INT144828

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Context Info
Confidence 0.47
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 7.84
Pain Relevance 3.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx7) cell morphogenesis (P2rx7) mitochondrion organization (P2rx7)
protein complex (P2rx7) transmembrane transport (P2rx7) cytoplasm (P2rx7)
Anatomy Link Frequency
microglia 2
pore 1
astrocytes 1
epithelial cells 1
P2rx7 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 435 99.08 Very High Very High Very High
Inflammation 493 98.08 Very High Very High Very High
Inflammatory stimuli 20 98.08 Very High Very High Very High
Inflammatory response 59 98.00 Very High Very High Very High
antagonist 113 97.50 Very High Very High Very High
agonist 92 97.18 Very High Very High Very High
Pain 87 94.96 High High
Arthritis 31 93.96 High High
rheumatoid arthritis 41 84.00 Quite High
ischemia 14 79.96 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 67 99.04 Very High Very High Very High
INFLAMMATION 610 98.08 Very High Very High Very High
Nociception 5 98.08 Very High Very High Very High
Apoptosis 113 97.68 Very High Very High Very High
Hypertension 2 95.96 Very High Very High Very High
Disease 138 95.76 Very High Very High Very High
Amyloid Plaque 4 95.08 Very High Very High Very High
Pain 87 94.96 High High
Arthritis 38 93.96 High High
Mycobacterial Infection 34 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that the P2X7R can be associated with two different pathways, inducing pseudoapoptosis or apoptosis in epithelial cells.
P2X7R Binding (associated) of in epithelial cells associated with apoptosis
1) Confidence 0.47 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.65 Pain Relevance 0.05
gene expression over the time course), indicative of a synergy between P2X7, IL-1?
P2X7 Binding (synergy) of
2) Confidence 0.37 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.25 Pain Relevance 0.20
animals across the whole timecourse, indicating that the effect of P2X7 receptor ligation on down-regulation of cytokine levels local to insult may be quite selective (Table 1).
P2X7 receptor Binding (ligation) of associated with cytokine
3) Confidence 0.37 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.08 Pain Relevance 0.29
A more extensive range of potent, selective P2X7R ligands is required for a better understanding of the cascade of cellular processes associated with the P2X7R.
P2X7R Binding (associated) of
4) Confidence 0.35 Published 2007 Journal Curr. Med. Chem. Section Abstract Doc Link 17584060 Disease Relevance 0.36 Pain Relevance 0.44
Only when selective agonists and antagonists are widely available can any such assertions be addressed, although it is important to consider them as part of the broader recognition of the P2X7R as a potential therapeutic target.
P2X7R Binding (recognition) of associated with antagonist and agonist
5) Confidence 0.35 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.93 Pain Relevance 0.36
As such, drugs that block P2X7 directly, or interact with proteins that modulate P2X7 activity, may have the potential to treat a broad range of inflammatory diseases, including pain associated with inflammation.


P2X7 Binding (interact) of associated with pain, inflammation and disease
6) Confidence 0.35 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 1.02 Pain Relevance 0.54
Because P2X7R-induced panx1-dependent dye uptake is calcium-independent, CBX-sensitive, and associated with IL-1?
P2X7R-induced Binding (associated) of
7) Confidence 0.34 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0
Taken together, it seems most likely that K+ efflux occurs through the P2X7R ion channel itself and that panx1 acts on the inflammasome downstream of ion flux.
P2X7R Binding (occurs) of
8) Confidence 0.34 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0
release

The P2X7 receptor (P2X7R) is uniquely associated with two distinct cellular responses: activation of a dye-permeable pathway allowing passage of molecules up to 900 Da and rapid release of the pro-inflammatory cytokine, interleukin-1?

P2X7R Binding (associated) of associated with inflammation and cytokine
9) Confidence 0.33 Published 2009 Journal Purinergic Signal Section Title Doc Link PMC2686830 Disease Relevance 0.09 Pain Relevance 0.09
release

The P2X7 receptor (P2X7R) is uniquely associated with two distinct cellular responses: activation of a dye-permeable pathway allowing passage of molecules up to 900 Da and rapid release of the pro-inflammatory cytokine, interleukin-1?

P2X7 receptor Binding (associated) of associated with inflammation and cytokine
10) Confidence 0.33 Published 2009 Journal Purinergic Signal Section Title Doc Link PMC2686830 Disease Relevance 0.09 Pain Relevance 0.09
Blood samples from individuals with a reduced capacity for monocyte P2X7 ‘large pore–formation produced lower levels of TNF-?
P2X7 Binding (capacity) of in pore
11) Confidence 0.32 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.15 Pain Relevance 0.20
This correlates with the observation that the P2X7 ????
P2X7 Binding (???) of
12) Confidence 0.32 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.52 Pain Relevance 0.26
In addition, NLRP3 can be activated by signals that induce potassium efflux, such as ATP, via the P2X7 receptor, or by toxins such as nigericin.
P2X7 Binding (receptor) of
13) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888190 Disease Relevance 0.33 Pain Relevance 0.03
Our data demonstrate that although LPS activation has a minor impact on P2X7 receptors that remain the major ionotropic ATP receptors in microglia, it specifically enhances responses to low ATP concentrations mediated by P2X4 receptors, highlighting the significant contribution of both subtypes to neuroinflammatory mechanisms and pathologies.
P2X7 Binding (impact) of in microglia
14) Confidence 0.23 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17675190 Disease Relevance 0.23 Pain Relevance 0.16
Therefore, the protection afforded by deletion of the P2X7 receptor is consistent with the knockout mice possessing a diminished capacity to generate mature IL-1?.
P2X7 receptor Binding (deletion) of associated with targeted disruption
15) Confidence 0.17 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0.99 Pain Relevance 0.31
Signaling pathways associated with P2X7 receptor activation Mechanistic elements engaged as a result of P2X7 receptor activation that are responsible for initiating IL-1?
P2X7 receptor Binding (associated) of
16) Confidence 0.17 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0
Ligation of the P2X7 receptor leads to rapid activation of caspase-1 and, like mature IL-1?
P2X7 receptor Binding (Ligation) of
17) Confidence 0.16 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0
P2X7 receptor overexpression is also associated with microglial cells in other pathological models; e.g., P2X7 receptor immunoreactivity appears to be upregulated around amyloid plaques in activated microglia and astrocytes in the Tg2576 transgenic mice having mutant amyloid precursor protein (APP) [71].
P2X7 receptor Binding (associated) of in astrocytes associated with targeted disruption, alzheimer's dementia and amyloid plaque
18) Confidence 0.13 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096753 Disease Relevance 1.07 Pain Relevance 0.07
P2X7 receptor overexpression is also associated with microglial cells in other pathological models; e.g., P2X7 receptor immunoreactivity appears to be upregulated around amyloid plaques in activated microglia and astrocytes in the Tg2576 transgenic mice having mutant amyloid precursor protein (APP) [71].
P2X7 receptor Binding (associated) of in microglia associated with targeted disruption, alzheimer's dementia and amyloid plaque
19) Confidence 0.04 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096753 Disease Relevance 1.07 Pain Relevance 0.07

General Comments

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