INT144822

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Context Info
Confidence 0.56
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 21
Disease Relevance 4.48
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CD14) extracellular region (CD14) plasma membrane (CD14)
Anatomy Link Frequency
monocytes 13
NK cells 5
T cells 3
macrophages 2
phagocytes 2
CD14 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 17 99.98 Very High Very High Very High
spinal inflammation 31 98.56 Very High Very High Very High
opioid receptor 4 98.52 Very High Very High Very High
Inflammation 267 98.04 Very High Very High Very High
anesthesia 85 97.80 Very High Very High Very High
rheumatoid arthritis 176 95.24 Very High Very High Very High
chemokine 60 84.56 Quite High
headache 2 81.80 Quite High
cytokine 59 76.96 Quite High
Arthritis 104 74.64 Quite High
Disease Link Frequency Relevance Heat
Low Back Pain 31 98.56 Very High Very High Very High
INFLAMMATION 280 98.04 Very High Very High Very High
Disease 68 95.64 Very High Very High Very High
Rheumatoid Arthritis 195 95.24 Very High Very High Very High
Death 21 92.24 High High
Obesity 3 90.24 High High
Hypersensitivity 17 86.96 High High
Cough 3 83.36 Quite High
Muscular Dystrophy 40 83.32 Quite High
Syndrome 14 82.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine inhibits AP-1 activity and CD14 expression in leukocytes by a nitric oxide and opioid receptor-dependent mechanism.
Negative_regulation (inhibits) of Gene_expression (expression) of CD14 in leukocytes associated with opioid receptor and morphine
1) Confidence 0.56 Published 2007 Journal Eur J Anaesthesiol Section Title Doc Link 17583593 Disease Relevance 0 Pain Relevance 0.24
CD14 expression on neutrophils was reduced after morphine treatment.
Negative_regulation (reduced) of Gene_expression (expression) of CD14 in neutrophils
2) Confidence 0.56 Published 2007 Journal Eur J Anaesthesiol Section Body Doc Link 17583593 Disease Relevance 0 Pain Relevance 0
The decrease in CD14 expression caused by morphine may play a role in inhibition of activator protein 1 activation following lipopolysaccharide treatment of phagocytes.


Negative_regulation (decrease) of Gene_expression (expression) of CD14 in phagocytes
3) Confidence 0.56 Published 2007 Journal Eur J Anaesthesiol Section Body Doc Link 17583593 Disease Relevance 0 Pain Relevance 0
The PBMCs were labeled with CD3, CD14, CD19 and CD56 microbeads for depletion of T cells, B cells, NK cells and monocytes according to manufactures description (Miltenyi Biotec, Germany).
Negative_regulation (depletion) of Gene_expression (microbeads) of CD14 in NK cells
4) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.20 Pain Relevance 0
Interestingly CD14+ macrophages are likely to represent a recently recruited immature subpopulation of macrophages in the synovial sublining, losing CD14 expression upon maturity [3].
Negative_regulation (losing) of Gene_expression (expression) of CD14 in macrophages
5) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.43 Pain Relevance 0.32
We then investigated whether the plasma of AAS patients could suppress the expression of HLA-DR on CD14HIGH and CD14LOW monocyte subpopulations of healthy donors.
Negative_regulation (suppress) of Gene_expression (expression) of CD14LOW in monocyte
6) Confidence 0.31 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.14
The increase in cortisol levels observed in patients undergoing vascular surgery (both AAS and CAS) was negatively correlated with HLA-DR expression on both CD14HIGH and CD14LOW monocytes.
Negative_regulation (correlated) of Gene_expression (expression) of CD14HIGH in monocytes
7) Confidence 0.31 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0
It can be seen that HLA-DR expression on CD14HIGH and CD14LOW monocytes at POD1 was decreased as shown by a leftward shift as compared to levels at T1.
Negative_regulation (decreased) of Gene_expression (expression) of CD14HIGH in monocytes associated with anesthesia
8) Confidence 0.31 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.11 Pain Relevance 0.56
The increase in cortisol levels observed in patients undergoing vascular surgery (both AAS and CAS) was negatively correlated with HLA-DR expression on both CD14HIGH and CD14LOW monocytes.
Negative_regulation (correlated) of Gene_expression (expression) of CD14LOW in monocytes
9) Confidence 0.31 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0
We then investigated whether the plasma of AAS patients could suppress the expression of HLA-DR on CD14HIGH and CD14LOW monocyte subpopulations of healthy donors.
Negative_regulation (suppress) of Gene_expression (expression) of CD14HIGH in monocyte
10) Confidence 0.31 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.14
Conventional RT-PCR at 30 cycles revealed marked higher expression of HLA-DRA, LYZ, and CD14 transcripts in eEPCs, while CAV1, VE-cadherin, and vWF transcripts were only present in OECs (Figure 3A).
Negative_regulation (revealed) of Gene_expression (expression) of CD14
11) Confidence 0.30 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2881111 Disease Relevance 0.07 Pain Relevance 0.04
Low levels of CD14 were detected in most cultures but tended to decrease during passaging.


Negative_regulation (decrease) of Gene_expression (levels) of CD14
12) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875643 Disease Relevance 0.21 Pain Relevance 0.11
Expression of CD14 and CD163 was decreased by enzyme exposure but not further decreased by rotation (Figure 3b).
Negative_regulation (decreased) of Gene_expression (Expression) of CD14
13) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875643 Disease Relevance 0.17 Pain Relevance 0
Expression of CD14 and CD163 was decreased by enzyme exposure but not further decreased by rotation (Figure 3b).
Neg (not) Negative_regulation (decreased) of Gene_expression (Expression) of CD14
14) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875643 Disease Relevance 0.18 Pain Relevance 0
The expression of CD14, TLR4 and TLR2 was then reduced on fresh CD4+CD28null T cells from AS patients treated with TNF-?
Negative_regulation (reduced) of Gene_expression (expression) of CD14 in T cells associated with spinal inflammation
15) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.85 Pain Relevance 0.56
mg/d resulted in a 36.2% reduction in TLR4 expression on CD14+ monocytes.
Negative_regulation (reduction) of Gene_expression (expression) of CD14 in monocytes
16) Confidence 0.15 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.32 Pain Relevance 0.28
The PBMCs were labeled with CD3, CD14, CD19 and CD56 microbeads for depletion of T cells, B cells, NK cells and monocytes according to manufactures description (Miltenyi Biotec, Germany).
Negative_regulation (depletion) of in monocytes Gene_expression (microbeads) of CD14 in NK cells
17) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.20 Pain Relevance 0
The PBMCs were labeled with CD3, CD14, CD19 and CD56 microbeads for depletion of T cells, B cells, NK cells and monocytes according to manufactures description (Miltenyi Biotec, Germany).
Negative_regulation (depletion) of in T cells Gene_expression (microbeads) of CD14 in NK cells
18) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.20 Pain Relevance 0
The PBMCs were labeled with CD3, CD14, CD19 and CD56 microbeads for depletion of T cells, B cells, NK cells and monocytes according to manufactures description (Miltenyi Biotec, Germany).
Negative_regulation (depletion) of in B cells Gene_expression (microbeads) of CD14 in NK cells
19) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.20 Pain Relevance 0
We found both CD14+ and CD16+ monocytes significantly reduced after storage (the latter, thought to represent inflammatory monocytes [9] in humans were more markedly affected).
Negative_regulation (reduced) of Gene_expression (monocytes) of CD14 in inflammatory monocytes associated with inflammation
20) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2872666 Disease Relevance 0.94 Pain Relevance 0.13

General Comments

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