Rheumatoid Arthritis 2 82.48 Quite High
INFLAMMATION 9 81.80 Quite High
Disorder Of Lipid Metabolism 17 73.68 Quite High
Overnutrition 39 70.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: The regulatory mechanisms of PP-mediated hepatic IR expression and combined IR and GLUT2 endocytosis after insulin binding are defective in chronic pancreatitis and contribute to the apancreatic diabetes, which characterizes this disease.


Negative_regulation (mechanisms) of IR
1) Confidence 0.41 Published 2007 Journal Pancreas Section Body Doc Link 17575539 Disease Relevance 0 Pain Relevance 0
There was a statistically significant greater weight loss in the IR-MPH (tid) (-2.1 ± 2.4 kg, p < 0.001) and the OROS-MPH groups (-2.8 ± 1.9 kg, p < 0.001) than in the placebo group(0.02 ± 1.7 kg); differences in weight loss between OROS-MPH and IR-MPH (tid) were small but statistically significant (p = 0.03).
Negative_regulation (loss) of IR-MPH associated with weight loss
2) Confidence 0.12 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2075491 Disease Relevance 0.36 Pain Relevance 0
Meta-analyses demonstrated that studies in patients with type 2 diabetes showed beneficial effects of low GI/GL diets reflected in decreased HbA1c, fructosamine(29,31) as well as HOMA-IR, fasting blood glucose and insulin levels(4).
Negative_regulation (decreased) of HOMA-IR in blood associated with diabetes mellitus
3) Confidence 0.02 Published 2010 Journal The British Journal of Nutrition Section Body Doc Link PMC2943747 Disease Relevance 0.38 Pain Relevance 0
Significant within-group reductions in HOMA-IR were found for the VLCHP, but no other groups (Table 4).
Negative_regulation (reductions) of HOMA-IR
4) Confidence 0.01 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2693519 Disease Relevance 0.54 Pain Relevance 0
The downregulation of insulin receptor tyrosine kinase substrate (BAIAP2L1) gene in B cells of MS siblings is significant.
Negative_regulation (downregulation) of insulin receptor in B cells associated with multiple sclerosis
5) Confidence 0.01 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 0.82 Pain Relevance 0.36

General Comments

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