INT144759

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.09
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (INSR) endosome (INSR) plasma membrane (INSR)
nucleus (INSR) carbohydrate metabolic process (INSR)
INSR (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 48 100.00 Very High Very High Very High
antagonist 14 92.24 High High
ischemia 26 86.88 High High
cytokine 12 84.24 Quite High
bradykinin 20 77.88 Quite High
agonist 10 71.36 Quite High
Chronic pancreatitis 2 50.00 Quite Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reperfusion Injury 64 100.00 Very High Very High Very High
INFLAMMATION 58 100.00 Very High Very High Very High
Targeted Disruption 20 100.00 Very High Very High Very High
Apoptosis 12 99.88 Very High Very High Very High
Cv Unclassified Under Development 24 86.88 High High
Death 12 79.92 Quite High
Pancreatitis 2 50.00 Quite Low
Injury 4 20.88 Low Low
Pressure And Volume Under Development 4 5.00 Very Low Very Low Very Low
Renal Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pro and anti-inflammatory molecule expression in B1R knockout or antagonism after renal IRI
Regulation (Pro) of Gene_expression (expression) of IRI associated with targeted disruption, reperfusion injury and inflammation
1) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.55 Pain Relevance 0.39
Pro and anti-inflammatory molecule expression in B1R knockout or antagonism after renal IRI
Regulation (antagonism) of Gene_expression (expression) of IRI associated with targeted disruption, reperfusion injury and inflammation
2) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.54 Pain Relevance 0.38
CONCLUSIONS: The regulatory mechanisms of PP-mediated hepatic IR expression and combined IR and GLUT2 endocytosis after insulin binding are defective in chronic pancreatitis and contribute to the apancreatic diabetes, which characterizes this disease.


Regulation (regulatory) of Gene_expression (expression) of IR
3) Confidence 0.26 Published 2007 Journal Pancreas Section Body Doc Link 17575539 Disease Relevance 0 Pain Relevance 0

General Comments

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