INT14477

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Context Info
Confidence 0.69
First Reported 1990
Last Reported 2007
Negated 2
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 5.88
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (TPSAB1) extracellular space (TPSAB1) extracellular region (TPSAB1)
Anatomy Link Frequency
plasma 1
erythrocyte 1
nasal 1
bladder 1
endothelium 1
TPSAB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 1 99.44 Very High Very High Very High
Angina 8 98.36 Very High Very High Very High
Inflammation 14 96.72 Very High Very High Very High
interstitial cystitis 3 96.04 Very High Very High Very High
cytokine 11 92.56 High High
Pain 4 82.76 Quite High
cva 3 75.32 Quite High
Opioid 1 70.88 Quite High
Inflammatory mediators 1 67.36 Quite High
Codeine 1 58.00 Quite High
Disease Link Frequency Relevance Heat
Adhesions 10 99.52 Very High Very High Very High
Anaphylaxis 213 99.32 Very High Very High Very High
Angina 8 98.36 Very High Very High Very High
Adverse Drug Reaction 2 97.88 Very High Very High Very High
Emergencies 16 97.84 Very High Very High Very High
Hypotension 28 97.32 Very High Very High Very High
INFLAMMATION 10 96.72 Very High Very High Very High
Interstitial Cystitis 3 96.04 Very High Very High Very High
Atherosclerosis 1 93.52 High High
Hyperoxaluria 2 93.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rechallenge of such sites with Ag during the sixth hour induced a peak release of histamine but no increase in tryptase levels.
Neg (no) Positive_regulation (increase) of tryptase
1) Confidence 0.69 Published 1990 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 1695232 Disease Relevance 0.16 Pain Relevance 0.06
A maximally elevated level of tryptase (25 micrograms/l) was detected at the first time point, 0.5 h, and elevated levels persisted to 6 h before a return to normal levels was documented at 24 h.
Positive_regulation (elevated) of tryptase
2) Confidence 0.69 Published 1991 Journal J. Immunol. Methods Section Abstract Doc Link 2019745 Disease Relevance 0.10 Pain Relevance 0.10
RESULTS: This is the first report that tryptase positive mast cells were not only increased (64-157 mast cells/mm(2)) in human endometriosis, but also highly activated (89%) in areas strongly stained positive for CRH/Ucn.
Positive_regulation (increased) of tryptase in mast cells
3) Confidence 0.48 Published 2004 Journal Am. J. Reprod. Immunol. Section Body Doc Link 15494048 Disease Relevance 0.35 Pain Relevance 0
[Tryptase levels are elevated during spontaneous ischemic episodes in unstable angina but not after the ergonovine test in variant angina].
Positive_regulation (elevated) of Tryptase associated with angina
4) Confidence 0.46 Published 1998 Journal Cardiologia Section Title Doc Link 9557375 Disease Relevance 0.84 Pain Relevance 0.62
This study was designed primarily to determine whether increased mast cell tryptase in the bladder wall may play a role in activating bladder endothelial cell phospholipase A(2) (PLA(2)), leading to increased inflammatory phospholipid metabolite accumulation, which may propagate the inflammatory process.
Positive_regulation (increased) of tryptase in bladder associated with inflammation
5) Confidence 0.41 Published 2005 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 15561975 Disease Relevance 0.45 Pain Relevance 0.27
Given the longer half-life of tryptase than histamine in plasma, measurements of plasma tryptase may become a useful diagnostic tool for identifying adverse reactions to anesthetics and RCM.
Positive_regulation (measurements) of tryptase in plasma associated with adverse drug reaction
6) Confidence 0.40 Published 1996 Journal Int. Arch. Allergy Immunol. Section Abstract Doc Link 8645973 Disease Relevance 0.17 Pain Relevance 0.07
In an emergency department study, elevated histamine levels were observed in 42 of 97 patients, but only 20 also exhibited increased tryptase levels [30].
Positive_regulation (increased) of tryptase associated with emergencies
7) Confidence 0.15 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2873621 Disease Relevance 1.02 Pain Relevance 0
However, tryptase levels may not be elevated in all forms of anaphylaxis (eg, it is frequently normal in foodassociated anaphylaxis) [18,30].
Neg (not) Positive_regulation (elevated) of tryptase associated with anaphylaxis
8) Confidence 0.15 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2873621 Disease Relevance 1.36 Pain Relevance 0
Furthermore, increased levels of eosinophil cationic protein (ECP) and albumin, but not tryptase, in nasal lavage from workers exposed to UV coatings have been observed.
Positive_regulation (increased) of tryptase in nasal
9) Confidence 0.08 Published 2001 Journal Acta Otolaryngol. Section Abstract Doc Link 11678174 Disease Relevance 0.21 Pain Relevance 0.13
Additional studies were undertaken to examine if fibronectin, a ligand for activated alpha 4 beta 1, was involved in PDBu-induced sickle erythrocyte adherence.
Positive_regulation (activated) of alpha 4 beta 1 in erythrocyte
10) Confidence 0.01 Published 1996 Journal Blood Section Abstract Doc Link 8943872 Disease Relevance 0.58 Pain Relevance 0.08
To elucidate other roles for alpha 4 beta 1 in sickle-cell adherence, the ability of activated alpha 4 beta 1 to promote adhesion to endothelium via a ligand different than VCAM-1 was explored.
Positive_regulation (activated) of alpha 4 beta 1 in endothelium associated with adhesions
11) Confidence 0.00 Published 1996 Journal Blood Section Abstract Doc Link 8943872 Disease Relevance 0.62 Pain Relevance 0.13

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