INT144830

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Context Info
Confidence 0.68
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 24
Disease Relevance 9.78
Pain Relevance 3.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx7) cell morphogenesis (P2rx7) mitochondrion organization (P2rx7)
protein complex (P2rx7) transmembrane transport (P2rx7) cytoplasm (P2rx7)
Anatomy Link Frequency
microglial cells 7
macrophages 6
pore 4
astrocytes 3
monocytes 2
P2rx7 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 168 99.92 Very High Very High Very High
Central nervous system 12 99.86 Very High Very High Very High
Inflammation 704 99.56 Very High Very High Very High
antagonist 205 96.80 Very High Very High Very High
cytokine 662 96.60 Very High Very High Very High
rheumatoid arthritis 79 91.20 High High
Arthritis 33 90.28 High High
Inflammatory response 81 90.16 High High
Neurotransmitter 6 86.08 High High
Glutamate 6 82.88 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 870 99.56 Very High Very High Very High
Amyloid Plaque 11 99.20 Very High Very High Very High
Alzheimer's Dementia 16 97.12 Very High Very High Very High
Targeted Disruption 89 96.04 Very High Very High Very High
Apoptosis 291 95.96 Very High Very High Very High
Hypertension 5 95.96 Very High Very High Very High
Disease 247 95.36 Very High Very High Very High
Autoimmune Disease 17 94.84 High High
Rheumatoid Arthritis 79 91.20 High High
Syndrome 11 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It appears that microglia, the principal immune cells of the central nervous system, have enhanced P2X7R expression following inflammatory insults (see above) [3,75].
Positive_regulation (enhanced) of Gene_expression (expression) of P2X7R in central nervous system associated with inflammation and central nervous system
1) Confidence 0.68 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.51 Pain Relevance 0.30
Since the P2X7R is important in the production of both TNF-?
Positive_regulation (Since) of Gene_expression (important) of P2X7R
2) Confidence 0.49 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.96 Pain Relevance 0.44
Indeed, in an elegant series of studies Surprenant and colleagues have subsequently demonstrated that ATP-induced activation of the P2X7R results in the shedding of microvesicles which contain mature IL-1?
Positive_regulation (activation) of Gene_expression (results) of P2X7R
3) Confidence 0.49 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.51 Pain Relevance 0.10
These authors showed that the P2X7R is up-stream of the inflammasome, an important complex of cytosolic proteins that are known to regulate caspase-1 activation and ultimately the processing of IL-1?
Positive_regulation (activation) of Gene_expression (processing) of P2X7R
4) Confidence 0.49 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.67 Pain Relevance 0.34
It also raises the interesting possibility that P2X7 may act directly upon IL-10, as seen with IL-1?
Positive_regulation (upon) of Gene_expression (act) of P2X7
5) Confidence 0.49 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.21 Pain Relevance 0.21
Evidence for P2X7R ion channel itself as the large pore
Positive_regulation (for) of Gene_expression (itself) of P2X7R in pore
6) Confidence 0.46 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0.23 Pain Relevance 0.15
Evidence for P2X7R ion channel itself as the large pore
Positive_regulation (for) of Gene_expression (Evidence) of P2X7R in pore
7) Confidence 0.46 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0.23 Pain Relevance 0.15
as well as enhances the expression and activity of P2X7R and panx1.
Positive_regulation (enhances) of Gene_expression (expression) of P2X7R
8) Confidence 0.46 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0.05 Pain Relevance 0
Upon stimulation by high concentrations of ATP it generates a non-selective membrane pore which is permeable to hydrophilic molecules with molecular weight up to 900 Da. ii) Though its physiological function is yet to be fully understood, there is high P2X7R expression in microglia.
Positive_regulation (high) of Gene_expression (expression) of P2X7R in microglia
9) Confidence 0.46 Published 2007 Journal Curr. Med. Chem. Section Abstract Doc Link 17584060 Disease Relevance 0.38 Pain Relevance 0.41
The significance of P2X7R regulation of superoxides was underlined by the observation that P2X7R expression was up-regulated around ?
Positive_regulation (up-regulated) of Gene_expression (expression) of P2X7R
10) Confidence 0.46 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 1.42 Pain Relevance 0.20
More importantly, as activation of these cell types is associated with increased expression of the P2X7R, this ultimately leads to an amplification of the downstream production of the pro-inflammatory cytokines IL-1?
Positive_regulation (increased) of Gene_expression (expression) of P2X7R associated with inflammation and cytokine
11) Confidence 0.46 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.60 Pain Relevance 0.46
Bulanova et al. [25] have shown that addition of extracellular ATP in the millimolar range induced activation of P2X7 expressed on murine mast cells, resulting in the rapid but transient phosphorylation of ERK, Jak2 and STAT6.
Positive_regulation (activation) of Gene_expression (expressed) of P2X7 in mast cells
12) Confidence 0.46 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.44 Pain Relevance 0.13
In contrast, the IL-6 response was enhanced in P2X7 ????
Positive_regulation (enhanced) of Gene_expression (???) of P2X7
13) Confidence 0.43 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.08 Pain Relevance 0.28
However, the maximum mean score observed in P2X7 ????
Positive_regulation (observed) of Gene_expression (observed) of P2X7
14) Confidence 0.43 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.34 Pain Relevance 0.13
P2X7 receptor overexpression is also associated with microglial cells in other pathological models; e.g., P2X7 receptor immunoreactivity appears to be upregulated around amyloid plaques in activated microglia and astrocytes in the Tg2576 transgenic mice having mutant amyloid precursor protein (APP) [71].
Positive_regulation (overexpression) of Gene_expression (overexpression) of P2X7 receptor in astrocytes associated with targeted disruption, alzheimer's dementia and amyloid plaque
15) Confidence 0.25 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096753 Disease Relevance 1.07 Pain Relevance 0.07
Similarly, K+ efflux mediated via P2X7 receptor activation in LPS-stimulated monocytes and macrophages is necessary for efficient IL-1?
Positive_regulation (via) of Gene_expression (activation) of P2X7 receptor in macrophages
16) Confidence 0.23 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0
Similarly, K+ efflux mediated via P2X7 receptor activation in LPS-stimulated monocytes and macrophages is necessary for efficient IL-1?
Positive_regulation (mediated) of Gene_expression (activation) of P2X7 receptor in macrophages
17) Confidence 0.23 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0
Analysis of peritoneal macrophages obtained from mice genetically engineered to lack the P2X7 receptor provided the final piece of evidence that P2X7 receptor function is necessary for ATP-induced IL-1?
Positive_regulation (necessary) of Gene_expression (function) of P2X7 receptor in peritoneal macrophages
18) Confidence 0.23 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0.09
Altogether, these data indicate that the expression of P2X7 receptors is strongly activity-dependent during pathological situations.
Positive_regulation (dependent) of Gene_expression (expression) of P2X7
19) Confidence 0.18 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096753 Disease Relevance 0.89 Pain Relevance 0.06
Interestingly, ADP and AMP also act as agonists of P2X7 receptors in microglial cells in terms of membrane currents and LPS induced IL–?
Positive_regulation (induced) of Gene_expression (receptors) of P2X7 in microglial cells associated with agonist
20) Confidence 0.18 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096753 Disease Relevance 0.05 Pain Relevance 0.20

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