INT144829

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Context Info
Confidence 0.79
First Reported 2007
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 2.92
Pain Relevance 2.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx7) cell morphogenesis (P2rx7) mitochondrion organization (P2rx7)
protein complex (P2rx7) transmembrane transport (P2rx7) cytoplasm (P2rx7)
Anatomy Link Frequency
pore 2
macrophage 1
C8-B4 1
brain 1
neutrophils 1
P2rx7 (Mus musculus)
Pain Link Frequency Relevance Heat
neurotransmitter 1 99.36 Very High Very High Very High
inflammatory 249 98.28 Very High Very High Very High
Glutamate 2 97.76 Very High Very High Very High
GABA 2 97.20 Very High Very High Very High
cytokine 198 96.96 Very High Very High Very High
pain 19 96.80 Very High Very High Very High
multiple sclerosis 8 96.00 Very High Very High Very High
Arthritis 9 94.76 High High
Inflammatory stimuli 16 91.88 High High
central nervous system 4 89.48 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 23 100.00 Very High Very High Very High
INFLAMMATION 300 98.28 Very High Very High Very High
Pain 19 96.80 Very High Very High Very High
Hepatitis 2 96.44 Very High Very High Very High
Demyelinating Disease 8 96.00 Very High Very High Very High
Arthritis 12 94.76 High High
Neuropathic Pain 32 80.64 Quite High
Stroke 6 74.00 Quite High
Brain Injury 10 73.36 Quite High
Disease 50 72.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, P2X7R-stimulated release of traditional neurotransmitters in the brain, such as glutamate and GABA, further supports the involvement of P2X7R in neuro-inflammatory and -degenerative processes.
Localization (release) of P2X7R in brain associated with gaba, glutamate, neurotransmitter and inflammatory
1) Confidence 0.79 Published 2007 Journal Curr. Med. Chem. Section Abstract Doc Link 17584060 Disease Relevance 0.44 Pain Relevance 0.51
secretion, the P2X7R has been implicated in the synthesis and release of the related leaderless cytokine IL-18 (interferon-?
Localization (secretion) of P2X7R associated with cytokine
2) Confidence 0.69 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.67 Pain Relevance 0.35
Evidence for P2X7R ion channel itself as the large pore
Localization (pore) of P2X7R in pore
3) Confidence 0.69 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0.24 Pain Relevance 0.15
Firstly, it is not clear how a P2X7R/panx1 permeabilization pore that is presumably limited to molecules <900 Da can transfer larger PAMPs.
Localization (permeabilization) of P2X7R in pore
4) Confidence 0.69 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0.08 Pain Relevance 0.07
release

The P2X7 receptor (P2X7R) is uniquely associated with two distinct cellular responses: activation of a dye-permeable pathway allowing passage of molecules up to 900 Da and rapid release of the pro-inflammatory cytokine, interleukin-1?

Localization (release) of P2X7R associated with inflammatory and cytokine
5) Confidence 0.65 Published 2009 Journal Purinergic Signal Section Title Doc Link PMC2686830 Disease Relevance 0.09 Pain Relevance 0.09
release

The P2X7 receptor (P2X7R) is uniquely associated with two distinct cellular responses: activation of a dye-permeable pathway allowing passage of molecules up to 900 Da and rapid release of the pro-inflammatory cytokine, interleukin-1?

Localization (release) of P2X7 receptor associated with inflammatory and cytokine
6) Confidence 0.65 Published 2009 Journal Purinergic Signal Section Title Doc Link PMC2686830 Disease Relevance 0.09 Pain Relevance 0.09
Although these changes are different to those observed in P2X7 ????
Localization (observed) of P2X7
7) Confidence 0.64 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.25 Pain Relevance 0.24
Subsequent studies showing that cultured microglia from P2X7R knockout mice do not release IL-1?
Neg (not) Localization (release) of P2X7R in microglia associated with targeted disruption
8) Confidence 0.61 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.81 Pain Relevance 0.27
Circulating human neutrophils express P2Y4 and P2Y6 mRNAs, and the P2X7 receptor is reported to be present in these cells [22].
Localization (reported) of P2X7 receptor in neutrophils
9) Confidence 0.34 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0.07 Pain Relevance 0.13
Panx1 and P2X7R co-immunoprecipitated in HEK 293 cells; small interfering RNA (siRNA) directed against panx1, a panx1-mimetic inhibitory peptide (10panx1 peptide), and CBX all inhibited P2X7R-mediated dye uptake but not membrane currents or calcium flux in HEK 293 cells and in human and murine macrophage [40].
Localization (immunoprecipitated) of P2X7R in macrophage
10) Confidence 0.30 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0
, as well as P2X7R and panx1 [40, 52–55], but a secondary stimulus is required for efficient processing and release of bioactive IL-1?
Localization ([40) of P2X7R
11) Confidence 0.30 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0.18 Pain Relevance 0.13
We found significant amounts of P2X3, P2X4, P2X6, and P2X7 transcripts in resting C8-B4 cells with the following relative expression levels: P2X7 > P2X4 > P2X3 > P2X6.
Spec (analyzed) Localization (amounts) of P2X7 in C8-B4
12) Confidence 0.10 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0.09

General Comments

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