INT1448

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Context Info
Confidence 0.48
First Reported 1977
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 23
Total Number 23
Disease Relevance 1.41
Pain Relevance 8.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Adra1a) plasma membrane (Adra1a) cellular_component (Adra1a)
response to stress (Adra1a) signal transducer activity (Adra1a)
Anatomy Link Frequency
muscle 2
cerebral cortex 2
mesenteric artery 2
smooth muscle cells 2
plasma 1
Adra1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 69 100.00 Very High Very High Very High
antagonist 28 100.00 Very High Very High Very High
Potency 5 100.00 Very High Very High Very High
monoamine 4 100.00 Very High Very High Very High
Dopamine 4 99.56 Very High Very High Very High
cerebral cortex 9 99.44 Very High Very High Very High
Clonidine 39 98.68 Very High Very High Very High
Opioid 1 98.32 Very High Very High Very High
Serotonin 2 96.40 Very High Very High Very High
vagus nerve 6 96.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Reprotox - General 1 1 100.00 Very High Very High Very High
Hypotension 2 96.08 Very High Very High Very High
Schizophrenia 1 90.52 High High
Attention Deficit Hyperactivity Disorder 1 88.32 High High
Sprains And Strains 4 87.88 High High
Aggression 1 84.88 Quite High
Depression 3 81.92 Quite High
Hypertension 2 75.00 Quite High
Depressive Disorder 1 67.48 Quite High
Headache 2 62.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration to rats of dietary lithium for 30 days was followed by evaluation of alpha-1 adrenergic receptor binding and of adrenergic-stimulated cyclic AMP (cAMP) accumulation in rat cerebral cortex.
alpha-1 adrenergic receptor Binding (binding) of in cerebral cortex associated with cerebral cortex
1) Confidence 0.48 Published 1990 Journal J. Neural Transm. Gen. Sect. Section Abstract Doc Link 1979002 Disease Relevance 0 Pain Relevance 0.20
Alpha-1 adrenergic receptor binding and adrenergic-stimulated cyclic AMP production in rat cerebral cortex after chronic lithium treatment.
Alpha-1 adrenergic receptor Binding (binding) of in cerebral cortex associated with cerebral cortex
2) Confidence 0.48 Published 1990 Journal J. Neural Transm. Gen. Sect. Section Title Doc Link 1979002 Disease Relevance 0 Pain Relevance 0.21
The binding of the antagonist IBE 2254 (IBE) to alpha 1-adrenergic receptors was characterized on intact DDT1 smooth muscle cells.
alpha 1-adrenergic Binding (binding) of in smooth muscle cells associated with antagonist
3) Confidence 0.48 Published 1984 Journal J. Recept. Res. Section Abstract Doc Link 6098670 Disease Relevance 0 Pain Relevance 0.17
Clonidine and tizanidine did not contract the rabbit iris dilator but shifted the curve for norepinephrine in a parallel manner, suggesting that they interact with the alpha 1B-subtype and act as competitive antagonists in this muscle.
alpha 1B-subtype Binding (interact) of in muscle associated with antagonist and clonidine
4) Confidence 0.48 Published 1992 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1331586 Disease Relevance 0 Pain Relevance 0.22
The order of inhibitory potency was similar to that for their alpha1A-adrenoceptor binding site affinity.
alpha1A-adrenoceptor Binding (affinity) of associated with potency
5) Confidence 0.44 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9527505 Disease Relevance 0 Pain Relevance 0.26
It is therefore concluded that in rat mesenteric artery, there are two distinct sites of interaction for the antagonists, prazosin and yohimbine, but the alpha-adrenoceptor agonists interact nonselectively with a single site in such a way that they are capable of affecting binding of either antagonist.
alpha-adrenoceptor Binding (interact) of in mesenteric artery associated with antagonist and agonist
6) Confidence 0.44 Published 1985 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2414598 Disease Relevance 0 Pain Relevance 0.77
In phenoxybenzamine-pretreated preparations, Sgd 101/75 (400 microM) did not antagonise NA (maximal effect and EC50 values not changed significantly), so it was concluded that Sgd 101/75 and NA interact with different alpha 1-adrenoceptor subtypes in this tissue.
alpha 1-adrenoceptor Binding (interact) of
7) Confidence 0.43 Published 1983 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 6142147 Disease Relevance 0 Pain Relevance 0.28
Methoxamine (up to 10(-3) M) had no effect on the contractile response to norepinephrine, suggesting that methoxamine does not interact with the alpha 1B-subtype.
alpha 1B-subtype Neg (not) Binding (interact) of
8) Confidence 0.42 Published 1992 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1331586 Disease Relevance 0 Pain Relevance 0.20
Characterization of IBE 2254 binding to alpha 1-adrenergic receptors on intact DDT1 smooth muscle cells: comparison with membrane binding and correlation with phosphoinositides breakdown.
alpha 1-adrenergic Binding (binding) of in smooth muscle cells
9) Confidence 0.37 Published 1984 Journal J. Recept. Res. Section Title Doc Link 6098670 Disease Relevance 0 Pain Relevance 0.25
In the equations the pharmacokinetics together with the actual engagement of the central alpha-adrenoceptor are accounted for.
alpha-adrenoceptor Binding (engagement) of
10) Confidence 0.36 Published 1977 Journal J. Med. Chem. Section Abstract Doc Link 201756 Disease Relevance 0.18 Pain Relevance 0.23
Alpha 1-adrenoceptor occupancy at a half-maximum response to each agonist was greater in SHR.
Alpha 1-adrenoceptor Binding (occupancy) of associated with agonist
11) Confidence 0.35 Published 1989 Journal J. Hypertens. Section Abstract Doc Link 2575115 Disease Relevance 0.47 Pain Relevance 0.51
Characterization of alpha1-adrenoceptor subtypes in facilitation of rat spinal motoneuron activity.
alpha1-adrenoceptor Binding (Characterization) of in spinal
12) Confidence 0.34 Published 1997 Journal Eur. J. Pharmacol. Section Title Doc Link 9527505 Disease Relevance 0 Pain Relevance 0.45
Agonists interaction with radiolabeled alpha-adrenoceptor antagonists binding sites in rat mesenteric artery.
alpha-adrenoceptor Binding (interaction) of in mesenteric artery associated with antagonist and agonist
13) Confidence 0.34 Published 1985 Journal J. Cardiovasc. Pharmacol. Section Title Doc Link 2414598 Disease Relevance 0 Pain Relevance 0.56
In contrast to their affinity at serotonergic (5-HT) and dopaminergic receptor subtypes, only limited information is available concerning their interaction with alpha-adrenoceptor subtypes.
alpha-adrenoceptor Binding (interaction) of
14) Confidence 0.33 Published 2008 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 18066532 Disease Relevance 0.12 Pain Relevance 0.21
Studies with 3H-WB 4101 in rat cerebral cortex indicated that this ligand bound to an alpha 1-adrenoceptor which was independent of the 3H-clonidine-binding site. 3H-Prazosin was a ligand for alpha 1-adrenoceptors in guinea pig brain and also in membranes from seminal vesicle.
alpha 1-adrenoceptor Binding (bound) of in seminal vesicle associated with cerebral cortex and clonidine
15) Confidence 0.33 Published 1980 Journal Circ. Res. Section Abstract Doc Link 6247087 Disease Relevance 0 Pain Relevance 0.60
Interaction of imidazolines with alkylation-sensitive and -resistant alpha-1 adrenoceptor subtypes.
alpha-1 adrenoceptor Binding (Interaction) of
16) Confidence 0.30 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 1677036 Disease Relevance 0 Pain Relevance 0.23
The NPY-alpha-1 interaction in stimulating plasma OT was not mediated by direct binding of the peptides to alpha-1-adrenergic receptor sites.
alpha-1-adrenergic Binding (binding) of in plasma
17) Confidence 0.29 Published 1993 Journal Endocrinology Section Abstract Doc Link 8381069 Disease Relevance 0 Pain Relevance 0.30
YM060, YM114, granisetron and ondansetron showed low affinities for 5-HT1A, 5-HT2 receptor, adrenergic alpha 1, alpha 2, dopamine D2, muscarinic M2, mu-opioid, benzodiazepine and histamine H1 receptors.
adrenergic alpha 1 Binding (affinities) of associated with dopamine and opioid
18) Confidence 0.29 Published 1995 Journal Neuropharmacology Section Abstract Doc Link 7566499 Disease Relevance 0.08 Pain Relevance 0.68
The interaction of imidazolines with alpha-1 adrenoceptor subtypes sensitive and resistant to inactivation by SZL-49 and chlorethylclonidine (CEC) has been evaluated.
alpha-1 adrenoceptor Binding (interaction) of
19) Confidence 0.24 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1677036 Disease Relevance 0 Pain Relevance 0.14
Thus, alpha2-adrenoceptor/imidazoline ligands (whether agonists and antagonists) induce paradoxical relaxation of small mesenteric or gracilis muscle arteries of rats, which are not affected by NO-synthase or cyclooxygenase inhibition, and appear related to direct non specific interactions of the alpha2-imidazoline ligands with alpha1-adrenergic receptors in vascular smooth muscle.
alpha1-adrenergic Binding (interactions) of in muscle associated with antagonist and agonist
20) Confidence 0.16 Published 2002 Journal Fundam Clin Pharmacol Section Abstract Doc Link 12570016 Disease Relevance 0 Pain Relevance 0.58

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