INT144792

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.74
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos1) mitochondrion (Nos1) oxidoreductase activity (Nos1)
plasma membrane (Nos1) cytoskeleton (Nos1) nucleus (Nos1)
Anatomy Link Frequency
spinal cord 2
body 2
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 18 99.40 Very High Very High Very High
Morphine 9 99.18 Very High Very High Very High
Spinal cord 57 98.88 Very High Very High Very High
addiction 2 98.28 Very High Very High Very High
Sciatic nerve 77 97.28 Very High Very High Very High
Physical dependence 1 91.68 High High
Neuropathic pain 22 88.28 High High
narcan 1 78.04 Quite High
IPN 2 74.48 Quite High
Pain 7 70.08 Quite High
Disease Link Frequency Relevance Heat
Body Weight 1 98.44 Very High Very High Very High
Drug Dependence 1 91.68 High High
Neuropathic Pain 55 88.28 High High
Ocular Toxicity (including Many Sub-types) 1 83.68 Quite High
Sneezing 1 83.24 Quite High
Syndrome 2 80.72 Quite High
Nervous System Injury 32 77.84 Quite High
Targeted Disruption 98 76.88 Quite High
Morphine Dependence 1 76.24 Quite High
Inflammatory Pain 2 74.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results obtained were as follows: (1) Sinomenine restored the decrease in body weight and alleviated the signs of morphine-withdrawal in mice. (2) Sinomenine also reduced the increases in nNOS mRNA expression and nNOS activity resulting from morphine-dependence, and simultaneously attenuated the high level of NO in both tissues following morphine-withdrawal. (3) Administration of sinomenine alone did not develop physical dependence in mice.
Negative_regulation (reduced) of Transcription (expression) of nNOS in body associated with addiction, body weight, physical dependence, withdrawal and morphine
1) Confidence 0.43 Published 2007 Journal Sheng Li Xue Bao Section Abstract Doc Link 17579782 Disease Relevance 0.59 Pain Relevance 1.33
Therefore, our subsequent aim is to evaluate the mRNA and protein expression of NOS1 and NOS2 isoenzymes in the spinal cord of WT mice at 21 days after sciatic nerve ligation and correlate it with their corresponding behavior responses.
Negative_regulation (evaluate) of Transcription (expression) of NOS1 in spinal cord associated with sciatic nerve and spinal cord
2) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.15 Pain Relevance 0.93

General Comments

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