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Context Info
Confidence 0.53
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.24
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Hcn2) plasma membrane (Hcn2) transmembrane transport (Hcn2)
Anatomy Link Frequency
neurons 1
Hcn2 (Mus musculus)
Pain Link Frequency Relevance Heat
hCN2 7 100.00 Very High Very High Very High
Clonidine 1 98.72 Very High Very High Very High
Catecholamine 2 95.80 Very High Very High Very High
HCN1 2 95.60 Very High Very High Very High
analgesia 1 92.06 High High
noradrenaline 2 88.04 High High
Angina 1 60.00 Quite High
Disease Link Frequency Relevance Heat
Sleep Disorders 1 91.78 High High
Pressure Volume 2 Under Development 1 91.58 High High
Cv General 3 Under Development 1 60.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutation of Ala425 and Ile432 also attenuated the block of HCN2 by the more potent blocker cilobradine.
Negative_regulation (block) of HCN2 associated with hcn2
1) Confidence 0.53 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17578902 Disease Relevance 0.06 Pain Relevance 0.40
Studies with gene-targeted mice carrying deletions in the genes encoding alpha2A-, alpha2B- or alpha2C-adrenoceptors have provided new insight into adrenergic receptor biology: (1) In principle, all three alpha2-receptor subtypes may operate as presynaptic inhibitory feedback receptors to control the release of noradrenaline and adrenaline or other transmitters from neurons. (2) Pharmacological effects of non-selective alpha2-ligands could be assigned to specific receptor subtypes, e.g. hypotension, sedation and analgesia are mediated via alpha2A-receptors. (3) Alpha2-adrenoceptor deficient mice have helped to uncover novel and unexpected functions of these receptor, e.g. feedback control of catecholamine release via alpha2C-receptors in adrenal chromaffin cells and control of angiogenesis during embryonic development. (4) Additional pharmacological targets for alpha2-adrenoceptor ligands were identified, e.g. inhibition of cardiac HCN2 and HCN4 pacemaker channels by clonidine.
Negative_regulation (inhibition) of HCN2 in neurons associated with pressure volume 2 under development, catecholamine, noradrenaline, sleep disorders, clonidine, hcn2 and analgesia
2) Confidence 0.51 Published 2007 Journal Neurochem. Int. Section Abstract Doc Link 17664025 Disease Relevance 0.18 Pain Relevance 0.40

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